scholarly journals No Association of Leptin Receptor Gene Gln223Arg Polymorphism with Capillary Glucose Levels: A Preliminary Population Base Cross-Sectional Study

ISRN Genetics ◽  
2013 ◽  
Vol 2013 ◽  
pp. 1-7
Author(s):  
Geórgia das Graças Pena ◽  
Andre Luiz Sena Guimarães ◽  
Rosângela Ramos Veloso ◽  
Tatiana Carvalho Reis ◽  
João Felício Rodrigues Neto ◽  
...  
Keyword(s):  
Leptin Receptor ◽  
Receptor Gene ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Parental History ◽  
Glucose Levels ◽  
Capillary Glucose ◽  
Gln223arg Polymorphism ◽  
History Of Obesity

The leptin receptor gene has been reported to associate with insulin and glucose metabolism and adiposity in different study settings and various populations. Therefore, the aim of the study was to investigate the associations of the leptin receptor gene Gln223Arg polymorphism (LEPR Gln223Arg) with high capillary glucose levels. Cross-sectional study with probabilistic sample was carried out in individuals aged ≥18 years in an urban area of Montes Claros, MG, Brazil. The capillary glucose was considered high when ≥140 mg/dL. The genotypes of LEPR Gln223Arg distribution were as the following: 10.43% GG (n=49), 46.81% AG (n=220), and 42.77% AA (n=201), and there were no prevalence differences between genders, (P=0.57). Multivariate-adjusted models showed that there is no association between the polymorphism LEPR Gln223Arg and capillary high levels of glucose even when adjusted for age, sex, smoking, schooling, and parental history of obesity. In conclusion, no association between the polymorphism LEPR Gln223Arg and elevated blood glucose levels was detected.

scholarly journals Leptin Receptor Gene Gln223Arg Polymorphism Is Not Associated with Hypertension: A Preliminary Population-Based Cross-Sectional Study

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Geórgia das Graças Pena ◽  
Andre L. S. Guimarães ◽  
Rosângela R. Veloso ◽  
Tatiana C. Reis ◽  
Crizian S. Gomes ◽  
...  
Keyword(s):  
Leptin Receptor ◽  
Receptor Gene ◽  
Rflp Analysis ◽  
Population Based ◽  
Cross Sectional Study ◽  
High Morbidity ◽  
Sectional Study ◽  
Cross Sectional ◽  
History Of ◽  
Gln223arg Polymorphism

Hypertension is responsible for high morbidity and mortality as one of the most important cardiometabolic risk factors. The aim of the study was to investigate whether the Gln223Arg in the leptin receptor (LEPR) influences the prevalence of hypertension. A cross-sectional study was carried out in individuals aged ≥ 18 years. Polymorphism identification was performed using PCR-RFLP analysis. Participants with blood pressure ≥ 140/90 mmHg or medication use were considered hypertensive. Frequencies, means, cross-tabulations, and multivariate models were produced to study differences in hypertension prevalence by genotypes. The study includes 470 participants. The frequency of GG polymorphism variant was 10.43%, 46.81% AG, and 42.77% AA. The distribution of hypertension frequency by LEPR genotypes was the following: AA 43.8%, AG 40.4%, and GG 40.8%; there were no significant differences between groups. Comparative analysis which used multivariate Poisson regression adjusted by many potential confounders (age, sex, schooling, smoking, alcohol intake, obesity, and family history of parental obesity) did not modify this result. In this large sample of population-based study, the association of the LEPR Gln223Arg gene polymorphism with hypertension was not observed.

scholarly journals Association between maternal glucose levels during pregnancy and gestational diabetes mellitus: an analytical cross-sectional study

2015 ◽  
Vol 7 (1) ◽  
Author(s):  
Gisele Seabra ◽  
Cláudia Saunders ◽  
Patrícia de Carvalho Padilha ◽  
Lenita Zajdenverg ◽  
Letícia Barbosa Gabriel da Silva ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Glucose Levels ◽  
Maternal Glucose Levels ◽  
Maternal Glucose

scholarly journals Neck Circumference as an Anthropometric Indicator of Central Obesity in Patients with Prediabetes: A Cross-Sectional Study

2019 ◽  
Vol 2019 ◽  
pp. 1-8 ◽  
Author(s):  
Thunyarat Anothaisintawee ◽  
Nakarin Sansanayudh ◽  
Sangsulee Thamakaison ◽  
Dumrongrat Lertrattananon ◽  
Ammarin Thakkinstian
Keyword(s):  
Waist Circumference ◽  
Central Obesity ◽  
Cross Sectional Study ◽  
Neck Circumference ◽  
Youden Index ◽  
Sectional Study ◽  
Roc Curve Analysis ◽  
Cross Sectional ◽  
Pairwise Correlation ◽  
Glucose Levels

Measurement of waist circumference has substantial variability and some limitations, while neck circumference is a simple and reliable anthropometric measure. This study aimed to assess the association between neck circumference and waist circumference and to identify the best cutoff of neck circumference that could predict central obesity in prediabetic patients. This cross-sectional study included adult patients with prediabetes, defined as having fasting plasma glucose levels ranging from 100 to 125 mg/dL or HbA1c ranging from 5.7 to 6.49%, who visited the outpatient clinic of Family Medicine Department, Ramathibodi Hospital, Thailand, during October 2014 and March 2016. Neck circumference was measured from the level just below the laryngeal prominence perpendicular to the long axis of the neck. Central obesity was defined as having waist circumference measurements greater than 90 and 80 cm for males and females, respectively. The correlation between neck circumference and waist circumference was explored by applying pairwise correlation coefficient. Receiver operating characteristic (ROC) curve analysis was performed and Youden index equal to “sensitivity – (1-specificity)” was calculated. Neck circumference that yielded the maximum Youden index was determined as the optimal cutoff point for prediction of central obesity. There were 1,534 patients eligible for this study. After adjusting for covariables, neck circumference was found to be significantly associated with waist circumference in both females and males, with β-coefficients of 1.01 (95% CI: 0.83, 1.20) and 0.65 (95% CI: 0.46, 0.85), respectively. After applying the ROC analysis, neck circumferences ≥ 32 cm in females and ≥ 38 cm in males were determined as the best cutoff values to predict central obesity. Neck circumference is strongly correlated with waist circumference in prediabetics and should be considered as an alternative to the waist circumference measurement in screening for central obesity.

scholarly journals Does Good Aerobic Capacity Attenuate the Effects of Aging on Cardiovascular Risk Factors? Results from a Cross-Sectional Study in a Latino Population

2017 ◽  
Vol 2017 ◽  
pp. 1-7 ◽  
Author(s):  
Giovanna Valentino ◽  
Mónica Acevedo ◽  
Lorena Orellana ◽  
María José Bustamante ◽  
Verónica Kramer ◽  
...  
Keyword(s):  
Aerobic Capacity ◽  
Stress Test ◽  
Age Groups ◽  
Logistic Models ◽  
Exercise Stress Test ◽  
Cross Sectional Study ◽  
Exercise Stress ◽  
Sectional Study ◽  
Cross Sectional ◽  
Glucose Levels

Background. High aerobic capacity is associated with low cardiovascular (CV) risk. The aim of this study was to determine the CV RF burden in subjects with aerobic capacity ≥10 METs and compare it with those having <10 METs.Methods. Cross-sectional study in 2646 subjects (mean age 48 ± 12 years). Demographics, medical history, physical activity, cardiovascular RFs, fasting lipids and blood glucose levels, blood pressure, and anthropometric measurements were collected. Aerobic capacity was determined by exercise stress test. The ACC/AHA 2013 pooled cohort equation was used to calculate CV risk. Logistic models were built to determine the probability of having ≥2 RFs versus 0‐1 RF, by age and sex, according to aerobic capacity.Results. 15% of subjects had aerobiccapacity<10METs. The ACC/AHA scores were 15% in men and 6% in women with <10 METs and 5% and 2%, respectively, in those with ≥10 METs. The probability of having ≥2 RFs increased with age in both groups; however, it was significantly higher in subjects with <10 METs (odds ratio [OR]: 2.54; 95% CI: 1.92–3.35).Conclusions.Aerobic capacity≥10METs is associated with a better CV RF profile and lower CV risk score in all age groups, regardless of gender.

scholarly journals Hyperglycemia in pediatric head trauma patients: a cross-sectional study

2009 ◽  
Vol 67 (3b) ◽  
pp. 804-806 ◽  
Author(s):  
José Roberto Tude Melo ◽  
Rodolfo Casimiro Reis ◽  
Laudenor Pereira Lemos-Júnior ◽  
Henrique Miguel Santos Coelho ◽  
Carlos Eduardo Romeu de Almeida ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Head Trauma ◽  
Cross Sectional Study ◽  
Cranial Computed Tomography ◽  
Trauma Patients ◽  
Severe Head Trauma ◽  
Sectional Study ◽  
Cross Sectional ◽  
Glucose Levels ◽  
Computed Tomography Scans

OBJECTIVE: To verify the prevalence of acute hyperglycemia in children with head trauma stratified by the Glasgow coma scale (GCS). METHOD: A prospective cross-sectional study carried out with information from medical records of pediatric patients presenting with head injury in the emergency room of a referral emergency hospital during a one year period. We considered the cut-off value of 150 mg/dL to define hyperglycemia. RESULTS: A total of 340 children were included and 60 (17.6%) had admission hyperglycemia. Hyperglycemia was present in 9% of mild head trauma cases; 30.4% of those with moderate head trauma and 49% of severe head trauma. We observed that among children with higher blood glucose levels, 85% had abnormal findings on cranial computed tomography scans. CONCLUSION: Hyperglycemia was more prevalent in patients with severe head trauma (GCS <8), regardless if they had or not multiple traumas and in children with abnormal findings on head computed tomography scans.

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