scholarly journals Leptin Receptor Gene Gln223Arg Polymorphism Is Not Associated with Hypertension: A Preliminary Population-Based Cross-Sectional Study

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Geórgia das Graças Pena ◽  
Andre L. S. Guimarães ◽  
Rosângela R. Veloso ◽  
Tatiana C. Reis ◽  
Crizian S. Gomes ◽  
...  
Keyword(s):  
Leptin Receptor ◽  
Receptor Gene ◽  
Rflp Analysis ◽  
Population Based ◽  
Cross Sectional Study ◽  
High Morbidity ◽  
Sectional Study ◽  
Cross Sectional ◽  
History Of ◽  
Gln223arg Polymorphism

Hypertension is responsible for high morbidity and mortality as one of the most important cardiometabolic risk factors. The aim of the study was to investigate whether the Gln223Arg in the leptin receptor (LEPR) influences the prevalence of hypertension. A cross-sectional study was carried out in individuals aged ≥ 18 years. Polymorphism identification was performed using PCR-RFLP analysis. Participants with blood pressure ≥ 140/90 mmHg or medication use were considered hypertensive. Frequencies, means, cross-tabulations, and multivariate models were produced to study differences in hypertension prevalence by genotypes. The study includes 470 participants. The frequency of GG polymorphism variant was 10.43%, 46.81% AG, and 42.77% AA. The distribution of hypertension frequency by LEPR genotypes was the following: AA 43.8%, AG 40.4%, and GG 40.8%; there were no significant differences between groups. Comparative analysis which used multivariate Poisson regression adjusted by many potential confounders (age, sex, schooling, smoking, alcohol intake, obesity, and family history of parental obesity) did not modify this result. In this large sample of population-based study, the association of the LEPR Gln223Arg gene polymorphism with hypertension was not observed.

scholarly journals No Association of Leptin Receptor Gene Gln223Arg Polymorphism with Capillary Glucose Levels: A Preliminary Population Base Cross-Sectional Study

ISRN Genetics ◽  
2013 ◽  
Vol 2013 ◽  
pp. 1-7
Author(s):  
Geórgia das Graças Pena ◽  
Andre Luiz Sena Guimarães ◽  
Rosângela Ramos Veloso ◽  
Tatiana Carvalho Reis ◽  
João Felício Rodrigues Neto ◽  
...  
Keyword(s):  
Leptin Receptor ◽  
Receptor Gene ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Parental History ◽  
Glucose Levels ◽  
Capillary Glucose ◽  
Gln223arg Polymorphism ◽  
History Of Obesity

The leptin receptor gene has been reported to associate with insulin and glucose metabolism and adiposity in different study settings and various populations. Therefore, the aim of the study was to investigate the associations of the leptin receptor gene Gln223Arg polymorphism (LEPR Gln223Arg) with high capillary glucose levels. Cross-sectional study with probabilistic sample was carried out in individuals aged ≥18 years in an urban area of Montes Claros, MG, Brazil. The capillary glucose was considered high when ≥140 mg/dL. The genotypes of LEPR Gln223Arg distribution were as the following: 10.43% GG (n=49), 46.81% AG (n=220), and 42.77% AA (n=201), and there were no prevalence differences between genders, (P=0.57). Multivariate-adjusted models showed that there is no association between the polymorphism LEPR Gln223Arg and capillary high levels of glucose even when adjusted for age, sex, smoking, schooling, and parental history of obesity. In conclusion, no association between the polymorphism LEPR Gln223Arg and elevated blood glucose levels was detected.

scholarly journals Are normoglycaemic individuals at risk of depression? The depression-dysglycaemic phenotype from a European population-based cross-sectional study

2019 ◽  
Author(s):  
Sarah Cuschieri ◽  
Julian Mamo
Keyword(s):  
Communicable Disease ◽  
Population Level ◽  
Female Gender ◽  
Educational Status ◽  
Population Based ◽  
Cross Sectional Study ◽  
Health Concern ◽  
Sectional Study ◽  
Cross Sectional ◽  
History Of

Abstract Background Depression is an ever more common chronic non communicable disease and its control constitutes a growing public health concern given its links with a number of co-morbidities, including diabetes mellitus. The study aimed to estimate the prevalence of depression at a population level across groups of different glycaemic status, whilst establishing its socioeconomic phenotypic characteristics.Methods A nationally representative cross-sectional study was conducted in Malta between 2014 and 2016. Participants were categorized into different sub-populations according to their glycaemic status. Depression prevalence rates and socio-economic characteristics for each sub-population were established. Multiple regression analysis was performed to identify links with depression.Results Depression was prevalent in 17.15% (CI 95%: 16.01 – 18.36) with a female predominance. The normoglycaemic sub-population had the highest depression rates. However, persons with known diabetes had a higher probability of having a history of depression (OR:2.36 CI 95%:1.12 – 4.96), as well as with being of the female gender, having lower educational status, having a history of smoking tobacco and having established cardiovascular disease.Conclusions Depression was highly prevalent among the normoglycaemic population especially as age progress. Physicians in primary care should implement a depression screening tool as part of their routine health check-ups, with special attention to those with cardiovascular co-morbidities and any signs of psycho-socio-economic burden.

The association of acne and menstrual symptoms among young women (18–25 years) in Egypt: a population-based cross-sectional study

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Ahmed Arafa ◽  
Alshimaa Mostafa ◽  
Yasser Khamis
Keyword(s):  
Young Women ◽  
Population Based ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Multi Stage ◽  
Menstrual Symptoms ◽  
History Of ◽  
The Relationship ◽  
Age Of Menarche

AbstractBackgroundAcne and menstrual symptoms are highly prevalent among young women. Since both acne and menstrual symptoms have similar hormonal pathogenesis, it is highly suggested that the two conditions are associated. Herein, we conducted this study to assess the relationship between acne and menstrual symptoms among young women.Subjects and methodsIn this population-based cross-sectional study, a multi-stage random sampling approach was used to include 3065 young women (18–25 years) from Egypt. Women were interviewed for their socio-demographic characteristics, gynecological history, premenstrual and menstrual symptoms, and history of acne and perimenstrual acne flare during the past 6 months.ResultsThe mean age of women was 21.5 ± 2.2 and their age of menarche was 13.1 ± 1.5 years. During the previous 6 months, 44.8% of participants had acne. After adjusting for socio-demographic and gynecological characteristics, acne was associated with most menstrual symptoms with odds ratios (ORs) and 95% confidence intervals (CIs) as follows: [premenstrual symptoms: 1.23 (1.05–1.44) for irritation or nervousness, 1.45 (1.24–1.68) for fatigue, 1.37 (1.15–1.62) for breast tenderness, 1.48 (1.21–1.80) for abdominal bloating, and 1.36 (1.11–1.66) for nausea or vomiting], [menstrual symptoms: 1.63 (1.19–2.23) for dysmenorrhea and 1.24 (1.06–1.45) for dysmenorrhea requiring drugs], and [symptoms severity: 1.44 (1.24–1.68) for missing events and 1.38 (1.16–1.64) for medical consultation]. Of acne patients, 56.7% reported perimenstrual acne flare: 58.5% before menses, 35% during menses, and 6.5% after menses.ConclusionThis study supports the concept that acne is associated with menstrual symptoms. Physicians should consider screening for menstrual symptoms among young women with acne.

scholarly journals Population-based cohort of 500 patients with Gaucher disease in Israel

BMJ Open ◽  
2019 ◽  
Vol 9 (1) ◽  
pp. e024251 ◽  
Author(s):  
Dena H Jaffe ◽  
Natalie Flaks-Manov ◽  
Arriel Benis ◽  
Hagit Gabay ◽  
Marco DiBonaventura ◽  
...  
Keyword(s):  
Gaucher Disease ◽  
Population Based ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Enzyme Replacement ◽  
History Of ◽  
Study Population ◽  
Comorbidity Index ◽  
History Of Cancer

ObjectiveTo characterise a population-based cohort of patients with Gaucher disease (GD) in Israel relative to the general population and describe sociodemographic and clinical differences by disease severity (ie, enzyme replacement therapy [ERT] use).DesignA cross-sectional study was conducted.SettingData from the Clalit Health Services electronic health record (EHR) database were used.ParticipantsThe study population included all patients in the Clalit EHR database identified as having GD as of 30 June 2014.ResultsA total of 500 patients with GD were identified and assessed. The majority were ≥18 years of age (90.6%), female (54.0%), Jewish (93.6%) and 34.8% had high socioeconomic status, compared with 19.0% in the general Clalit population. Over half of patients with GD with available data (51.0%) were overweight/obese and 63.5% had a Charlson Comorbidity Index ≥1, compared with 46.6% and 30.4%, respectively, in the general Clalit population. The majority of patients with GD had a history of anaemia (69.6%) or thrombocytopaenia (62.0%), 40.4% had a history of bone events and 22.2% had a history of cancer. Overall, 41.2% had received ERT.ConclusionsEstablishing a population-based cohort of patients with GD is essential to understanding disease progression and management. In this study, we highlight the need for physicians to monitor patients with GD regardless of their ERT status.

scholarly journals Determination of Seroprevalence and Risk Factors of Crimean–Congo Haemorrhagic Fever (CCHF) in the Endemic Region in Turkey: A Population-Based Cross-Sectional Study

2021 ◽  
Vol 2021 ◽  
pp. 1-10
Author(s):  
Rıza Çıtıl ◽  
Mücahit Eğri ◽  
Yalçın Önder ◽  
Fazilet Duygu ◽  
Yunus Emre Bulut ◽  
...  
Keyword(s):  
Risk Factors ◽  
Low Income ◽  
Animal Husbandry ◽  
Population Based ◽  
Cross Sectional Study ◽  
Age Group ◽  
Sectional Study ◽  
Endemic Region ◽  
Cross Sectional ◽  
History Of

Objectives. Turkey is one of the countries that has the most cases of CCHF in recent years among the endemic countries. The disease also poses an important health threat with high mortality rate. The aim of the study was to determine the seroprevalence and risk factors of CCHF in adults aged ≥20 years in Tokat in the endemic region, Turkey. Methods. In this population-based cross-sectional study, a total of 85 Family Medicine Units (FMUs), from over 170 in Tokat, were randomly selected using 50% sampling. The sample size was determined among the subjects aged ≥20 who registered with the FMUs, due to gender, age group, and the urban/rural population size of Tokat using the stratified cluster sampling method. Subjects were invited to the FMUs. A questionnaire was performed face to face. The blood samples were taken, and anti-CCHFV IgG antibodies were measured with ELISA method. Results. 1272 (54.9%) out of 2319 participants were female, and the mean age was 47.3 ± 15.3. Anti-CCHFV IgG seropositivity was 5.6% (n = 130). Seropositivity rates in terms of adjusted odds ratios (AOR) were higher 2.53 times (95% CI: 1.57–4.08; p = 0.001 ) in males; 4.05 (95% CI: 2.14–7.65; p < 0.001 ) in age group ≥65; 0.33 (95% CI: 0.14–0.76; p < 0.001 ) in graduates of high school and above; 0.71 (95%CI: 0.33–1.52; p < 0.001 ) in ones with good income; 1.84 (95%CI: 1.18–2.86; p < 0.001 ) in farmers; 1.64 (95% CI: 1.04–2.27; p < 0.001 ) in people dealing with animal husbandry; and 1.02 (95% CI: 1.03–2.29; p < 0.001 ) in those with history of tick contact. Conclusions. CCHF seroprevalence is still a common public health problem in Tokat, Turkey. Male gender, advanced age group, low-educated, low-income, farmers, animal husbandry, and history of tick contact were found to be risk factors for CCHF. The importance of this kind of community-based studies to identify the seroprevalence in regional and national level increases even more.

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