scholarly journals Plant-Based Natural Products and Extracts: Potential Source to Develop New Antiviral Drug Candidates

Molecules ◽  
2021 ◽  
Vol 26 (20) ◽  
pp. 6197
Author(s):  
Eyana Thomas ◽  
Laura E. Stewart ◽  
Brien A. Darley ◽  
Ashley M. Pham ◽  
Isabella Esteban ◽  
...  
Keyword(s):  
Natural Products ◽  
Drug Development ◽  
Plant Extracts ◽  
Viral Infections ◽  
Antiviral Drug ◽  
Structural Diversity ◽  
Traditional Use ◽  
Mortality And Morbidity ◽  
Potential Source ◽  
Pharmaceutical Industries

Viral infections are among the most complex medical problems and have been a major threat to the economy and global health. Several epidemics and pandemics have occurred due to viruses, which has led to a significant increase in mortality and morbidity rates. Natural products have always been an inspiration and source for new drug development because of their various uses. Among all-natural sources, plant sources are the most dominant for the discovery of new therapeutic agents due to their chemical and structural diversity. Despite the traditional use and potential source for drug development, natural products have gained little attention from large pharmaceutical industries. Several plant extracts and isolated compounds have been extensively studied and explored for antiviral properties against different strains of viruses. In this review, we have compiled antiviral plant extracts and natural products isolated from plants reported since 2015.

scholarly journals Antiviral Natural Products for Arbovirus Infections

Molecules ◽  
2020 ◽  
Vol 25 (12) ◽  
pp. 2796 ◽  
Author(s):  
Vanessa Shi Li Goh ◽  
Chee-Keng Mok ◽  
Justin Jang Hann Chu
Keyword(s):  
Natural Products ◽  
Side Effects ◽  
Plant Extracts ◽  
Antiviral Drug ◽  
Good Tolerability ◽  
Antiviral Compounds ◽  
Potential Source ◽  
Herbal Plants ◽  
Antiviral Activities ◽  
Arboviral Diseases

Over the course of the last 50 years, the emergence of several arboviruses have resulted in countless outbreaks globally. With a high proportion of infections occurring in tropical and subtropical regions where arthropods tend to be abundant, Asia in particular is a region that is heavily affected by arboviral diseases caused by dengue, Japanese encephalitis, West Nile, Zika, and chikungunya viruses. Major gaps in protection against the most significant emerging arboviruses remains as there are currently no antivirals available, and vaccines are only available for some. A potential source of antiviral compounds could be discovered in natural products—such as vegetables, fruits, flowers, herbal plants, marine organisms and microorganisms—from which various compounds have been documented to exhibit antiviral activities and are expected to have good tolerability and minimal side effects. Polyphenols and plant extracts have been extensively studied for their antiviral properties against arboviruses and have demonstrated promising results. With an abundance of natural products to screen for new antiviral compounds, it is highly optimistic that natural products will continue to play an important role in contributing to antiviral drug development and in reducing the global infection burden of arboviruses.

Analysis of Brazilian Plant Extracts as Potential Source of Antioxidant Natural Products Using Bench-Top Assays

2018 ◽  
Vol 8 (2) ◽  
pp. 120-129
Author(s):  
Lucyana C Marin ◽  
Ellen C.M Cavarsan ◽  
Ingrit E.C Diaz ◽  
Mateus L.B Paciencia ◽  
Sergio A Frana ◽  
...  
Keyword(s):  
Natural Products ◽  
Plant Extracts ◽  
Potential Source

scholarly journals Review : Potensi Aktivitas Anti Virus Dari Produk Alami Lebah Kelulut

2021 ◽  
pp. 144
Author(s):  
Muhammad Alib Batistuta ◽  
Annisa Aulia ◽  
Paula Mariana Kustiawan
Keyword(s):  
Natural Products ◽  
Viral Infections ◽  
Scientific Information ◽  
Antiviral Drug ◽  
Stingless Bee ◽  
Herbal Therapy ◽  
Preventive Effort ◽  
To Come ◽  
Tropical Climates ◽  
Analyze Data

Up to present, many deadly diseases are caused by viral infections. Herbal therapy is a preventive effort made by the community to overcome diseases that come from viruses. Antiviral drug resistance is also the reason people consume herbs from natural ingredients. One of the natural products has the potential to come from kelulut bee products consisting of propolis, pollen, and honey. The kelulut bee or stingless bee is a type of bee that is commonly found in countries with tropical climates such as Indonesia, but there is still little scientific information that examines its potential as an antiviral. This study aims to analyze data on the potential antiviral activity of kelulut bee products through the collection of related articles. The research conducted is a literature review, so the research method is carried out by collecting related articles using search engines such as NCBI, Sciencedirect, and Google Schoolar. Kelulut bee products such as propolis, pollen and honey have potential pharmacological activity as antiviral. This anti-viral activity is due to the presence of compounds such as alkaloids, flavones, apigenin derivatives and other compounds which will be discussed further. Natural products from kelulut bees have potential as an alternative to antiviral therapy. It is also recommended to conduct more in-depth research on the potential of kelulut bee natural products to obtain these therapeutic products.

scholarly journals A Review on the Antimicrobial Activity of Propolis and its Synergy with Other Antimicrobial Compounds

2019 ◽  
Vol 4 (5) ◽  
Keyword(s):  
Antimicrobial Activity ◽  
Natural Products ◽  
Drug Development ◽  
Broad Spectrum ◽  
Potential Application ◽  
Drug Resistant ◽  
Antimicrobial Compounds ◽  
Mortality And Morbidity ◽  
Wide Range ◽  
New Drug Development

The alarming increase in the development of drug resistant microbes and the decrease in the efficacy of numerous antibiotics have led to the rise in patient mortality and morbidity affecting various fields of medicine. To combat this development and or the improvement of drugs are paramount. Natural products have long been utilized in the treatment of diseases showing broad spectrum of activity against a wide range of pathogens. In this study, the potential application of propolis to combat drug resistant microbes is reviewed, highlighting the presence and diversity of bioactive compounds with focus on its antimicrobial activity against a number of drug resistant microbes and its synergistic properties with other antimicrobial compounds. It is hoped that this study would enable researchers to continue to analyse propolis compounds and its interactions with other antimicrobial compounds which ultimately paves the way for new drug development.

scholarly journals Antiviral drug discovery: broad-spectrum drugs from nature

2015 ◽  
Vol 32 (1) ◽  
pp. 29-48 ◽  
Author(s):  
J. P. Martinez ◽  
F. Sasse ◽  
M. Brönstrup ◽  
J. Diez ◽  
A. Meyerhans
Keyword(s):  
Natural Products ◽  
Drug Discovery ◽  
Broad Spectrum ◽  
Viral Infections ◽  
Antiviral Drug ◽  
Marine Organisms ◽  
Antiviral Activities

Exploiting the power of nature to fight viral infections. This review describes the concept of direct- and host-acting natural products with broad-spectrum antiviral activities and provides promising examples derived from plants, fungi, bacteria and marine organisms.

Fungal Bioactive Compounds in Pharmaceutical Research and Development

2019 ◽  
Vol 15 (2) ◽  
pp. 211-231 ◽  
Author(s):  
Sanjai Saxena ◽  
Manmohan Chhibber ◽  
Inder Pal Singh
Keyword(s):  
Natural Products ◽  
Drug Discovery ◽  
Drug Development ◽  
Natural Product ◽  
Bioactive Compounds ◽  
Medicinal Chemistry ◽  
Bioactive Compound ◽  
New Drugs ◽  
Ecological Groups ◽  
Pharmaceutical Industries

Background:Exploration of antibiotics from microorganisms became widespread in the academia and the industry with the serendipitous discovery of Penicillin from Penicillium notatum by Sir Alexander Fleming. This embarked the golden era of antibiotics which lasted for over 60 years. However, the traditional phenotypic screening was replaced with more rational and smarter methods of exploration of bioactive compounds from fungi and microorganisms. Fungi have been responsible for providing a variety of bioactive compounds with diverse activities which have been developed into blockbuster drugs such as Cyclosporine, Caspofungin, Lovastatin and Fingolimod etc. It has been reported that ca. 40% of the 1453 New Chemical Entities (NCE’s) approved by USFDA are natural products, natural product inspired or mimics many of which have their origins from fungi. Hence fungal compounds are playing a very important role in drug discovery and development in the pharmaceutical industry.Methods:We undertook structured searches of bibliographic databases of peer-reviewed research literature which pertained to natural products, medicinal chemistry of natural products and drug discovery from fungi. With the strategic improvement in screening and identification methods, fungi are still a potential resource for novel chemistries. Thus the searches also comprised of bioactive agents from fungi isolated or derived from special ecological groups and lineages. To find different molecules derived or isolated from fungi under clinical studies, clinical trial data from the NIH as well as from pharmaceutical companies were also explored. This comprised of data wherein the pharmaceutical industries have acquired or licensed a fungal bioactive compound for clinical study or a trial.Results:Natural product chemistry and medicinal chemistry continue to play an important role in converting a bioactive compound into therapeutic moieties or pharmacophores for new drug development.Conclusion:Thus one can say fungal bioactive compounds are alive and well for development into new drugs as novel ecological groups of fungi as well as novel chemistries are being uncovered. This review further emphasizes the collaboration of fungal biologists with chemists, pharmacologists and biochemists towards the development of newer drugs for taking them into the drug development pipeline.

Enzymatic dimerization in the biosynthetic pathway of microbial natural products

2021 ◽  
Author(s):  
Jiawang Liu ◽  
Anan Liu ◽  
Youcai Hu
Keyword(s):  
Natural Products ◽  
Biosynthetic Pathway ◽  
Structural Diversity ◽  
Cytochrome P450s ◽  
Microbial Natural Products

Cytochrome P450s, laccases, and intermolecular [4 + 2] cyclases, along with other enzymes were utilized to catalyze varied dimerization of matured natural products so as to create the structural diversity and complexity in microorganisms.

scholarly journals Viruses and Type 1 Diabetes: From Enteroviruses to the Virome

2021 ◽  
Vol 9 (7) ◽  
pp. 1519
Author(s):  
Sonia R. Isaacs ◽  
Dylan B. Foskett ◽  
Anna J. Maxwell ◽  
Emily J. Ward ◽  
Clare L. Faulkner ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Viral Infections ◽  
Antiviral Drug ◽  
Virus Detection ◽  
Detection Methods ◽  
Islet Autoimmunity ◽  
Comprehensive Overview ◽  
Drug Candidates

For over a century, viruses have left a long trail of evidence implicating them as frequent suspects in the development of type 1 diabetes. Through vigorous interrogation of viral infections in individuals with islet autoimmunity and type 1 diabetes using serological and molecular virus detection methods, as well as mechanistic studies of virus-infected human pancreatic β-cells, the prime suspects have been narrowed down to predominantly human enteroviruses. Here, we provide a comprehensive overview of evidence supporting the hypothesised role of enteroviruses in the development of islet autoimmunity and type 1 diabetes. We also discuss concerns over the historical focus and investigation bias toward enteroviruses and summarise current unbiased efforts aimed at characterising the complete population of viruses (the “virome”) contributing early in life to the development of islet autoimmunity and type 1 diabetes. Finally, we review the range of vaccine and antiviral drug candidates currently being evaluated in clinical trials for the prevention and potential treatment of type 1 diabetes.

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