Incidental detection of oncocytosis in a renal biopsy specimen for idiopathic nephrotic syndrome

2011 ◽  
Vol 207 (11) ◽  
pp. 733-736 ◽  
Author(s):  
J. Fernando Val-Bernal ◽  
Emilio Rodrigo ◽  
Jorge Ruiz-Criado ◽  
M. Francisca Garijo ◽  
Josefina Martín-Gago ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Renal Biopsy ◽  
Biopsy Specimen ◽  
Idiopathic Nephrotic Syndrome ◽  
Renal Biopsy Specimen

scholarly journals MPGN Type 3 Associated with Pemphigus Herpetiformis Mimicking PGNMID and Dermatitis Herpetiformis

2019 ◽  
Vol 9 (1) ◽  
pp. 15-24
Author(s):  
Yoshio Shimizu ◽  
Keiichi Wakabayashi ◽  
Yoko Hayashi ◽  
Kazuaki Hara ◽  
Rumi Aoyama ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Renal Biopsy ◽  
Biopsy Specimen ◽  
Dermatitis Herpetiformis ◽  
Complex Type ◽  
Renal Abnormality ◽  
Renal Disorder ◽  
Renal Biopsy Specimen ◽  
Blistering Disease ◽  
Type 3

A 45-year-old man suffering from dermal blistering disease with proteinuria and hematuria underwent renal biopsy. The renal biopsy specimen suggested proliferative glomerulonephritis with monoclonal IgG deposits under routine light, immunofluorescence and electron microscopy. The staining for IgG subclasses (IgG1 and IgG2) and κ/λ light chain indicated secondary immune complex type MPGN type 3. The patient had been diagnosed as having dermatitis herpetiformis (DH), a phenotype of gluten hypersensitivity prior to the appearance of the renal abnormality. Although common autoantibodies might be related to the pathogenesis of disorders in the skin and kidney, DH is mainly driven by IgA autoantibody, while MPGN is induced by IgG immune complexes. IgA was not observed in the glomeruli by immunofluorescence. Neither the examination for DH specific autoantibodies nor HLA-DQB1 genotype supported the diagnosis of DH. Reassessment of the skin biopsy record revealed that the blister was localized in the epidermis, suggesting pemphigus herpetiformis by IgG class anti-epidermal autoantibody, which also affected the renal disorder.

scholarly journals Renal Biopsy: Use of Biomarkers as a Tool for the Diagnosis of Focal Segmental Glomerulosclerosis

2014 ◽  
Vol 2014 ◽  
pp. 1-11 ◽  
Author(s):  
Crislaine Aparecida da Silva ◽  
Mariana Molinar Mauad Cintra ◽  
Eliângela de Castro Côbo ◽  
Marcos Vinícius da Silva ◽  
Fabiano Bichuette Custódio ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Renal Biopsy ◽  
Focal Segmental Glomerulosclerosis ◽  
Idiopathic Nephrotic Syndrome ◽  
Biological Molecules ◽  
Podocyte Injury ◽  
Segmental Glomerulosclerosis ◽  
Morphological Diagnosis ◽  
Potential Use

Focal segmental glomerulosclerosis (FSGS) is a glomerulopathy associated with nephrotic syndrome and podocyte injury. FSGS occurs both in children and adults and it is considered the main idiopathic nephrotic syndrome nowadays. It is extremely difficult to establish a morphological diagnosis, since some biopsies lack a considerable quantifiable number of sclerotic glomeruli, given their focal aspect and the fact that FSGS occurs in less than half of the glomeruli. Therefore, many biological molecules have been evaluated as potential markers that would enhance the diagnosis of FSGS. Some of these molecules and receptors are associated with the pathogenesis of FSGS and have potential use in diagnosis.

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