scholarly journals Automated Determination of Bone Age in a Modern Chinese Population

2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
Shao-Yan Zhang ◽  
Gang Liu ◽  
Chen-Guo Ma ◽  
Yi-San Han ◽  
Xun-Zhang Shen ◽  
...  

Rationale and Objective. Large studies have previously been performed to set up a Chinese bone age reference, but it has been difficult to compare the maturation of Chinese children with populations elsewhere due to the potential variability between raters in different parts of the world. We re-analysed the radiographs from a large study of normal Chinese children using an automated bone age rating method to establish a Chinese bone age reference, and to compare the tempo of maturation in the Chinese with other populations. Materials and Methods. X-rays from 2883 boys and 3143 girls aged 2–20 years from five Chinese cities, taken in 2005, were evaluated using the BoneXpert automated method. Results. Chinese children reached full maturity at the same age as previously studied Asian children from Los Angeles, but 0.6 years earlier than Caucasian children in Los Angeles. The Greulich-Pyle bone age method was adapted to the Chinese population creating a new bone age scale BX-China05. The standard deviation between BX-China05 and chronologic age was 1.01 years in boys aged 8–14, and 1.08 years in girls aged 7–12. Conclusion. By eliminating rater variability, the automated method provides a reliable and efficient standard for bone age determination in China.

2016 ◽  
Vol 131 (3) ◽  
pp. 771-780 ◽  
Author(s):  
Hans Henrik Thodberg ◽  
Rick R. van Rijn ◽  
Oskar G. Jenni ◽  
David. D. Martin

2010 ◽  
Vol 37 (12) ◽  
pp. 3048-3058 ◽  
Author(s):  
Stefano De Luca ◽  
Inmaculada Alemán ◽  
Francesca Bertoldi ◽  
Luigi Ferrante ◽  
Paola Mastrangelo ◽  
...  

Author(s):  
Alexander M. Nedzved ◽  
Ivan I. Kosik ◽  
Ryhor M. Karapetsian

In this paper, we investigate the urgent problem associated with bone age determination using hand X-rays. A combined algorithm for the recognition of radiographs is proposed, which uses simultaneous two neural network models, based on Xception and DenseNet169. The method allows to generalize the knowledge of different medical experts and increases the accuracy of bone age prediction in general.


2016 ◽  
Vol 19 (2) ◽  
pp. 208-215 ◽  
Author(s):  
Heike Hoyer-Kuhn ◽  
Kai Knoop ◽  
Oliver Semler ◽  
Kathrin Kuhr ◽  
Martin Hellmich ◽  
...  
Keyword(s):  
Bone Age ◽  
X Rays ◽  

1974 ◽  
Vol 39 (3) ◽  
pp. 1127-1131 ◽  
Author(s):  
Leon Oettinger ◽  
Lawrence V. Majovski ◽  
George A. Limbeck ◽  
Ronald Gauch

53 children diagnosed as having minimal brain dysfunction by the criteria of Clements had X-rays of their left wrist and hand for the determination of bone age. All X-rays were read independently by three physicians skilled in radiology. The films were read blind, that is, sex and case numbers but not age were available. The degree of inter-rater reliability was very high ( r = 0.87). Bone age for the minimal brain dysfunction group was significantly retarded ( p < 0.01) compared with the standard group's norms. Bone ages of more than 2 SD below the mean occurred in 10 children, while only one child showed a bone age of more than 2 SD above the mean. Two-thirds of the children in the minimal brain dysfunction group fell below the mean of the standard norms. No correlation was found between bone age and thyroid level. These findings suggest that children diagnosed as having minimal brain dysfunction may be physiologically retarded in their bone age, although marked individual variations remain. The concept of physiological immaturity should be considered by professionals in the education and social planning for the child with minimal brain dysfunction.


ACTA IMEKO ◽  
2021 ◽  
Vol 10 (1) ◽  
pp. 32
Author(s):  
Laura Guidorzi ◽  
Fulvio Fantino ◽  
Elisabetta Durisi ◽  
Marco Ferrero ◽  
Alessandro Re ◽  
...  

Classified as an absolute dating method, thermoluminescence (TL) is a well-established radiation-based technique for the age determination and authentication of ceramic materials. Specifically, this method allows the determination of the time elapsed since kiln firing (or later fire events) by evaluating the luminescent emission of ceramics under heating at high temperatures. This paper provides a comprehensive presentation of the TL laboratory developed over the last decade at the Physics Department of the University of Torino. The laboratory was set up in collaboration with TecnArt S.r.l. and is also currently operating within the cultural heritage network of the National Institute of Nuclear Physics (INFN-CHNet). More than 10 years of experience in the field has resulted in improvements in procedures, with the development of customised alpha- and beta-irradiation systems and the optimisation of sampling approaches and chemical pre-treatment. Thanks to TecnArt S.r.l., the laboratory has been employed for dating and authenticating hundreds of archaeological sites and artworks, some of which are discussed in this work and compared, when possible, with radiocarbon dating.


2020 ◽  
Vol 16 (4) ◽  
pp. 641-648
Author(s):  
Ronja Estévez Dimitrov ◽  
Jens Amendt ◽  
Florian Rothweiler ◽  
Richard Zehner

AbstractDetermination of a minimal postmortem interval via age estimation of necrophagous diptera has been restricted to the juvenile stages and the time until emergence of the adult fly, i.e. up until 2–6 weeks depending on species and temperature. Age estimation of adult flies could extend this period by adding the age of the fly to the time needed for complete development. In this context pteridines are promising metabolites, as they accumulate in the eyes of flies with increasing age. We studied adults of the blow fly Lucilia sericata at constant temperatures of 16 °C and 25 °C up to an age of 25 days and estimated their pteridine levels by fluorescence spectroscopy. Age was given in accumulated degree days (ADD) across temperatures. Additionally, a mock case was set up to test the applicability of the method. Pteridine increases logarithmically with increasing ADD, but after 70–80 ADD the increase slows down and the curve approaches a maximum. Sex had a significant impact (p < 4.09 × 10−6) on pteridine fluorescence level, while body-size and head-width did not. The mock case demonstrated that a slight overestimation of the real age (in ADD) only occurred in two out of 30 samples. Age determination of L. sericata on the basis of pteridine levels seems to be limited to an age of about 70 ADD, but depending on the ambient temperature this could cover an extra amount of time of about 5–7 days after completion of the metamorphosis.


2009 ◽  
Vol 94 (12) ◽  
pp. 4868-4874 ◽  
Author(s):  
Hans Henrik Thodberg ◽  
Oskar G. Jenni ◽  
Jon Caflisch ◽  
Michael B. Ranke ◽  
David D. Martin

Context: Adult height prediction is a common procedure in pediatric endocrinology, but it is associated with a considerable variability and bias from the bone age rating. Objective: A new method for adult height prediction is presented, based on automated bone age determination. Method: The method predicts the fraction of height left to grow from age and BoneXpert bone age. This is refined by drawing the prediction toward the population mean, or alternatively toward the height predicted from the parents’ heights. Boys’ body mass index and girls’ height at menarche can be included optionally as predictors. Participants: A total of 231 normal children from the First Zurich Longitudinal Study (1ZLS) were followed from age 5 until cessation of growth with annual x-rays of the left hand. A total of 198 normal children from the Third Zurich Longitudinal Study were used for validation. Results: The root mean square error of adult height prediction (Tanner-Whitehouse 3 method in parentheses considered as standard for accuracy) on the 1ZLS was 3.3 cm (3.5 cm) for boys aged 10–15 yr and 2.7 cm (3.1 cm; P &lt; 0.005 for difference to Tanner-Whitehouse 3) for girls aged 8–13 yr. High body mass index before puberty negatively affected adult height of boys, independent of bone age. Conclusions: With the new method, adult height prediction has become objective because the dependence on manual bone age rating is eliminated. The method is well-suited to analyze large studies and provide a consistent body of evidence regarding the relation between maturation, body mass, and growth across populations, conditions, and ethnicities.


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