Analysis of Brazilian Plant Extracts as Potential Source of Antioxidant Natural Products Using Bench-Top Assays

2018 ◽  
Vol 8 (2) ◽  
pp. 120-129
Author(s):  
Lucyana C Marin ◽  
Ellen C.M Cavarsan ◽  
Ingrit E.C Diaz ◽  
Mateus L.B Paciencia ◽  
Sergio A Frana ◽  
...  
Keyword(s):  
Natural Products ◽  
Plant Extracts ◽  
Potential Source

scholarly journals Antiviral Natural Products for Arbovirus Infections

Molecules ◽  
2020 ◽  
Vol 25 (12) ◽  
pp. 2796 ◽  
Author(s):  
Vanessa Shi Li Goh ◽  
Chee-Keng Mok ◽  
Justin Jang Hann Chu
Keyword(s):  
Natural Products ◽  
Side Effects ◽  
Plant Extracts ◽  
Antiviral Drug ◽  
Good Tolerability ◽  
Antiviral Compounds ◽  
Potential Source ◽  
Herbal Plants ◽  
Antiviral Activities ◽  
Arboviral Diseases

Over the course of the last 50 years, the emergence of several arboviruses have resulted in countless outbreaks globally. With a high proportion of infections occurring in tropical and subtropical regions where arthropods tend to be abundant, Asia in particular is a region that is heavily affected by arboviral diseases caused by dengue, Japanese encephalitis, West Nile, Zika, and chikungunya viruses. Major gaps in protection against the most significant emerging arboviruses remains as there are currently no antivirals available, and vaccines are only available for some. A potential source of antiviral compounds could be discovered in natural products—such as vegetables, fruits, flowers, herbal plants, marine organisms and microorganisms—from which various compounds have been documented to exhibit antiviral activities and are expected to have good tolerability and minimal side effects. Polyphenols and plant extracts have been extensively studied for their antiviral properties against arboviruses and have demonstrated promising results. With an abundance of natural products to screen for new antiviral compounds, it is highly optimistic that natural products will continue to play an important role in contributing to antiviral drug development and in reducing the global infection burden of arboviruses.

scholarly journals Plant-Based Natural Products and Extracts: Potential Source to Develop New Antiviral Drug Candidates

Molecules ◽  
2021 ◽  
Vol 26 (20) ◽  
pp. 6197
Author(s):  
Eyana Thomas ◽  
Laura E. Stewart ◽  
Brien A. Darley ◽  
Ashley M. Pham ◽  
Isabella Esteban ◽  
...  
Keyword(s):  
Natural Products ◽  
Drug Development ◽  
Plant Extracts ◽  
Viral Infections ◽  
Antiviral Drug ◽  
Structural Diversity ◽  
Traditional Use ◽  
Mortality And Morbidity ◽  
Potential Source ◽  
Pharmaceutical Industries

Viral infections are among the most complex medical problems and have been a major threat to the economy and global health. Several epidemics and pandemics have occurred due to viruses, which has led to a significant increase in mortality and morbidity rates. Natural products have always been an inspiration and source for new drug development because of their various uses. Among all-natural sources, plant sources are the most dominant for the discovery of new therapeutic agents due to their chemical and structural diversity. Despite the traditional use and potential source for drug development, natural products have gained little attention from large pharmaceutical industries. Several plant extracts and isolated compounds have been extensively studied and explored for antiviral properties against different strains of viruses. In this review, we have compiled antiviral plant extracts and natural products isolated from plants reported since 2015.

scholarly journals Metabolomic-Guided Isolation of Bioactive Natural Products from Curvularia sp., an Endophytic Fungus of Terminalia laxiflora

Planta Medica ◽  
2017 ◽  
Vol 84 (03) ◽  
pp. 182-190 ◽  
Author(s):  
Ahmed Tawfike ◽  
Grainne Abbott ◽  
Louise Young ◽  
RuAngelie Edrada-Ebel
Keyword(s):  
Natural Products ◽  
Leukemia Cell ◽  
Myelogenous Leukemia ◽  
Leukemia Cell Line ◽  
Ionization Mass ◽  
Bioactive Components ◽  
Bioactive Natural Products ◽  
Linear Peptide ◽  
Potential Source ◽  
Fungal Extracts

AbstractEndophytic fungi associated with medicinal plants are a potential source of novel chemistry and biology. Metabolomic tools were successfully employed to compare the metabolite fingerprints of solid and liquid culture extracts of endophyte Curvularia sp. isolated from the leaves of Terminalia laxiflora. Natural product databases were used to dereplicate metabolites in order to determine known compounds and the presence of new natural products. Multivariate analysis highlighted the putative metabolites responsible for the bioactivity of the fungal extract and its fractions on NF-κB and the myelogenous leukemia cell line K562. Metabolomic tools and dereplication studies using high-resolution electrospray ionization mass spectrometry directed the fractionation and isolation of the bioactive components from the fungal extracts. This resulted in the isolation of N-acetylphenylalanine (1) and two linear peptide congeners of 1: dipeptide N-acetylphenylalanyl-L-phenylalanine (2) and tripeptide N-acetylphenylalanyl-L-phenylalanyl-L-leucine (3).

scholarly journals Using UHPLC-MS Profiling for the Discovery of New Dihydro-β-Agarofurans from Australian Celastraceae Plant Extracts

Molecules ◽  
2019 ◽  
Vol 24 (5) ◽  
pp. 859 ◽  
Author(s):  
Mario Wibowo ◽  
Paul Forster ◽  
Gordon Guymer ◽  
Andreas Hofmann ◽  
Rohan Davis
Keyword(s):  
Natural Products ◽  
Detailed Analysis ◽  
Plant Extracts ◽  
Analytical Method ◽  
Large Scale ◽  
Endemic Plant ◽  
Plant Materials ◽  
Scientific Databases ◽  
New Compounds ◽  
Mixed Samples

An analytical method using UHPLC-MS was developed and applied to 16 crude CH2Cl2 extracts from Australian Celastraceae plants; the endemic plant materials were accessed from Griffith University’s NatureBank resource and included bark, fruit, leaf, root, twig and mixed samples, all of which were collected from Queensland, Australia. The generated UHPLC-MS data were analysed and dereplicated using the scientific databases Dictionary of Natural Products and SciFinder Scholar in order to potentially identify new dihydro-β-agarofurans from local Celastraceae plants. These investigations led to the large-scale extraction and isolation work on a prioritised fruit sample that belonged to the rainforest plant Denhamia celastroides. Chemical investigations resulted in the purification of four new natural products, denhaminols O–R (1–4), along with the related and known compound, denhaminol G (5). The structures of all the new compounds were determined via detailed analysis of NMR and MS data.

scholarly journals The Effects of Apigenin and Curcumin on Autophagy Related Cell Death and Apoptosis

Proceedings ◽  
2018 ◽  
Vol 2 (25) ◽  
pp. 1586
Author(s):  
Sera Kayacan ◽  
Kaan Yilancioglu ◽  
Ayse Seda Akdemir ◽  
Fatma Kaya Dagistanli ◽  
Gulay Melikoglu ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cell Death ◽  
Natural Products ◽  
Plant Extracts ◽  
Mtt Assay ◽  
Hela Cells ◽  
Qrt Pcr ◽  
Antiviral Effects ◽  
Related Cell ◽  
Promising Therapeutic Approach

: Cervical cancer is one of the frequent types of cancer seen in females. It has been suggested that natural compounds can be used effectively for cancer treatment. Apoptosis and autophagy related cell death play important roles in suppression of tumorigenesis. Apigenin and curcumin are natural products isolated from plant extracts known to have antitumoral, antibacterial and antiviral effects. Varying doses of curcumin and apigenin were applied to HeLa cancer cell lines. The expression of the genes related to apoptosis and/or autophagy related cell death were measured using qRT-PCR and cell viability was measured using MTT assay. Our results showed that curcumin and apigenin are effective on apoptosis and autophagy related cell death in HeLa cells. We suggested that these natural products seem to be a new promising therapeutic approach in cancer.

scholarly journals Macroalgal Endophytes from the Atlantic Coast of Canada: A Potential Source of Antibiotic Natural Products?

2013 ◽  
Vol 1 (1) ◽  
pp. 175-187 ◽  
Author(s):  
Andrew Flewelling ◽  
Katelyn Ellsworth ◽  
Joseph Sanford ◽  
Erica Forward ◽  
John Johnson ◽  
...  
Keyword(s):  
Natural Products ◽  
Atlantic Coast ◽  
Potential Source

scholarly journals Antibiofilm Potential of Medicinal Plants against Candida spp. Oral Biofilms: A Review

Antibiotics ◽  
2021 ◽  
Vol 10 (9) ◽  
pp. 1142
Author(s):  
Rafaela Guimarães ◽  
Catarina Milho ◽  
Ângela Liberal ◽  
Jani Silva ◽  
Carmélia Fonseca ◽  
...  
Keyword(s):  
Natural Products ◽  
Medicinal Plants ◽  
Oral Cavity ◽  
Plant Extracts ◽  
Fungal Infections ◽  
High Capacity ◽  
Biologically Active ◽  
Antibiofilm Activity ◽  
Candida Spp

The use of natural products to promote health is as old as human civilization. In recent years, the perception of natural products derived from plants as abundant sources of biologically active compounds has driven their exploitation towards the search for new chemical products that can lead to further pharmaceutical formulations. Candida fungi, being opportunistic pathogens, increase their virulence by acquiring resistance to conventional antimicrobials, triggering diseases, especially in immunosuppressed hosts. They are also pointed to as the main pathogens responsible for most fungal infections of the oral cavity. This increased resistance to conventional synthetic antimicrobials has driven the search for new molecules present in plant extracts, which have been widely explored as alternative agents in the prevention and treatment of infections. This review aims to provide a critical view and scope of the in vitro antimicrobial and antibiofilm activity of several medicinal plants, revealing species with inhibition/reduction effects on the biofilm formed by Candida spp. in the oral cavity. The most promising plant extracts in fighting oral biofilm, given their high capacity to reduce it to low concentrations were the essential oils extracted from Allium sativum L., Cinnamomum zeylanicum Blume. and Cymbopogon citratus (DC) Stapf.

scholarly journals SCREENING FOR VIETNAMESE PLANT EXTRACTS WITH POTENTIAL BENEFIT FOR ANTI OSTEOCLASTOGENESISH

2021 ◽  
Vol 59 (4) ◽  
pp. 507
Author(s):  
Hai Dang Nguyen ◽  
Thanh Huong Le ◽  
Thu Trang Duong
Keyword(s):  
Side Effects ◽  
Bone Resorption ◽  
Bone Formation ◽  
Plant Extracts ◽  
Potential Benefit ◽  
Mouse Macrophage ◽  
Potential Source ◽  
Inhibitory Activities ◽  
First Time

Bone's homeostasis is only achieved when there is a balance between bone formation and bone resorption. A metabolic disorder of bone-resorbing osteoclasts can lead to osteoporosis. Long-term use of anti-osteoporosis drugs can lead to undesirable side effects so traditional herbal can be a potential source of alternative medicine. In the present study, forty one Vietnamese plants (seventy methanol extracts) were screened for osteoclastogenesis inhibitory activities on RAW264.7 mouse macrophage cells. For the first time, 29 extracts from 24 species showed potential as effective inhibitors of osteoclastogenesis.

scholarly journals Natural Products as Potential Leads Against Coronaviruses: Could They be Encouraging Structural Models Against SARS-CoV-2?

2020 ◽  
Vol 10 (4) ◽  
pp. 171-186 ◽  
Author(s):  
Ilkay Erdogan Orhan ◽  
F. Sezer Senol Deniz
Keyword(s):  
Infectious Disease ◽  
Natural Products ◽  
Medicinal Plants ◽  
Severe Acute Respiratory Syndrome ◽  
Antiviral Activity ◽  
Plant Extracts ◽  
Vaccine Development ◽  
Genomic Sequence ◽  
Structural Models ◽  
Positive Sense

Abstract New coronavirus referred to SARS-CoV-2 has caused a worldwide pandemic (COVID-19) declared by WHO. Coronavirus disease 2019 (COVID-19) is an infectious disease with severe acute respiratory syndrome caused by coronavirus-2 (SARS-CoV-2). SARS-CoV-2 is akin to SARS-CoV, which was the causative agent of severe acute respiratory syndrome (SARS) in 2002 as well as to that of Middle East respiratory syndrome (MERS) in 2012. SARS-CoV-2 has been revealed to belong to Coronaviridiae family as a member of β-coronaviruses. It has a positive-sense single-stranded RNA with the largest RNA genome. Since its genomic sequence has a notable similarity to that of SARS-CoV, antiviral drugs used to treat SARS and MERS are now being also applied for COVID-19 treatment. In order to combat SARS-CoV-2, many drug and vaccine development studies at experimental and clinical levels are currently conducted worldwide. In this sense, medicinal plants and the pure natural molecules isolated from plants have been reported to exhibit significant inhibitory antiviral activity against SARS-CoV and other types of coronaviruses. In the present review, plant extracts and natural molecules with the mentioned activity are discussed in order to give inspiration to researchers to take these molecules into consideration against SARS-CoV-2.

Plant Natural Products as a Potential Source for Antibacterial Agents: Recent Trends

2009 ◽  
Vol 8 (3) ◽  
pp. 211-225 ◽  
Author(s):  
M. Shahid ◽  
A. Shahzad ◽  
F. Sobia ◽  
A. Sahai ◽  
T. Tripathi ◽  
...  
Keyword(s):  
Natural Products ◽  
Antibacterial Agents ◽  
Plant Natural Products ◽  
Potential Source ◽  
Recent Trends
Sign in / Sign up

Export Citation Format

Share Document