scholarly journals A Single Nucleotide Polymorphism of Follicle-Stimulating Hormone Receptor Gene in Turkish Women with PCOS: A Cross-Sectional Study

2017 ◽  
Vol 8 (2) ◽  
Author(s):  
Ümit Naykı ◽  
Altuğ Koç ◽  
Cenk Naykı ◽  
Özge Özer Kaya ◽  
Mehmet Kulhan ◽  
...  
Keyword(s):  
Single Nucleotide Polymorphism ◽  
Receptor Gene ◽  
Follicle Stimulating Hormone ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Turkish Women ◽  
Nucleotide Polymorphism ◽  
Cross Sectional ◽  
Single Nucleotide ◽  
Hormone Receptor Gene

The FTO rs17817449 Polymorphism is Not Associated With Sedentary Time, Physical Activity, or Cardiorespiratory Fitness: Findings From the GENADIO Cross-Sectional Study

2021 ◽  
pp. 1-6
Author(s):  
Miquel Martorell ◽  
Lorena Mardones ◽  
Fanny Petermann-Rocha ◽  
Maria Adela Martinez-Sanguinetti ◽  
Ana Maria Leiva-Ordoñez ◽  
...  
Keyword(s):  
Physical Activity ◽  
Single Nucleotide Polymorphism ◽  
Cardiorespiratory Fitness ◽  
Sedentary Time ◽  
Risk Allele ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Nucleotide Polymorphism ◽  
Cross Sectional ◽  
Single Nucleotide

Background: Genetic variants within the FTO gene have been associated with increased adiposity and metabolic markers; however, there is limited evidence regarding the association of FTO gene variants with physical activity-related variables. The authors aimed to investigate the association of the rs17817449 single-nucleotide polymorphism of FTO with physical activity, sedentary time, and cardiorespiratory fitness in Chilean adults. Methods: A total of 409 participants from the GENADIO study were included and genotyped for the rs17817449 single-nucleotide polymorphism of FTO in this cross-sectional study. Physical activity and sedentary time were measured with ActiGraph accelerometers. Cardiorespiratory fitness was assessed using the Chester step test. The associations were assessed by using multivariate regression analyses. Results: No associations were found for FTO variant with physical activity levels and cardiorespiratory fitness. The risk allele (G) of the FTO was found to be associated with sedentary time in the minimally adjusted model (β = 19.7 min/d; 95% confidence interval, 4.0 to 35.5, per each copy of the risk allele; P = .006), but the association was no longer significant when body mass index was included as a confounder (P = .211). Conclusion: The rs17817449 single-nucleotide polymorphism of the FTO gene was not associated with the level of physical activity, cardiorespiratory fitness, and sedentary behaviors in Chilean adults.

scholarly journals APPLICATION OF THE REAL – TIME PCR FOR THE DETECTION OF CYP2C19*2 SINGLE NUCLEOTIDE POLYMORPHISM IN PATIENS WITH GASTRITIS AT TRA VINH GENERAL HOSPITAL

2018 ◽  
Vol 1 (32) ◽  
pp. 39-43
Author(s):  
Duy Anh Ngo ◽  
Trung Thien Tran ◽  
Anh Tuan Nguyen ◽  
Thanh Tien Nguyen
Keyword(s):  
New York ◽  
General Hospital ◽  
Cross Sectional Study ◽  
Nucleotide Polymorphisms ◽  
Sectional Study ◽  
Nucleotide Polymorphism ◽  
Cross Sectional ◽  
Single Nucleotide ◽  
Taqman Probes ◽  
Pcr Method

The aim of this study is to identify CYP2C19*2 single nucleotide polymorphisms in patients with gastritis at TraVinh General Hospital. A cross-sectional study was conducted in 280 endoscopic gastric biopsy samples of patients with gastritis at TraVinh General Hospital. CYP2C19*2 genotypes were determined by realtime PCR method using TaqMan probes. Data were stored and analyzed by IBM SPSS Statistic (version 20.0; Armonk, New York, USA) and Excel 2010. The prevallelece of GG, AG and AA genotypes were 51.8, 39.6 and 8.6% correspondingly. The ratio of allele G and A were 0.716 and 0.284 respectively. The correlation of CYP2C19*2 polymorphisms with age (p=0.891), gender (p=0.652) was not significantly distinguished

Genetic Association of FTO rs9939609 Polymorphism with Hypertension in Pakistani Population

2021 ◽  
Vol 15 (11) ◽  
pp. 2985-2988
Author(s):  
Sobia Tabassum ◽  
Sadaf Mushtaq ◽  
M. Naveed Anwar ◽  
H. Achakzai ◽  
Naseer Ahmed ◽  
...  
Keyword(s):  
Single Nucleotide Polymorphism ◽  
Medical Condition ◽  
Cross Sectional Study ◽  
Nucleotide Polymorphism ◽  
Cross Sectional ◽  
Single Nucleotide ◽  
Pakistani Population ◽  
Significant Difference ◽  
Mutation System ◽  
Fto Rs9939609

Background: Hypertension is a medical condition that often occurs parallel to diabetes and obesity. Previously, the role of fat mass and obesity associated (FTO) gene rs9939609 polymorphism (c.46-23525T>A) with obesity has been reported while prevalence and etiological differences exist among different regions and ethnic groups. Aim: To investigate the association of FTO rs9939609 SNP with hypertension in Pakistani population. Study design: Cross-sectional study. Place and duration of study: Institute of Biomedical and Genetic Engineering (IBGE), Islamabad, Pakistan from 1st January 2019 to 31st December 2020. Methodology: One hundred and ten diagnosed hypertension patients along with 128 healthy volunteers were selected randomly. The single nucleotide polymorphism was analyzed using Amplified Refractory Mutation System-Polymerase Chain Reaction. Results: In hypertension patients, females were found to be relatively more affected and average blood pressure lies in stage 1. However, we found no significant difference in genotypic frequencies of FTO rs9939609; TT (22.6%), AA (39.6%) and AT (37.8%) and TT (17.18%), AA (39.06%), and AT (43.75%) among HT and controls, respectively. The p and OR values for risk type genotype (AA) are 0.4697 and 0.7700 (95% CI=0.3788-1.565), respectively. Subsequently, the high percentage (60.0 %) of risk genotype (AA) was found in obese-body mass index in hypertension patients. Conclusion: FTO rs9939609 single nucleotide polymorphism may not be a genetic risk factor associated with onset of hypertension directly and is linked with obesity in Pakistani patients. Keywords: FTO, Hypertension, Obesity, Pakistani patients, rs9939609

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