Calcineurin inhibitors and renal biopsy in children with idiopathic nephrotic syndrome

2021 ◽  
Author(s):  
Wael Abukwaik ◽  
Janet M. Poulik ◽  
Tej K. Mattoo
Keyword(s):  
Nephrotic Syndrome ◽  
Renal Biopsy ◽  
Idiopathic Nephrotic Syndrome ◽  
Calcineurin Inhibitors

scholarly journals Apheresis Therapy for Steroid-Resistant Idiopathic Nephrotic Syndrome: Report on a Case Series

2019 ◽  
Vol 2019 ◽  
pp. 1-4
Author(s):  
Hamza Naciri Bennani ◽  
Thomas Jouve ◽  
Johan Noble ◽  
Lionel Rostaing ◽  
Paolo Malvezzi ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Minimal Change Disease ◽  
Idiopathic Nephrotic Syndrome ◽  
Case Series ◽  
Calcineurin Inhibitors ◽  
Multidrug Resistant ◽  
Glomerular Permeability ◽  
Steroid Resistant ◽  
Double Filtration Plasmapheresis ◽  
Double Filtration

Idiopathic nephrotic syndrome (INS) represents 15%–30% of adulthood glomerulopathies. Corticosteroids have been the main treatment for decades and are effective in 70% of minimal-change disease patients and ~30% of focal segmental glomerulosclerosis patients. Multidrug-resistant (steroids, calcineurin-inhibitors, cyclophosphamide, mycophenolate-mofetil, rituximab) idiopathic nephrotic syndrome is a major therapeutic challenge in nephrology. Apheresis (double-filtration plasmapheresis or semi specific immunoadsorption) could act by eliminating the circulating factor (apolipoproteinA1b, solubleCD40L, suPAR) increasing glomerular permeability seen in INS. The aim of the study was to report the outcome of three patients with multidrug-resistant INS treated successfully with apheresis.

scholarly journals Renal Biopsy: Use of Biomarkers as a Tool for the Diagnosis of Focal Segmental Glomerulosclerosis

2014 ◽  
Vol 2014 ◽  
pp. 1-11 ◽  
Author(s):  
Crislaine Aparecida da Silva ◽  
Mariana Molinar Mauad Cintra ◽  
Eliângela de Castro Côbo ◽  
Marcos Vinícius da Silva ◽  
Fabiano Bichuette Custódio ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Renal Biopsy ◽  
Focal Segmental Glomerulosclerosis ◽  
Idiopathic Nephrotic Syndrome ◽  
Biological Molecules ◽  
Podocyte Injury ◽  
Segmental Glomerulosclerosis ◽  
Morphological Diagnosis ◽  
Potential Use

Focal segmental glomerulosclerosis (FSGS) is a glomerulopathy associated with nephrotic syndrome and podocyte injury. FSGS occurs both in children and adults and it is considered the main idiopathic nephrotic syndrome nowadays. It is extremely difficult to establish a morphological diagnosis, since some biopsies lack a considerable quantifiable number of sclerotic glomeruli, given their focal aspect and the fact that FSGS occurs in less than half of the glomeruli. Therefore, many biological molecules have been evaluated as potential markers that would enhance the diagnosis of FSGS. Some of these molecules and receptors are associated with the pathogenesis of FSGS and have potential use in diagnosis.

Incidental detection of oncocytosis in a renal biopsy specimen for idiopathic nephrotic syndrome

2011 ◽  
Vol 207 (11) ◽  
pp. 733-736 ◽  
Author(s):  
J. Fernando Val-Bernal ◽  
Emilio Rodrigo ◽  
Jorge Ruiz-Criado ◽  
M. Francisca Garijo ◽  
Josefina Martín-Gago ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Renal Biopsy ◽  
Biopsy Specimen ◽  
Idiopathic Nephrotic Syndrome ◽  
Renal Biopsy Specimen

Renal biopsy criterion in idiopathic nephrotic syndrome with microscopic hematuria at onset

2014 ◽  
Vol 30 (3) ◽  
pp. 445-450 ◽  
Author(s):  
Taketsugu Hama ◽  
Koichi Nakanishi ◽  
Yuko Shima ◽  
Masashi Sato ◽  
Hironobu Mukaiyama ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Renal Biopsy ◽  
Idiopathic Nephrotic Syndrome ◽  
Microscopic Hematuria
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