Gastroprotective Effect of Hydro-Alcoholic Extract of Polygonum bistorta Lin Root in Indomethacin- Induced Gastric Ulcers in Sprague Dawley Rats

2018 ◽  
Vol 52 (4) ◽  
pp. 618-625
Author(s):  
Mohammad Khushtar ◽  
Aijaz Ahmad ◽  
Md. Azizur Rahman
Keyword(s):  
Gastric Ulcers ◽  
Alcoholic Extract ◽  
Sprague Dawley ◽  
Gastroprotective Effect ◽  
Sprague Dawley Rats

scholarly journals The Protective Effect of Testosterone on Indomethacin Induced Gastric Ulcer in Female Sprague Dawley Rats

2016 ◽  
Vol 2016 ◽  
pp. 1-5
Author(s):  
U. Akpamu ◽  
H. O. Otamere ◽  
I. O. Ernest-Nwoke ◽  
C. N. Ekhator ◽  
U. C. Osifo
Keyword(s):  
Gastric Ulcer ◽  
Female Rats ◽  
Gastric Ulcers ◽  
Standard Laboratory ◽  
Sprague Dawley ◽  
Gastric Mucus ◽  
Ulcer Index ◽  
Sprague Dawley Rats ◽  
Group A ◽  
Group B

Gastric ulcer has shown association with changes in sex hormones, with impact exacerbated in males. Also, males are known to be more exposed to ulcer risk factors. This study investigates the effect of testosterone on indomethacin induced gastric ulcers in adult female rats. Eighteen female rats (225 ± 25 g body weight) were randomly assigned to 3 groups under standard laboratory condition. After acclimatization, animals fasted for 40 hrs but were given water ad libitum. Group A served as control while group B served as the ulcer control, in which ulcer was induced without treatment using indomethacin (40 mg/kg single orally dose). Group C was pretreated with testosterone (1 mg/kg IM) eight hours before ulcer induction. Eight hours after ulcer induction, animals were sacrificed and the stomach was harvested for analysis. Results showed a significant reduction in mucus content in groups C (0.79±0.11 g) and B (0.87±0.02 g) compared to A (1.11±0.03 g). Gastric mucus pH was significantly acidic in group B (4.40±0.55) compared to C (5.20±0.45) and A (5.80±0.45). There was a significantly higher ulcer index in group B (4.60±0.55 mm) compared to C (3.60±0.89 mm) and testosterone pretreatment resulted in a 21.74% ulcer inhibition. Although weak, the findings suggest that testosterone might protect the gastric mucosa against NSAIDs in females.

scholarly journals Anxiolytic Effects of Acanthopanax senticosus HARMS Occur via Regulation of Autonomic Function and Activate Hippocampal BDNF–TrkB Signaling

Molecules ◽  
2018 ◽  
Vol 24 (1) ◽  
pp. 132 ◽  
Author(s):  
Shouhei Miyazaki ◽  
Hirotaka Oikawa ◽  
Hideo Takekoshi ◽  
Masako Hoshizaki ◽  
Masato Ogata ◽  
...  
Keyword(s):  
Autonomic Function ◽  
Nervous Activity ◽  
Anxiolytic Effect ◽  
Gastric Ulcers ◽  
Sympathetic Nervous Activity ◽  
Sprague Dawley ◽  
Bdnf Expression ◽  
Acanthopanax Senticosus ◽  
Sprague Dawley Rats ◽  
Bdnf Signaling

Mental stress, such as anxiety and conflict, causes physiological changes, such as changes in autonomic nervous activity and gastric ulcers. In addition, stress induces glucocorticoids and changes the hippocampal brain-derived neurotrophic factor (BDNF) expression levels. We previously reported that Acanthopanax senticosus HARM (ASH) prevents stress-induced gastric ulcers. Thus, we investigated the potential anxiolytic effect and influence of ASH on the hippocampus BDNF-related protein in male Sprague-Dawley rats fed 1% and 5% ASH extract-containing food for one week using novelty suppressed feeding (NSF) and improved elevated beam walking (IEBW) tests. ASH treatment significantly decreased latency to eat in the NSF test and increased the time spent on the open arm in the IEBW test. ASH5% treatment showed a significant decrease in LFnu, indicative of sympathetic nervous activity, and a significant increase in HFnu, indicative of parasympathetic nervous activity, in the NSF test. In addition, ASH1% and ASH5% treatments significantly decreased LFnu and significantly increased HFnu in the IEBW test. ASH5% treatment significantly increased hippocampal BDNF protein expression in both Western blotting and immunohistochemistry experiments. Our findings suggest that anxiolytic effects of ASH occur via the regulation of autonomic function and increased hippocampal BDNF signaling.

scholarly journals The Gastroprotective Effect of Vitex pubescens Leaf Extract against Ethanol-Provoked Gastric Mucosal Damage in Sprague-Dawley Rats

PLoS ONE ◽  
2016 ◽  
Vol 11 (9) ◽  
pp. e0157431 ◽  
Author(s):  
Nahla Saeed AL-Wajeeh ◽  
Mohammed Farouq Halabi ◽  
Maryam Hajrezaie ◽  
Summaya M. Dhiyaaldeen ◽  
Daleya Abdulaziz Bardi ◽  
...  
Keyword(s):  
Leaf Extract ◽  
Mucosal Damage ◽  
Gastric Mucosal Damage ◽  
Sprague Dawley ◽  
Gastroprotective Effect ◽  
Sprague Dawley Rats

scholarly journals Correction: The Gastroprotective Effect of Vitex pubescens Leaf Extract against Ethanol-Provoked Gastric Mucosal Damage in Sprague-Dawley Rats

PLoS ONE ◽  
2017 ◽  
Vol 12 (5) ◽  
pp. e0179072
Author(s):  
Nahla Saeed AL-Wajeeh ◽  
Mohammed Farouq Halabi ◽  
Maryam Hajrezaie ◽  
Summaya M. Dhiyaaldeen ◽  
Daleya Abdulaziz Bardi ◽  
...  
Keyword(s):  
Leaf Extract ◽  
Mucosal Damage ◽  
Gastric Mucosal Damage ◽  
Sprague Dawley ◽  
Gastroprotective Effect ◽  
Sprague Dawley Rats

scholarly journals Ethanolic extract of okra has a potential gastroprotective effect on acute gastric lesions in Sprague Dawley rats

2020 ◽  
Vol 8 (12) ◽  
pp. 6691-6698 ◽  
Author(s):  
Hafsa Yasin ◽  
Farwa Tariq ◽  
Aysha Sameen ◽  
Nazir Ahmad ◽  
Muhammad Faisal Manzoor ◽  
...  
Keyword(s):  
Ethanolic Extract ◽  
Gastric Lesions ◽  
Sprague Dawley ◽  
Gastroprotective Effect ◽  
Sprague Dawley Rats

scholarly journals Alcoholic Extract of Wrightia tinctoria leaves and Isolates there of afford DNA Protection in Post Irradiated Sprague Dawley Rats

2016 ◽  
Vol 8 (4) ◽  
pp. 398-405
Author(s):  
Sathianarayanan SN ◽  
Asha Jose ◽  
Ranganathan Balasubramanian ◽  
Diana Thomas ◽  
Ashitha Balakrishnan ◽  
...  
Keyword(s):  
Alcoholic Extract ◽  
Sprague Dawley ◽  
Dna Protection ◽  
Sprague Dawley Rats ◽  
Wrightia Tinctoria

The Effect of Age and Strain Differences on the Incidence of Restraint-Induced Oral and Gastric Ulcers in Three Strains of Rats

1972 ◽  
Vol 51 (2) ◽  
pp. 619-625 ◽  
Author(s):  
D.K. Whittaker ◽  
T.R. Wilson
Keyword(s):  
Wistar Rats ◽  
Strain Differences ◽  
Gastric Ulcers ◽  
Sprague Dawley ◽  
Oral Ulcers ◽  
Sprague Dawley Rats ◽  
Different Strains ◽  
Strain Dependent ◽  
Effect Of Age

Restraint of different strains of rat has been shown to be capable of inducing both oral and gastric ulcers. Hooded Wistar rats were most susceptible to gastric ulcers, whereas Sprague-Dawley rats had the highest incidence of oral ulcers. The causative mechanisms probably differ and are strain dependent.

scholarly journals Evaluation of Hepato-protective and Nephron-Protective Potential of Euphorbia nivulia Buch.-Ham. Against Carbon Tetrachloride-induced Toxicity in Sprague Dawley Rats

2021 ◽  
pp. 83-100
Author(s):  
Muhammad Younus ◽  
Muhammad Mohtasheemul Hasan ◽  
Khalil Ahmad ◽  
Ihsanul Haq ◽  
Rizwan Ahmad ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Low Dose ◽  
Positive Control ◽  
High Dose ◽  
Alcoholic Extract ◽  
Sprague Dawley ◽  
Pathological Study ◽  
Hepatic Cells ◽  
Sprague Dawley Rats ◽  
Dose Dependent

Background: Euphorbia nivulia Buch.-Ham (En) is one of the members of Euphorbiaceae family that is rich in phytochemicals including flavonoids, triterpenes and polyphenolics. Purpose: To evaluate hepato-nephronprotective potential of Euphorbia nivulia. Study Design: Sprague Dawley rats were used as animal models in the study. Methods: En hydro alcoholic extract was standardized and managed in high dose (300 mgkg−1 body weight (BW) and low dose  (150 mgkg−1 BW) to Sprague Dawley rats, administered with CCl4 (1mlkg−1BW). Silymarin (50 mgkg−1 BW) was taken as positive control. The treatments were given thrice a week. Consequently, blood and hepatic homogenates were collected after 4 weeks of treatment. While the situation of kidney was explored through measurement of serum creatinine, serum urea, sodium and albumin levels. Hepatic and renal samples of rats treated with both 150 and 300 mg/kg of the extract were used for tissue pathological study. Results: En extract revealed dose dependent moderate level of shelter against CCl4 intoxicated hepato-nephrotoxicity as directed from the acquired results. The decrease of the albumin levels by the maximum dose of the extract exceeded similar to that attained with Silymarin, and the protecting effects of the extract against oxidative destruction were evaluated. Examination of serum show significant (p < 0.05) elevation in the level of aspartate transaminase(AST), alkaline phosphatase(ALP), alanine transaminase(ALT), whereas decline were noted for albumin in CCl4 treated rats. Histopathological cuts and damages were seen in hepatic cells and kidney of rats managed by CCl4. But, co-administration of En extract, dose dependently, improved the CCl4-carried hepatic harms in these limits. Conclusion: These effects propose that the phyto-ingredients of En extract with known polyphenols were able to improve the oxidative stress brought along with CCl4 and may be a useful healing mediator to manage oxidative stress related disorders like hepato-nephro toxicity.

scholarly journals Toxicological evaluation of chronic oral administration of Melissa officinalis hydro-ethanol extract in Sprague-Dawley rats

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Mohammad Hashemnia ◽  
Farid Rezaei ◽  
Zahra Nikousefat ◽  
Maral Bahiraei
Keyword(s):  
Mononuclear Cells ◽  
Control Group ◽  
High Dose ◽  
Alcoholic Extract ◽  
Sprague Dawley ◽  
Melissa Officinalis ◽  
Medicinal Uses ◽  
Sprague Dawley Rats ◽  
Term Administration

Melissa officinalis is a plant that has been widely used as an herbal medicine in many countries. Unfortunately, despite the prevalent medicinal uses of the plant, there are no reports on the possible toxic effects of M. officinalis. This study was designed to evaluate the effect of long-term administration of hydro-alcoholic extract of M. officinalis on some biochemical and hematological parameters and histopathology of organs. Thirty Sprague-Dawley rats were allocated to three equal groups. The animals in groups A and B received 600 and 1200 mg/kg M. officinalis extract, respectively, for 30 days. The rats in group C were given gavaged saline as control. The animals were euthanized at the end of experiment and the blood samples were collected for biochemical and hematology analysis. Additionally, appropriate tissue samples were collected from kidney, liver, spleen, heart and lung for light microscopic examination. M. officinalis caused a significant increase in the alanine aminotransferase level in the treated rats. Although the increase in creatine phosphokinase and lactate dehydrogenase levels were observed in group A and B, respectively, but there were no significant differences. A significant decrease was observed in the total protein and albumin concentrations in serum of treated rats as compared to the control group. The creatinine concentrations were significantly higher in the group B when compared to the other groups. There were no significant differences in cholesterol, triglyceride and urea concentrations between all groups of rats. The main histopathologic findings in the liver were included hepatocyte degeneration, congestion and dilation of sinusoids, proliferation of bile ducts and infiltration of mononuclear cells around the portal area. Histopathologic examination of the kidneys showed a tubular degeneration and necrosis, tubular and glomerular atrophy and congestion. These lesions were more prominent in the high dose treated rats. The findings suggest that long-term administration of M. officinalis extract even at low doses induces hepatic and renal lesions in rats.

Sign in / Sign up

Export Citation Format

Share Document