002 Influence of a renal biopsy result on treatment and management of steroid-resistant, idiopathic nephrotic syndrome in children

2018 ◽  
Author(s):  
H Webb ◽  
S McKeever
Keyword(s):  
Nephrotic Syndrome ◽  
Renal Biopsy ◽  
Idiopathic Nephrotic Syndrome ◽  
Biopsy Result ◽  
Steroid Resistant

scholarly journals Urinary Extracellular Vesicle Protein Profiles Discriminate Different Clinical Subgroups of Children with Idiopathic Nephrotic Syndrome

Diagnostics ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 456
Author(s):  
Lucia Santorelli ◽  
William Morello ◽  
Elisa Barigazzi ◽  
Giulia Capitoli ◽  
Chiara Tamburello ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Idiopathic Nephrotic Syndrome ◽  
Protein Profile ◽  
Therapy Response ◽  
Extracellular Vesicle ◽  
Distinct Pattern ◽  
Specific Patient ◽  
Steroid Resistant ◽  
Primary Glomerular Disease ◽  
Disease Signature

Idiopathic nephrotic syndrome (INS) is the most frequent primary glomerular disease in children, displaying high grade proteinuria and oedema. The mainstay of therapy are steroids, and patients are usually classified according to the treatment response (sensitive vs. resistant). The mechanisms involved in INS pathogenesis and treatment responsiveness have not yet been identified. In this context, the analysis of urinary extracellular vesicles (UEv) is interesting, since they represent a molecular snapshot of the parental cells, offering a “fingerprint” for monitoring their status. Therefore, the aim of this study is to verify the feasibility of using UEv of INS patients as indicators of therapy response and its prediction. UEv were isolated from the urine of pediatric patients in remission after therapy; they showed characteristic electrophoresis profiles that matched specific patient subgroups. We then built a statistical model to interpret objectively each patient UEv protein profile: in particular, steroid-resistant patients cluster together with a very distinct pattern from other INS patients and controls. In conclusion, the evaluation of the UEv protein profile looks promising in the investigation of INS, showing a disease signature that might predict clinical evolution.

Hodgkin's disease following steroid-resistant idiopathic nephrotic syndrome

1994 ◽  
Vol 8 (3) ◽  
pp. 395-396
Author(s):  
Georges Desch�nes ◽  
Christophe Allard ◽  
St�phane Benoit ◽  
Odile Lejars ◽  
Jean Pierre Lamagnere ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Hodgkin's Disease ◽  
Idiopathic Nephrotic Syndrome ◽  
Hodgkin’S Disease ◽  
Steroid Resistant

Urinary Proteome of Steroid-Sensitive and Steroid-Resistant Idiopathic Nephrotic Syndrome of Childhood

2006 ◽  
Vol 26 (3) ◽  
pp. 258-267 ◽  
Author(s):  
Robert P. Woroniecki ◽  
Tatyana N. Orlova ◽  
Natasha Mendelev ◽  
Ibrahim F. Shatat ◽  
Susan M. Hailpern ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Idiopathic Nephrotic Syndrome ◽  
Steroid Resistant ◽  
Urinary Proteome ◽  
Steroid Sensitive
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