Vergleich von spezifischen IgE-Messungen mit den Einzelallergenträgern Der p1, Der p2, dem Cocktail-Allergenträger Der p1/Der p2, den Einzelallergenen Phl p1 und Phl p5 sowie mit Extrakten aus Dermatophagoides pteronyssinus und Phleum pratense-P

Allergologie ◽  
2015 ◽  
Vol 38 (10) ◽  
pp. 498-506
Author(s):  
R. Wahl ◽  
A. Stanek ◽  
R. Krause
Keyword(s):  
Dermatophagoides Pteronyssinus ◽  
Phleum Pratense ◽  
Der P2 ◽  
Der P1

The Dermatophagoides pteronyssinus Molecular Sensitization Profile of Allergic Rhinitis Patients in Central China

2018 ◽  
Vol 32 (5) ◽  
pp. 397-403 ◽  
Author(s):  
Yongshi Yang ◽  
Rongfei Zhu ◽  
Nan Huang ◽  
Wenjing Li ◽  
Wei Zhang ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Immunoglobulin E ◽  
Dermatophagoides Pteronyssinus ◽  
Mite Species ◽  
Cross Reactivity ◽  
Central China ◽  
House Dust Mites ◽  
Positive Skin ◽  
Der P2 ◽  
Der P1

Background House dust mites (HDMs) are the major aeroallergens in patients with rhinitis and/or asthma in China. However, the molecular sensitization of HDM is varied in different regions. Objective To investigate the Dermatophagoides pteronyssinus ( Der p) molecular sensitization profile of allergic rhinitis (AR) patients in Central China. Methods AR patients with positive skin prick tests to Der p were enrolled in our study. Specific immunoglobulin E (sIgE) for Der p, Dermatophagoides farinae ( Der f), Acarus siro ( Aca s), Blomia tropicalis ( Blo t), and Der p components Der p1, Der p2, and Der p10 were measured in all patients. Results A total of 130 patients were included. The overall prevalence of positive serum sIgE was 99.2% for Der p, 98.5% for Der f, 81.5% for Aca s, 83.1% for Blo t, 71.5% for Der p1, 64.6% for Der p2, and 11.5% for Der p10. HDM-AR patients with asthma displayed significantly higher concentrations of sIgE to Der p, Der f, Der p1, and Der p2 than did those without asthma ( P < .001). The prevalence of asthma in HDM-AR patients was higher among the patients sensitized to both Der p1 and Der p2 (62.8%) than those sensitized to only 1 allergen ( Der p1 26.7% or Der p2 16.7%; P < .05) or nonsensitized to Der p1 and Der p2 (19.4%; P < .001). Conclusion Der p has high cross-reactivity with other mite species. Der p1 and Der p2 are the major components to induce Der p sensitization among AR patients in Central China. Sensitization to both Der p1 and Der p2 may be a risk factor for developing asthma in HDM-AR patients.

scholarly journals Der p1 and Der p2-Specific T Cells Display a Th2, Th17, and Th2/Th17 Phenotype in Atopic Dermatitis

2015 ◽  
Vol 135 (9) ◽  
pp. 2324-2327 ◽  
Author(s):  
Lennart M. Roesner ◽  
Annice Heratizadeh ◽  
Gabriele Begemann ◽  
Petra Kienlin ◽  
Susanne Hradetzky ◽  
...  
Keyword(s):  
T Cells ◽  
Atopic Dermatitis ◽  
Der P2 ◽  
Der P1

scholarly journals 8 Allergenic Composition of Polymerized Allergen Extracts of Betula verrucosa, Dermatophagoides Pteronyssinus and Phleum Pratense

2012 ◽  
Vol 5 ◽  
pp. S3
Author(s):  
Enrique Fernandez-Caldas ◽  
Barbara Cases ◽  
Jose Ignacio Tudela ◽  
Eva Abel Fernandez ◽  
Miguel Casanovas ◽  
...  
Keyword(s):  
Dermatophagoides Pteronyssinus ◽  
Phleum Pratense ◽  
Betula Verrucosa ◽  
Allergen Extracts

Dermatophagoides pteronyssinus 2 regulates nerve growth factor release to induce airway inflammation via a reactive oxygen species-dependent pathway

2011 ◽  
Vol 300 (2) ◽  
pp. L216-L224 ◽  
Author(s):  
Yi-Ling Ye ◽  
Hung-Tsung Wu ◽  
Chiou-Feng Lin ◽  
Chia-Yuan Hsieh ◽  
Jiu-Yao Wang ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Nerve Growth Factor ◽  
Growth Factor ◽  
Airway Inflammation ◽  
Dermatophagoides Pteronyssinus ◽  
Ros Production ◽  
Oxygen Species ◽  
Nerve Growth ◽  
Der P2 ◽  
Dependent Pathway

Group 2 allergen of Dermatophagoides pteronyssinus 2 (Der p2) induces airway inflammation without protease activity, and elevated nerve growth factor (NGF) levels are also found in this inflammation. How the allergen Der p2 regulates NGF release via reactive oxygen species (ROS) to induce inflammation remains unclear. In the present study, intratracheal administration of Der p2 to mice led to inflammatory cell infiltration, mucus gland hyperplasia, and NGF upregulation in the bronchial epithelium, as well as elevated ROS and NGF production in bronchoalveolar lavage fluids. In addition, Der p2 caused fibrocyte accumulation and mild fibrosis. p38 mitogen-activated protein kinase (MAPK) and c-Jun N-terminal kinase (JNK) inhibitors inhibited Der p2-induced NGF release in LA4 lung epithelial cells and MLg lung fibroblasts. Pretreatment with an antioxidant, tiron, reduced the Der p2-induced ROS production, NGF expression and release, p38 MAPK or JNK phosphorylation, and airway inflammation. These results suggest that Der p2 allergen-induced airway inflammation and elevated NGF release were through increasing ROS production and a MAPK-dependent pathway. The use of an antioxidant, tiron, may provide a new therapeutic modality for the treatment of allergic asthma.

scholarly journals IgE and IgG4 Repertoire in Asymptomatic HDM-Sensitized and HDM-Induced Allergic Rhinitis Patients

2021 ◽  
pp. 1-12
Author(s):  
Qingxiu Xu ◽  
Qing Jiang ◽  
Lin Yang ◽  
Wenjing Li ◽  
Nan Huang ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Specific Ige ◽  
Basophil Activation ◽  
Control Group ◽  
Positive Skin Prick Test ◽  
Positive Skin ◽  
Allergic Symptoms ◽  
Der P2 ◽  
Der P1 ◽  
Asymptomatic Subjects

<b><i>Introduction:</i></b> Asymptomatic sensitization is defined as the presence of positive skin prick test (SPT) and/or positive serum allergen-specific IgE in the absence of clinical allergic symptoms. Currently, there is no convincing explanation why some people with positive allergen tests do not show symptoms. We aimed to investigate the house dust mite (HDM)-specific IgE and IgG4 repertoire in asymptomatic HDM-sensitized subjects and HDM-induced allergic rhinitis (AR) patients. <b><i>Methods:</i></b> A total of 48 subjects sensitized to HDM were included in this study: 27 had AR with/without asthma (symptomatic group), and 21 had no allergic symptoms (asymptomatic group). Six healthy individuals served as control group. Peripheral blood samples were collected for serum IgE and IgG4 assay and basophil activation tests (BATs). IgE and IgG4 assay included antibodies to <i>Dermatophagoides</i> (<i>Der</i>) <i>p1</i>, <i>2</i>, <i>7</i>, <i>10</i>, <i>21</i>, <i>23</i>, and <i>Der f1</i>, <i>2</i>. <b><i>Results:</i></b> AR patients had a larger wheal diameter of SPT (7.0 vs. 3.0 mm, <i>p</i> &#x3c; 0.0001) and a higher specific IgE to <i>Der p</i> (15.50 vs. 0.70 KU/L, <i>p</i> &#x3c; 0.0001) than asymptomatic subjects. They also showed more frequent sensitization to <i>Der p1</i> and <i>Der p2</i> (both <i>p</i> &#x3c; 0.05). However, the total IgE and specific IgG4 did not differ significantly between the 2 groups. The basophil activation response after being stimulated with HDM was observed to be higher in AR patients (all <i>p</i> &#x3c; 0.05). <b><i>Conclusions:</i></b> There are differences in SPT, serum-specific IgE to <i>Der p</i>, component allergen <i>Der p1</i> and <i>Der p2</i> level and BAT between AR patients and asymptomatic subjects sensitized to HDM. IgG4 alone cannot differentiate asymptomatic individuals from AR patients.

scholarly journals Serum and Salivary IgE, IgA, andIgG4Antibodies toDermatophagoides pteronyssinusand Its Major Allergens, Der p1 and Der p2, in Allergic and Nonallergic Children

2011 ◽  
Vol 2011 ◽  
pp. 1-11 ◽  
Author(s):  
Diego O. Miranda ◽  
Deise A. O. Silva ◽  
Jorge F. C. Fernandes ◽  
Meimei G. J. Queirós ◽  
Hamilton F. Chiba ◽  
...  
Keyword(s):  
Sublingual Immunotherapy ◽  
Public Health Problem ◽  
Specific Ige ◽  
Healthy Children ◽  
High Prevalence ◽  
Der P2 ◽  
Iga Antibodies ◽  
Dust Mite ◽  
Der P1 ◽  
Major Allergens

Allergic rhinitis (AR) is a public health problem with high prevalence worldwide. We evaluated levels of specific IgE, IgA, and IgG4 antibodies to theDermatophagoides pteronyssinus(Dpt) house dust mite and to its major allergens (Der p1 and Der p2) in serum and saliva samples from allergic and nonallergic children. A total of 86 children were analyzed, from which 72 had AR and 14 were nonallergic healthy children. Serum IgE and serum/salivary IgG4 levels to Dpt, Der p1, and Der p2 were higher in allergic children whereas serum/salivary IgA levels to all allergens were higher in nonallergic children. IgE levels positively correlated with IgG4 and IgA to all allergens in allergic children, while IgA levels negatively correlated with IgG4 to Dpt and Der p1 in nonallergic children. In conclusion, mite-specific IgA antibodies predominate in the serum and saliva of nonallergic children whereas mite-specific IgE and IgG4 are prevalent in allergic children. The presence of specific IgA appears to have a key role for the healthy immune response to mucosal allergens. Also, specific IgA measurements in serum and/or saliva may be useful for monitoring activation of tolerance-inducing mechanisms during allergen specific immunotherapeutic procedures, especially sublingual immunotherapy.

scholarly journals House Dust Mite Allergy and the Der p1 Conundrum: A Literature Review and Case Series

Allergies ◽  
2021 ◽  
Vol 1 (2) ◽  
pp. 108-114
Author(s):  
Miriana d’Alessandro ◽  
Laura Bergantini ◽  
Anna Perrone ◽  
Paolo Cameli ◽  
Valerio Beltrami ◽  
...  
Keyword(s):  
House Dust ◽  
House Dust Mite ◽  
Case Series ◽  
Specific Ige ◽  
House Dust Mite Allergy ◽  
Mite Allergy ◽  
Der P2 ◽  
Dust Mite ◽  
Der P1

The house dust mite (HDM) is globally ubiquitous in human habitats. Thirty-two allergens for Dermatophagoides farinae and 21 for Dermatophagoides pteronyssinus have been detected so far. The present minireview summarizes information about the role of Der p 1 as a key coordinator of the HDM-induced allergic response and reports on a series of Italian patients who are allergic to HDMs. We studied the specific IgE profiles in a population of patients with allergic asthma and rhinitis screened for specific immunotherapy (SIT) for HDM allergies, with the aim of obtaining insights into the pathogenic role of Der p1. Patients co-sensitized to other airborne allergens showed a higher prevalence of asthma (9/12 (75%) vs. 2/7 (29%); p < 0.05) than did HDM mono-sensitized patients. The latter group showed higher Der p1 concentrations than that of the co-sensitized group (p = 0.0360), and a direct correlation between Der p1 and Der p2 (r = 0.93; p = 0.0003) was observed. In conclusion, our study offers insights into the role of Der p1 in a population of patients with allergic rhinitis and asthma who were candidates for SIT. Interestingly, Der p1 positivity was associated with bronchial asthma and co-sensitization.

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