scholarly journals Serum and Salivary IgE, IgA, andIgG4Antibodies toDermatophagoides pteronyssinusand Its Major Allergens, Der p1 and Der p2, in Allergic and Nonallergic Children

2011 ◽  
Vol 2011 ◽  
pp. 1-11 ◽  
Author(s):  
Diego O. Miranda ◽  
Deise A. O. Silva ◽  
Jorge F. C. Fernandes ◽  
Meimei G. J. Queirós ◽  
Hamilton F. Chiba ◽  
...  
Keyword(s):  
Sublingual Immunotherapy ◽  
Public Health Problem ◽  
Specific Ige ◽  
Healthy Children ◽  
High Prevalence ◽  
Der P2 ◽  
Iga Antibodies ◽  
Dust Mite ◽  
Der P1 ◽  
Major Allergens

Allergic rhinitis (AR) is a public health problem with high prevalence worldwide. We evaluated levels of specific IgE, IgA, and IgG4 antibodies to theDermatophagoides pteronyssinus(Dpt) house dust mite and to its major allergens (Der p1 and Der p2) in serum and saliva samples from allergic and nonallergic children. A total of 86 children were analyzed, from which 72 had AR and 14 were nonallergic healthy children. Serum IgE and serum/salivary IgG4 levels to Dpt, Der p1, and Der p2 were higher in allergic children whereas serum/salivary IgA levels to all allergens were higher in nonallergic children. IgE levels positively correlated with IgG4 and IgA to all allergens in allergic children, while IgA levels negatively correlated with IgG4 to Dpt and Der p1 in nonallergic children. In conclusion, mite-specific IgA antibodies predominate in the serum and saliva of nonallergic children whereas mite-specific IgE and IgG4 are prevalent in allergic children. The presence of specific IgA appears to have a key role for the healthy immune response to mucosal allergens. Also, specific IgA measurements in serum and/or saliva may be useful for monitoring activation of tolerance-inducing mechanisms during allergen specific immunotherapeutic procedures, especially sublingual immunotherapy.

scholarly journals House Dust Mite Allergy and the Der p1 Conundrum: A Literature Review and Case Series

Allergies ◽  
2021 ◽  
Vol 1 (2) ◽  
pp. 108-114
Author(s):  
Miriana d’Alessandro ◽  
Laura Bergantini ◽  
Anna Perrone ◽  
Paolo Cameli ◽  
Valerio Beltrami ◽  
...  
Keyword(s):  
House Dust ◽  
House Dust Mite ◽  
Case Series ◽  
Specific Ige ◽  
House Dust Mite Allergy ◽  
Mite Allergy ◽  
Der P2 ◽  
Dust Mite ◽  
Der P1

The house dust mite (HDM) is globally ubiquitous in human habitats. Thirty-two allergens for Dermatophagoides farinae and 21 for Dermatophagoides pteronyssinus have been detected so far. The present minireview summarizes information about the role of Der p 1 as a key coordinator of the HDM-induced allergic response and reports on a series of Italian patients who are allergic to HDMs. We studied the specific IgE profiles in a population of patients with allergic asthma and rhinitis screened for specific immunotherapy (SIT) for HDM allergies, with the aim of obtaining insights into the pathogenic role of Der p1. Patients co-sensitized to other airborne allergens showed a higher prevalence of asthma (9/12 (75%) vs. 2/7 (29%); p < 0.05) than did HDM mono-sensitized patients. The latter group showed higher Der p1 concentrations than that of the co-sensitized group (p = 0.0360), and a direct correlation between Der p1 and Der p2 (r = 0.93; p = 0.0003) was observed. In conclusion, our study offers insights into the role of Der p1 in a population of patients with allergic rhinitis and asthma who were candidates for SIT. Interestingly, Der p1 positivity was associated with bronchial asthma and co-sensitization.

scholarly journals IgE and IgG4 Repertoire in Asymptomatic HDM-Sensitized and HDM-Induced Allergic Rhinitis Patients

2021 ◽  
pp. 1-12
Author(s):  
Qingxiu Xu ◽  
Qing Jiang ◽  
Lin Yang ◽  
Wenjing Li ◽  
Nan Huang ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Specific Ige ◽  
Basophil Activation ◽  
Control Group ◽  
Positive Skin Prick Test ◽  
Positive Skin ◽  
Allergic Symptoms ◽  
Der P2 ◽  
Der P1 ◽  
Asymptomatic Subjects

<b><i>Introduction:</i></b> Asymptomatic sensitization is defined as the presence of positive skin prick test (SPT) and/or positive serum allergen-specific IgE in the absence of clinical allergic symptoms. Currently, there is no convincing explanation why some people with positive allergen tests do not show symptoms. We aimed to investigate the house dust mite (HDM)-specific IgE and IgG4 repertoire in asymptomatic HDM-sensitized subjects and HDM-induced allergic rhinitis (AR) patients. <b><i>Methods:</i></b> A total of 48 subjects sensitized to HDM were included in this study: 27 had AR with/without asthma (symptomatic group), and 21 had no allergic symptoms (asymptomatic group). Six healthy individuals served as control group. Peripheral blood samples were collected for serum IgE and IgG4 assay and basophil activation tests (BATs). IgE and IgG4 assay included antibodies to <i>Dermatophagoides</i> (<i>Der</i>) <i>p1</i>, <i>2</i>, <i>7</i>, <i>10</i>, <i>21</i>, <i>23</i>, and <i>Der f1</i>, <i>2</i>. <b><i>Results:</i></b> AR patients had a larger wheal diameter of SPT (7.0 vs. 3.0 mm, <i>p</i> &#x3c; 0.0001) and a higher specific IgE to <i>Der p</i> (15.50 vs. 0.70 KU/L, <i>p</i> &#x3c; 0.0001) than asymptomatic subjects. They also showed more frequent sensitization to <i>Der p1</i> and <i>Der p2</i> (both <i>p</i> &#x3c; 0.05). However, the total IgE and specific IgG4 did not differ significantly between the 2 groups. The basophil activation response after being stimulated with HDM was observed to be higher in AR patients (all <i>p</i> &#x3c; 0.05). <b><i>Conclusions:</i></b> There are differences in SPT, serum-specific IgE to <i>Der p</i>, component allergen <i>Der p1</i> and <i>Der p2</i> level and BAT between AR patients and asymptomatic subjects sensitized to HDM. IgG4 alone cannot differentiate asymptomatic individuals from AR patients.

Predicting Shrimp Allergy Using Skin Prick Test, Specific IgE to Shrimp and Rpen a1 in Area with High Prevalence of House Dust Mite Sensitization

2015 ◽  
Vol 135 (2) ◽  
pp. AB248
Author(s):  
Jaichat Mekaroonkamol ◽  
Pantipa Chatchatee ◽  
Jarungchit Ngamphaiboon ◽  
Piyawadee Lertchanaruengrith ◽  
Narissara Suratannon
Keyword(s):  
Skin Prick Test ◽  
House Dust ◽  
House Dust Mite ◽  
Specific Ige ◽  
Prick Test ◽  
High Prevalence ◽  
Dust Mite

The Prevalence of Vitamin D Deficiency in Iran: A Literature Review

2020 ◽  
Vol 16 (7) ◽  
pp. 1015-1027
Author(s):  
Mohammad Bagherniya ◽  
Zahra Khorasanchi ◽  
Mina S. Bidokhti ◽  
Gordon A. Ferns ◽  
Mitra Rezaei ◽  
...  
Keyword(s):  
Vitamin D ◽  
Literature Review ◽  
Vitamin D Deficiency ◽  
Medical Condition ◽  
Scientific Information ◽  
Age Groups ◽  
Public Health Problem ◽  
Major Public Health Problem ◽  
Vitamin D Levels ◽  
High Prevalence

Background: Vitamin D deficiency is a common medical condition worldwide. In Iran, it has been reported that between 30-90% of people have vitamin D deficiency. However, its distribution in different parts of the country and among different age and regional groups is unclear. Therefore, the aim of this study was to review the recent literature on vitamin D deficiency in Iran. Methods: The literature review was performed using Web of Science, PubMed-Medline, Scopus and Scientific Information Database (SID) with a cut-off date of November 2016 to identify articles on vitamin D status in Iran published in the last 10 years. Studies in English and Persian that reported vitamin D levels in male and female subjects of all age groups and in healthy populations were included. Results: From 325 studies that were initially retrieved, 82 articles met the inclusion criteria. A high prevalence of vitamin D deficiency was reported, and in some regions, this was reported as >90% and was found in all age groups and in all regions of Iran. Conclusion: This review highlights the very high prevalence of vitamin D deficiency in Iran. It will be important to recognize the importance of vitamin D deficiency as a major public health problem in Iran.

scholarly journals A Systematic Review and Meta-Analysis of Pharmacogenetic Studies in Patients with Chronic Kidney Disease

2021 ◽  
Vol 22 (9) ◽  
pp. 4480
Author(s):  
Maria Tziastoudi ◽  
Georgios Pissas ◽  
Georgios Raptis ◽  
Christos Cholevas ◽  
Theodoros Eleftheriadis ◽  
...  
Keyword(s):  
Systematic Review ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Meta Analysis ◽  
Public Health Problem ◽  
Response To Treatment ◽  
Genotype Distribution ◽  
Global Public Health ◽  
High Prevalence ◽  
Additive Inheritance

Chronic kidney disease (CKD) is an important global public health problem due to its high prevalence and morbidity. Although the treatment of nephrology patients has changed considerably, ineffectiveness and side effects of medications represent a major issue. In an effort to elucidate the contribution of genetic variants located in several genes in the response to treatment of patients with CKD, we performed a systematic review and meta-analysis of all available pharmacogenetics studies. The association between genotype distribution and response to medication was examined using the dominant, recessive, and additive inheritance models. Subgroup analysis based on ethnicity was also performed. In total, 29 studies were included in the meta-analysis, which examined the association of 11 genes (16 polymorphisms) with the response to treatment regarding CKD. Among the 29 studies, 18 studies included patients with renal transplantation, 8 involved patients with nephrotic syndrome, and 3 studies included patients with lupus nephritis. The present meta-analysis provides strong evidence for the contribution of variants harbored in the ABCB1, IL-10, ITPA, MIF, and TNF genes that creates some genetic predisposition that reduces effectiveness or is associated with adverse events of medications used in CKD.

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