scholarly journals Macroalgal Endophytes from the Atlantic Coast of Canada: A Potential Source of Antibiotic Natural Products?

2013 ◽  
Vol 1 (1) ◽  
pp. 175-187 ◽  
Author(s):  
Andrew Flewelling ◽  
Katelyn Ellsworth ◽  
Joseph Sanford ◽  
Erica Forward ◽  
John Johnson ◽  
...  
Keyword(s):  
Natural Products ◽  
Atlantic Coast ◽  
Potential Source

scholarly journals Antiviral Natural Products for Arbovirus Infections

Molecules ◽  
2020 ◽  
Vol 25 (12) ◽  
pp. 2796 ◽  
Author(s):  
Vanessa Shi Li Goh ◽  
Chee-Keng Mok ◽  
Justin Jang Hann Chu
Keyword(s):  
Natural Products ◽  
Side Effects ◽  
Plant Extracts ◽  
Antiviral Drug ◽  
Good Tolerability ◽  
Antiviral Compounds ◽  
Potential Source ◽  
Herbal Plants ◽  
Antiviral Activities ◽  
Arboviral Diseases

Over the course of the last 50 years, the emergence of several arboviruses have resulted in countless outbreaks globally. With a high proportion of infections occurring in tropical and subtropical regions where arthropods tend to be abundant, Asia in particular is a region that is heavily affected by arboviral diseases caused by dengue, Japanese encephalitis, West Nile, Zika, and chikungunya viruses. Major gaps in protection against the most significant emerging arboviruses remains as there are currently no antivirals available, and vaccines are only available for some. A potential source of antiviral compounds could be discovered in natural products—such as vegetables, fruits, flowers, herbal plants, marine organisms and microorganisms—from which various compounds have been documented to exhibit antiviral activities and are expected to have good tolerability and minimal side effects. Polyphenols and plant extracts have been extensively studied for their antiviral properties against arboviruses and have demonstrated promising results. With an abundance of natural products to screen for new antiviral compounds, it is highly optimistic that natural products will continue to play an important role in contributing to antiviral drug development and in reducing the global infection burden of arboviruses.

scholarly journals Metabolomic-Guided Isolation of Bioactive Natural Products from Curvularia sp., an Endophytic Fungus of Terminalia laxiflora

Planta Medica ◽  
2017 ◽  
Vol 84 (03) ◽  
pp. 182-190 ◽  
Author(s):  
Ahmed Tawfike ◽  
Grainne Abbott ◽  
Louise Young ◽  
RuAngelie Edrada-Ebel
Keyword(s):  
Natural Products ◽  
Leukemia Cell ◽  
Myelogenous Leukemia ◽  
Leukemia Cell Line ◽  
Ionization Mass ◽  
Bioactive Components ◽  
Bioactive Natural Products ◽  
Linear Peptide ◽  
Potential Source ◽  
Fungal Extracts

AbstractEndophytic fungi associated with medicinal plants are a potential source of novel chemistry and biology. Metabolomic tools were successfully employed to compare the metabolite fingerprints of solid and liquid culture extracts of endophyte Curvularia sp. isolated from the leaves of Terminalia laxiflora. Natural product databases were used to dereplicate metabolites in order to determine known compounds and the presence of new natural products. Multivariate analysis highlighted the putative metabolites responsible for the bioactivity of the fungal extract and its fractions on NF-κB and the myelogenous leukemia cell line K562. Metabolomic tools and dereplication studies using high-resolution electrospray ionization mass spectrometry directed the fractionation and isolation of the bioactive components from the fungal extracts. This resulted in the isolation of N-acetylphenylalanine (1) and two linear peptide congeners of 1: dipeptide N-acetylphenylalanyl-L-phenylalanine (2) and tripeptide N-acetylphenylalanyl-L-phenylalanyl-L-leucine (3).

Analysis of Brazilian Plant Extracts as Potential Source of Antioxidant Natural Products Using Bench-Top Assays

2018 ◽  
Vol 8 (2) ◽  
pp. 120-129
Author(s):  
Lucyana C Marin ◽  
Ellen C.M Cavarsan ◽  
Ingrit E.C Diaz ◽  
Mateus L.B Paciencia ◽  
Sergio A Frana ◽  
...  
Keyword(s):  
Natural Products ◽  
Plant Extracts ◽  
Potential Source

Plant Natural Products as a Potential Source for Antibacterial Agents: Recent Trends

2009 ◽  
Vol 8 (3) ◽  
pp. 211-225 ◽  
Author(s):  
M. Shahid ◽  
A. Shahzad ◽  
F. Sobia ◽  
A. Sahai ◽  
T. Tripathi ◽  
...  
Keyword(s):  
Natural Products ◽  
Antibacterial Agents ◽  
Plant Natural Products ◽  
Potential Source ◽  
Recent Trends

scholarly journals Antileishmanial Activity of Compounds Isolated from Sassafras albidum

2015 ◽  
Vol 10 (7) ◽  
pp. 1934578X1501000
Author(s):  
Divya Pulivarthi ◽  
Kelly Marie Steinberg ◽  
Lianet Monzote ◽  
Abel Piñón ◽  
William N. Setzer
Keyword(s):  
Natural Products ◽  
Stem Bark ◽  
Antileishmanial Activity ◽  
Bark Extract ◽  
Neglected Tropical Disease ◽  
Mouse Macrophage ◽  
Efficient Treatment ◽  
Sassafras Albidum ◽  
Potential Source ◽  
Stem Bark Extract

Leishmaniasis is a neglected tropical disease caused by Leishmania parasitic protozoa, which currently lacks efficient treatment. Natural products have shown promise as a potential source for antiprotozoal drugs. This work focuses on the antileishmanial potential of Sassafras albidum (Lauraceae) bark extract. The crude bark extract of S. albidum showed excellent antileishmanial activity with an IC50 value less than 12.5 μg/mL against promastigotes of L. amazonensis. The chloroform stem bark extract of S. albidum was subjected to preparative column chromatography. Five compounds were isolated, purified by recrystallization, and identified as sesamin, spinescin, β-sitosterol, hexatriacontanal, and 1-triacontanol. Antileishmanial and cytotoxic screening were performed on these compounds. Sesamin exhibited the best activity against L. amazonensis with an IC50 of 15.8 μg/mL and was not cytotoxic to mouse macrophage cells ( CC50 > 100 μg/mL).

scholarly journals A New Micromonospora Strain with Antibiotic Activity Isolated from the Microbiome of a Mid-Atlantic Deep-Sea Sponge

Marine Drugs ◽  
2021 ◽  
Vol 19 (2) ◽  
pp. 105
Author(s):  
Catherine R. Back ◽  
Henry L. Stennett ◽  
Sam E. Williams ◽  
Luoyi Wang ◽  
Jorge Ojeda Gomez ◽  
...  
Keyword(s):  
Natural Products ◽  
Deep Sea ◽  
Bacterial Communities ◽  
Resource Competition ◽  
Multidrug Resistant ◽  
Antibiotic Activity ◽  
Bioactive Metabolites ◽  
Microbial Life ◽  
Potential Source ◽  
Fermentation Broths

To tackle the growing problem of antibiotic resistance, it is essential to identify new bioactive compounds that are effective against resistant microbes and safe to use. Natural products and their derivatives are, and will continue to be, an important source of these molecules. Sea sponges harbour a diverse microbiome that co-exists with the sponge, and these bacterial communities produce a rich array of bioactive metabolites for protection and resource competition. For these reasons, the sponge microbiota constitutes a potential source of clinically relevant natural products. To date, efforts in bioprospecting for these compounds have focused predominantly on sponge specimens isolated from shallow water, with much still to be learned about samples from the deep sea. Here we report the isolation of a new Micromonospora strain, designated 28ISP2-46T, recovered from the microbiome of a mid-Atlantic deep-sea sponge. Whole-genome sequencing reveals the capacity of this bacterium to produce a diverse array of natural products, including kosinostatin and isoquinocycline B, which exhibit both antibiotic and antitumour properties. Both compounds were isolated from 28ISP2-46T fermentation broths and were found to be effective against a plethora of multidrug-resistant clinical isolates. This study suggests that the marine production of isoquinocyclines may be more widespread than previously supposed and demonstrates the value of targeting the deep-sea sponge microbiome as a source of novel microbial life with exploitable biosynthetic potential.

scholarly journals Plant-Based Natural Products and Extracts: Potential Source to Develop New Antiviral Drug Candidates

Molecules ◽  
2021 ◽  
Vol 26 (20) ◽  
pp. 6197
Author(s):  
Eyana Thomas ◽  
Laura E. Stewart ◽  
Brien A. Darley ◽  
Ashley M. Pham ◽  
Isabella Esteban ◽  
...  
Keyword(s):  
Natural Products ◽  
Drug Development ◽  
Plant Extracts ◽  
Viral Infections ◽  
Antiviral Drug ◽  
Structural Diversity ◽  
Traditional Use ◽  
Mortality And Morbidity ◽  
Potential Source ◽  
Pharmaceutical Industries

Viral infections are among the most complex medical problems and have been a major threat to the economy and global health. Several epidemics and pandemics have occurred due to viruses, which has led to a significant increase in mortality and morbidity rates. Natural products have always been an inspiration and source for new drug development because of their various uses. Among all-natural sources, plant sources are the most dominant for the discovery of new therapeutic agents due to their chemical and structural diversity. Despite the traditional use and potential source for drug development, natural products have gained little attention from large pharmaceutical industries. Several plant extracts and isolated compounds have been extensively studied and explored for antiviral properties against different strains of viruses. In this review, we have compiled antiviral plant extracts and natural products isolated from plants reported since 2015.

Bryophytes – an emerging source for herbal remedies and chemical production

2016 ◽  
Vol 14 (4) ◽  
pp. 314-327 ◽  
Author(s):  
Marko S. Sabovljević ◽  
Aneta D. Sabovljević ◽  
Nur Kusaira K. Ikram ◽  
Anantha Peramuna ◽  
Hansol Bae ◽  
...  
Keyword(s):  
Amino Acids ◽  
Natural Products ◽  
Biological Activities ◽  
Herbal Remedies ◽  
Striated Muscles ◽  
Chemical Analyses ◽  
Chemical Production ◽  
Terrestrial Plants ◽  
Specialized Metabolites ◽  
Potential Source

AbstractBryophytes (including mosses, liverworts and hornworts) are a heterogeneous group of terrestrial plants, which comprise over 24,000 species worldwide. Given the various biological activities reported from bryophytes, they have a huge commercial potential. Due to their minute size and rather small biomass in various ecosystems, bryophytes are a seldom part of ethnomedicine and rarely subject to medicinal and chemical analyses. Still, hundreds of novel natural products have been isolated from bryophytes. Bryophytes have been shown to contain numerous potentially useful natural products, including polysaccharides, lipids, rare amino acids, terpenoids, phenylpropanoids, quinones and many other specialized metabolites. Additionally, different bryophyte extracts and isolated compounds have shown antimicrobial, antiviral, cytotoxic, nematocidal, insecticidal, effects on smooth and non-striated muscles, weight loss, plant growth regulators and allelopathic activities. Bryophytes also cause allergies and contact dermatitis. All these effects highlight bryophytes as potential source for herbal remedies and production of chemicals to be used in various products.

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