scholarly journals Low-Carb/High-Fat/Fried-Food Diet: The Surprising Effects in Triglycerides, Lipid Profile, and Glycemia in a Patient with a Metabolic Syndrome

2021 ◽  
Vol 3 (2) ◽  
pp. 69-74
Author(s):  
Cristian Baldini ◽  
Keyword(s):  
Metabolic Syndrome ◽  
Lipid Profile ◽  
Blood Lipid ◽  
Poor Quality ◽  
Dietary Guidelines ◽  
Cooking Methods ◽  
High Fat ◽  
Fried Food ◽  
Dietary Guidelines For Americans ◽  
Positive Effect

We continuously underestimate the eating process: food and cooking methods play a pivotal role in our health. According to the Dietary Guidelines for Americans (DGA), more than 117 million American adults have one or more preventable chronic diseases, many of which are related to poor quality eating patterns and physical inactivity. Despite the usual belief about fat in the diet, it has shown that fat has a uniquely positive effect on blood lipid concentrations and cardiovascular risk factors. A low-carb/high-fat/fried-food (LCHFFF) diet has shown to be one of the best natural treatments in lipid profile and glycemia in a patient with metabolic syndrome.

scholarly journals Hippocampal electrophysiological responses and changes in oxidative stress marker and serum lipid profile to pharmacological and non-pharmacological treatments of high-fat-fructose diet induced metabolic syndrome

2019 ◽  
Vol 66 (1) ◽  
pp. 32-37
Author(s):  
D. Micháliková ◽  
B. Tyukos Kaprinay ◽  
M. Sasváriová ◽  
K. Švík ◽  
L. Slovák ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Blood Serum ◽  
Lipid Profile ◽  
Caloric Restriction ◽  
Ldl Cholesterol ◽  
Density Lipoprotein ◽  
Pharmacological Treatments ◽  
High Fat ◽  
Neuronal Transmission ◽  
Positive Effect

Abstract The aim of our study was to evaluate the possibility of influencing the risk factors of metabolic syndrome (MetS) and metabolic cognitive syndrome. As a model of MetS, we used high-fat-fructose diet (HFFD) fed hypertriacylglycerolemic (HTG) rats. Control group included HTG rats fed with HFFD during 8 weeks (HFFD8). Furthermore, we tested the effect of pharmacological and non-pharmacological therapies. Non-pharmacological therapy, which we chose, was a change in diet from HFFD (5 weeks) to standard one (3 weeks) and thus caloric restriction (HFFD5+3). The drug we used was rosmarinic acid (RA; 100mg/kg), which we administered to rats after 5 weeks of HFFD once a day for consecutive 3 weeks with current change in diet to standard one (HFFD5+3+RA) or during lasting last 3 weeks of HFFD (HFFD8+RA). After 8 weeks of experiment, lipid peroxidation markers, lipid profile of blood serum, and neuronal transmission and synaptic plasticity (long-term potentiation [LTP]) in hippocampal sections were evaluated in vitro. We observed a significant effect of dietary change in lipid profile (decreased total cholesterol and low-density lipoprotein cholesterol [LDL-cholesterol] and increased high-density lipoprotein cholesterol [HDL-cholesterol]). The combination of pharmacological and non-pharmacological treatments caused a decrease in total cholesterol, LDL-cholesterol, and lipid peroxidation in blood serum. Change in HFFD to standard diet without treatment resulted in slight improvement in neuronal transmission in the hippocampus and caloric restriction alone also had positive effect on LTP maintenance. Our results suggest that combination of pharmacological and non-pharmacological approaches had better impact on the biochemical parameters of MetS in blood serum, but weak impact on neuronal functions in the hippocampus, where the expected positive effect was achieved only by caloric restriction.

scholarly journals Longitudinal analysis of intervention effects on temptations and stages of change for dietary fat using parallel process latent growth modeling

2016 ◽  
Vol 24 (5) ◽  
pp. 572-585 ◽  
Author(s):  
Leslie Ann D Brick ◽  
Si Yang ◽  
Lisa L Harlow ◽  
Colleen A Redding ◽  
James O Prochaska
Keyword(s):  
Stages Of Change ◽  
Daily Intake ◽  
Rate Of Change ◽  
Dietary Guidelines ◽  
High Fat ◽  
Latent Growth ◽  
Intervention Effects ◽  
Randomized Controlled ◽  
Stage Of Readiness ◽  
Dietary Guidelines For Americans

The Dietary Guidelines for Americans recommend a 20–35 percent daily intake of fat. Resisting the temptation to eat high-fat foods, in conjunction with stage of readiness to avoid these foods, has been shown to influence healthy behavior change. Data ( N = 6516) from three randomized controlled trials were pooled to examine the relationships among direct intervention effects on temptations and stage of change for limiting high-fat foods. Findings demonstrate separate simultaneous growth processes in which baseline level of temptations, but not the rate of change in temptations, was significantly related to the change in readiness to avoid high-fat foods.

scholarly journals Metabolic Effects of the Sweet Protein MNEI as a Sweetener in Drinking Water. A Pilot Study of a High Fat Dietary Regimen in a Rodent Model

Nutrients ◽  
2019 ◽  
Vol 11 (11) ◽  
pp. 2643
Author(s):  
Rosa Cancelliere ◽  
Serena Leone ◽  
Cristina Gatto ◽  
Arianna Mazzoli ◽  
Carmine Ercole ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Lipid Profile ◽  
Western Diet ◽  
Metabolic Effects ◽  
High Fat ◽  
Metabolic Derangement ◽  
Dietary Regimen ◽  
Sweet Proteins ◽  
Sweet Protein ◽  
Typical Western Diet

Sweeteners have become integrating components of the typical western diet, in response to the spreading of sugar-related pathologies (diabetes, obesity and metabolic syndrome) that have stemmed from the adoption of unbalanced dietary habits. Sweet proteins are a relatively unstudied class of sweet compounds that could serve as innovative sweeteners, but their introduction on the food market has been delayed by some factors, among which is the lack of thorough metabolic and toxicological studies. We have tried to shed light on the potential of a sweet protein, MNEI, as a fructose substitute in beverages in a typical western diet, by studying the metabolic consequences of its consumption on a Wistar rat model of high fat diet-induced obesity. In particular, we investigated the lipid profile, insulin sensitivity and other indicators of metabolic syndrome. We also evaluated systemic inflammation and potential colon damage. MNEI consumption rescued the metabolic derangement elicited by the intake of fructose, namely insulin resistance, altered plasma lipid profile, colon inflammation and translocation of lipopolysaccharides from the gut lumen into the circulatory system. We concluded that MNEI could represent a valid alternative to fructose, particularly when concomitant metabolic disorders such as diabetes and/or glucose intolerance are present.

scholarly journals Daily Inclusion of Potatoes Into a Dietary Guidelines for Americans-Based Dietary Pattern Does Not Adversely Impact Cardiometabolic Risk in Adults With Metabolic Syndrome

2021 ◽  
Vol 5 (Supplement_2) ◽  
pp. 300-300
Author(s):  
Sisi Cao ◽  
William Quarles ◽  
Emily Shaw ◽  
Geoffrey Sasaki ◽  
Priyankar Dey ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Endothelial Function ◽  
Resistant Starch ◽  
Dietary Pattern ◽  
Dietary Guidelines ◽  
Cardiometabolic Health ◽  
Oral Glucose ◽  
Vascular Endothelial ◽  
Vascular Endothelial Function ◽  
Dietary Guidelines For Americans

Abstract Objectives Observational studies suggest that the regular ingestion of potatoes adversely affects cardiometabolic health, but controlled studies in humans are needed to establish causality. Our objective was to assess whether daily inclusion of non-fried potato foods as part of a Dietary Guidelines for Americans (DGA)-based dietary pattern would impair cardiometabolic health in adults with metabolic syndrome (MetS). Methods In a 2-arm, randomized controlled, crossover trial separated by a 2-wk washout period, MetS adults were provided a eucaloric DGA-based dietary pattern containing potato (350 g with 17.5 g/d resistant starch; POTATO) or an energy-matched bagel (0 g/d resistant starch; CON) for 14 d. Fasting blood was collected on d 0 and 14. On d 14, after a 75 g oral glucose tolerance test, brachial artery flow-mediated dilation (FMD) was measured and blood was collected at 30 min intervals for 2 h to assess vascular endothelial function and metabolic excursions, respectively. Circulating endotoxin, glucose, insulin, and nitric oxide metabolites (NOx) were assessed by spectrophotometry, and malondialdehyde (MDA) and arginine and its metabolites by HPLC. Data were analyzed using two-way repeated measures ANOVA. Results MetS adults (n = 27; 32.5 ± 1.3 y; 35.0 ± 1.0 kg/m2) completed the study with no adverse effects or significant changes in body weight. The 14-d DGA-based dietary pattern had a small but significant effect to decrease glucose (107 ± 1.9 vs. 102 ± 1.7 mg/dL; P = 0.04) and insulin (19 ± 2.9 vs. 14 ± 1.5 μIU/mL; P = 0.03), but these were unaffected by POTATO. Fasting endotoxin, NOx, and MDA and FMD were also unaffected by POTATO compared to CON, as were postprandial AUC0–2h of FMD, insulin, glucose, arginine, MDA, endotoxin, and NOx. Conclusions Findings of this acute controlled trial, which require long-term validation, support that a DGA-based dietary pattern may help to improve insulin resistance and that potatoes can be effectively incorporated into the diet without compromising vascular endothelial function or cardiometabolic health in persons with MetS. Funding Sources Alliance for Potato Research and Education.

scholarly journals Olive Oil, Palm Oil, and Hybrid Palm Oil Distinctly Modulate Liver Transcriptome and Induce NAFLD in Mice Fed a High-Fat Diet

2018 ◽  
Vol 20 (1) ◽  
pp. 8 ◽  
Author(s):  
Rafael Sales ◽  
Priscylla Medeiros ◽  
Flavia Spreafico ◽  
Patrícia de Velasco ◽  
Fernanda Gonçalves ◽  
...  
Keyword(s):  
Lipid Profile ◽  
Palm Oil ◽  
High Fat Diet ◽  
Protein Localization ◽  
Blood Lipid ◽  
Liver Fat ◽  
High Fat ◽  
Blood Lipid Profile ◽  
High Fat Diets ◽  
Fat Diets

Nonalcoholic fatty liver disease (NAFLD) is highly prevalent worldwide. The most severe form is nonalcoholic steatohepatitis (NASH). Among risk factors for the development of NAFLD is excessive lipid intake. Since palm (P) oil is the most consumed oil in the world, we aimed to investigate the effects of high-fat diets made with P oil, hybrid palm (HP) oil, or olive (O) oil in liver. Twenty-four male mice (C57Bl/6J) were fed a high-fat diet (41% fat) containing P, HP, or O oils for 8 weeks and compared to a control (C) group fed a chow diet. Adiposity was measured with computed tomography. Body, adipose tissue, and liver weights, as well as liver fat (Bligh–Dyer), blood lipid profile, glucose, and liver enzymes were measured. Liver histology (hematoxylin–eosin) and transcriptome (microarray-based) were performed. ANOVA tests with Newman–Keuls were used. Body weight was increased in the P group (p < 0.001) and body fat in the O group (C vs. O p ≤ 0.01, P vs. O p ≤ 0.05, HP vs. O p ≤ 0.05). All high-fat diets disturbed the blood lipid profile and glucose, with marked effects of HP on very low-density lipoprotein cholesterol (VLDL), triglycerides, and alkaline phosphatase (p ≤ 0.001). HP had the highest liver fat (42.76 ± 1.58), followed by P (33.94 ± 1.13). O had a fat amount comparable to C (16.46 ± 0.34, 14.71 ± 0.70, respectively). P and HP oils induced hepatocyte ballooning. Transcriptome alterations of the O group were related to amino acid metabolism and fatty acid (FA) metabolism, the P group to calcium ion homeostasis, and HP oil to protein localization. Both P and HP oils induced NASH in mice via disturbed hepatocyte transcription. This raises concerns about the content of these oils in several industrialized foods.

scholarly journals Diet affects glycosylation of serum proteins in women at risk for cardiometabolic disease

2021 ◽  
Author(s):  
Tyler Kim ◽  
Yixuan Xie ◽  
Qiongyu Li ◽  
Virginia M. Artegoitia ◽  
Carlito B. Lebrilla ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Serum Proteins ◽  
Dietary Guidelines ◽  
Protein Glycosylation ◽  
Post Translational Modification ◽  
Serum Samples ◽  
Post Intervention ◽  
Clinical Trial Registration ◽  
Dietary Guidelines For Americans ◽  
Parametric Analyses

Abstract Background Glycoproteomics deals with glycoproteins that are formed by post-translational modification when sugars (like fucose and sialic acid) are attached to protein. Glycosylation of proteins influences function, but whether glycosylation is altered by diet is unknown. Objective To evaluate the effect of consuming a diet based on the Dietary Guidelines for Americans on circulating glycoproteins that have previously been associated with cardiometabolic diseases. Design Forty-four women, with one or more metabolic syndrome characteristics, completed an 8-week randomized controlled feeding intervention (n = 22) consuming a diet based on the Dietary Guidelines for Americans (DGA 2010); the remaining consumed a ‘typical American diet’ (TAD, n = 22). Fasting serum samples were obtained at week0 (baseline) and week8 (post-intervention); 17 serum proteins were chosen for targeted analyses. Protein standards and serum samples were analyzed in a UHPLC-MS protocol to determine peptide concentration and their glycan (fucosylation or sialylation) profiles. Data at baseline were used in correlational analyses; change in proteins and glycans following intervention were used in non-parametric analyses. Results At baseline, women with more metabolic syndrome characteristics had more fucosylation (total di-fucosylated proteins: p = 0.045) compared to women with a lesser number of metabolic syndrome characteristics. Dietary refined grain intake was associated with increased total fucosylation (ρ = − 0.530, p < 0.001) and reduced total sialylation (ρ = 0.311, p = 0.042). After the 8-week intervention, there was higher sialylation following the DGA diet (Total di-sialylated protein p = 0.018, poly-sialylated orosomucoid p = 0.012) compared to the TAD diet. Conclusions Based on this study, glycosylation of proteins is likely affected by dietary patterns; higher sialylation was associated with a healthier diet pattern. Altered glycosylation is associated with several diseases, particularly cancer and type 2 diabetes, and this study raises the possibility that diet may influence disease state by altering glycosylation. Clinical trial registration NCT02298725 at clinicaltrials.gov; https://clinicaltrials.gov/ct2/show/NCT02298725.

scholarly journals Therapeutic Effects of Lithospermate B Complexed with Mg2+ or Zn2+ on Metabolic Syndrome Induced in Rats Fed with High-Fat Diet

Molecules ◽  
2020 ◽  
Vol 25 (4) ◽  
pp. 983 ◽  
Author(s):  
Sheng-Kuo Hsieh ◽  
Nan-Hei Lin ◽  
Ying-Jie Chen ◽  
Maw-Rong Lee ◽  
Wen-Ying Chen ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
High Fat Diet ◽  
Proinflammatory Cytokine ◽  
Blood Lipid ◽  
Therapeutic Effects ◽  
High Fat ◽  
Modern Life ◽  
Magnesium Lithospermate B ◽  
And Oxidative Stress ◽  
Better Than

Excessive food consumption and insufficient exercise lead to the prevalence of metabolic syndrome in modern life, which consequently increases the risk of many chronic diseases. Magnesium lithospermate B (MLB) from Danshen has been demonstrated to improve metabolic changes in high-fat diet–fed rats with metabolic syndrome. In this study, Mg2+ in MLB was successfully replaced with Zn2+ to form zinc lithospermate B (ZLB) complex. MLB (10 mg/kg /day) and ZLB of various concentrations (1, 2.5, 5, and 10 mg/kg/day) were prepared and examined for their therapeutic effects on metabolic syndrome induced in rats fed with a high-fat diet. The results showed that both MLB and ZLB were able to recover or alleviate the abnormal physiological states of high-fat diet–fed rats including weight gain, epididymal fat accumulation, fatty liver, retarded blood lipid and glucose metabolism putatively caused by insulin resistance, and elevated levels of proinflammatory cytokine, leptin, and oxidative stress. In an overall view of the animal study, the effectiveness of ZLB supplementation seemed to be better than that of MLB supplementation for the recovery of high-fat-fed rats from metabolic syndrome.

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