scholarly journals Ethanolic extract of okra has a potential gastroprotective effect on acute gastric lesions in Sprague Dawley rats

2020 ◽  
Vol 8 (12) ◽  
pp. 6691-6698 ◽  
Author(s):  
Hafsa Yasin ◽  
Farwa Tariq ◽  
Aysha Sameen ◽  
Nazir Ahmad ◽  
Muhammad Faisal Manzoor ◽  
...  
Keyword(s):  
Ethanolic Extract ◽  
Gastric Lesions ◽  
Sprague Dawley ◽  
Gastroprotective Effect ◽  
Sprague Dawley Rats

scholarly journals Ethanolic Extract of Herb Pugun Tanoh (Picria fel-terrae Lour.) Modulates TCD4+ and TCD8+ Cell Profile of Doxorubicin-Induced Immuno-Suppressed Rats

2019 ◽  
Vol 7 (22) ◽  
pp. 3774-3776
Author(s):  
Mustafa Ridwan Lubis ◽  
Reny Haryani ◽  
Safriana Safriana ◽  
Denny Satria
Keyword(s):  
Ethanolic Extract ◽  
Immune Functions ◽  
Sprague Dawley ◽  
Immunomodulatory Effects ◽  
Once Daily ◽  
Sprague Dawley Rats ◽  
Group 3 ◽  
Group 2 ◽  
Cell Profile ◽  
Group 1

AIM: To evaluate the immunomodulatory effects of ethanolic extract of herb pugun tanoh on TCD4 and TCD8 cells in Doxorubicin-induced rats. METHODS: Fifteen male Sprague Dawley rats were divided into five groups consisting of six rats each as follows: Group 1, DOX-treated rats (4.67 mg/kg BW body weight on day 1 and 4) and were administered normal saline 0.9% orally once daily for 7 consecutive days, Group 2, receiving Ethanolic Extract of Herb Pugun Tanoh (Picria fel-terrae Lour.) of dose 150 mg/kg BW orally, Group 3, receiving dose Ethanolic Extract of Herb Pugun Tanoh (Picria fel-terrae Lour.) 300 mg/kg BW orally. The rats of group 2-3 were intramuscularly administered with doxorubicin at a dose of 4.67 mg/kg BW at the days 1-4 to suppress immune functions. RESULTS: Treatment of 300 mg/kg BW of Ethanolic Extract of Herb Pugun Tanoh (Picria fel-terrae Lour.) succeeded in reducing side effect doxorubicin based on increasing the TCD4+ and TCD8+ blood level. CONCLUSION: Ethanolic Extract of Herb Pugun Tanoh (Picria fel-terrae Lour.) could increase the level of TCD4+ and TCD8+ in rats which induced by doxorubicin.

scholarly journals Genotoxicity, acute and subchronic toxicity studies of nano liposomes of Orthosiphon stamineus ethanolic extract in Sprague Dawley rats

2015 ◽  
Vol 15 (1) ◽  
Author(s):  
Armaghan Shafaei ◽  
Kameh Esmailli ◽  
Elham Farsi ◽  
Abdalrahim F. A. Aisha ◽  
Amin Malik Shah Abul Majid ◽  
...  
Keyword(s):  
Ethanolic Extract ◽  
Sprague Dawley ◽  
Subchronic Toxicity ◽  
Orthosiphon Stamineus ◽  
Toxicity Studies ◽  
Sprague Dawley Rats

Hepatoprotective activity of Tamarindus indica Linn stem bark ethanolic extract against hepatic damage induced by co-administration of antitubercular drugs isoniazid and rifampicin in Sprague Dawley rats

2018 ◽  
Vol 30 (1) ◽  
pp. 131-137 ◽  
Author(s):  
Shaikh Zohra Meena ◽  
Md. Azizur Rahman ◽  
Paramdeep Bagga ◽  
Md. Mujahid
Keyword(s):  
Ethanolic Extract ◽  
Stem Bark ◽  
Hepatoprotective Activity ◽  
Group Iv ◽  
Hepatic Damage ◽  
Sprague Dawley ◽  
Group V ◽  
Group Iii ◽  
Group I ◽  
Sprague Dawley Rats

Abstract Background Development of drug-induced hepatic damage (DIHD) during chemotherapy is the most common reason for interruption in chemotherapy. This study evaluated the hepatoprotective activity of the ethanolic extract of Tamarindus indica stem bark (EETI) against the induced DIHD in Sprague Dawley rats. Methods The rats were divided into five groups (n=5). Group I, group III, group IV, and group V rats received 1 mL 1% carboxymethyl cellulose, EETI 100 mg/kg body weight (b.wt), EETI 200 mg/kg b.wt, and silymarin 100 mg/kg b.wt, respectively, orally once every day for 28 days. After 1 h–group II, group III, group IV, and group V rats were administered with isoniazid (INH) and rifampicin (RIF) 50 mg/kg b.wt each orally once every day for 28 days. Then, 24 h after the last dosing, blood was withdrawn from the rats and analyzed for liver specific enzymes and biochemical markers. They were examined for histopathology. Results Co-administration of INH and RIF in group II significantly increased alanine transaminase, aspartate transaminase, alkaline phosphatase, lactate dehydrogenase, serum bilirubin, and cholesterol levels while reduced the total protein and albumin levels compared to that of group I. EETI in group III and group IV rats significantly restored the liver specific enzymes and biochemical markers altered due to co-administration of INH and RIF to normal in a dose-dependent manner. EETI 200 mg/kg b.wt showed better protection to liver than EETI 100 mg/kg b.wt and was comparable to silymarin 100 mg/kg b.wt. It was well supported with histopathology of liver tissues. Conclusions EETI possesses hepatoprotective activity against DIHD in rats. It may have a substantial impact on developing clinical strategies to treat patients with hepatic damage.

scholarly journals The Gastroprotective Effect of Vitex pubescens Leaf Extract against Ethanol-Provoked Gastric Mucosal Damage in Sprague-Dawley Rats

PLoS ONE ◽  
2016 ◽  
Vol 11 (9) ◽  
pp. e0157431 ◽  
Author(s):  
Nahla Saeed AL-Wajeeh ◽  
Mohammed Farouq Halabi ◽  
Maryam Hajrezaie ◽  
Summaya M. Dhiyaaldeen ◽  
Daleya Abdulaziz Bardi ◽  
...  
Keyword(s):  
Leaf Extract ◽  
Mucosal Damage ◽  
Gastric Mucosal Damage ◽  
Sprague Dawley ◽  
Gastroprotective Effect ◽  
Sprague Dawley Rats
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