scholarly journals Bipolar Disorder and Cardiovascular Risk in Rural versus Urban Populations in Colombia: A Comparative Clinical and Epidemiological Evaluation

2021 ◽  
Vol 87 (1) ◽  
Author(s):  
Juan Pablo Forero ◽  
Alexander Ferrera ◽  
Jose Daniel Castaño ◽  
Sergio Ardila ◽  
Tanya Mesa ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Cardiovascular Risk ◽  
Urban Populations ◽  
Epidemiological Evaluation

Thirty-year cardiovascular risk score in patients with newly diagnosed bipolar disorder and their unaffected first-degree relatives

2018 ◽  
Vol 53 (7) ◽  
pp. 651-662 ◽  
Author(s):  
Klara Coello ◽  
Hanne L Kjærstad ◽  
Sharleny Stanislaus ◽  
Sigurd Melbye ◽  
Maria Faurholt-Jepsen ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Bipolar Disorder ◽  
Cardiovascular Risk ◽  
Risk Score ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
Newly Diagnosed ◽  
Healthy Individuals ◽  
First Degree Relatives ◽  
Age And Sex

Objectives: Bipolar disorder is associated with a decreased life expectancy of 8–12 years. Cardiovascular disease is the leading cause of excess mortality. For the first time, we investigated the Framingham 30-year risk score of cardiovascular disease in patients with newly diagnosed/first-episode bipolar disorder, their unaffected first-degree relatives and healthy individuals. Methods: In a cross-sectional study, we compared the Framingham 30-year risk score of cardiovascular disease in 221 patients with newly diagnosed/first-episode bipolar disorder, 50 of their unaffected first-degree relatives and 119 healthy age- and sex-matched individuals with no personal or first-degree family history of affective disorder. Among patients with bipolar disorder, we further investigated medication- and illness-related variables associated with cardiovascular risk. Results: The 30-year risk of cardiovascular disease was 98.5% higher in patients with bipolar disorder ( p = 0.017) and 85.4% higher in unaffected first-degree relatives ( p = 0.042) compared with healthy individuals in models adjusted for age and sex. When categorizing participants in low cardiovascular risk without considering age and sex distribution among participants, 81% of patients were at low risk, versus 92% of unaffected relatives and 89% of healthy individuals. Of the patients 209 (94.6%) were diagnosed within the preceding 2 years. Smoking was more prevalent among patients with bipolar disorder (45.2%) and their unaffected first-degree relatives (20.4%) compared with healthy individuals (12.8%). Similarly, dyslipidemia was more common among patients with bipolar disorder compared with healthy individuals. Treatment with psychotropic medication with metabolic adverse effects was associated with higher 30-year cardiovascular disease risk score, whereas we did not find illness-related variables associated with cardiovascular risk among patients with bipolar disorder. Conclusion: We found an enhanced cardiovascular disease risk score in patients with newly diagnosed bipolar disorder and their unaffected first-degree relatives, which points to a need for specific primary preventive interventions against smoking and dyslipidemia in these populations.

Thirty-year cardiovascular risk in patients with newly diagnosed bipolar disorder and their healthy first-degree relatives

2019 ◽  
Vol 29 ◽  
pp. S347-S348
Author(s):  
K. Coello ◽  
H. Kjærstad ◽  
S. Stanislaus ◽  
S. Melbye ◽  
M. Fauerholt-Jepsen ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Cardiovascular Risk ◽  
Newly Diagnosed ◽  
First Degree Relatives

261 – Cardiovascular risk in patients with bipolar disorder under treatment

2008 ◽  
Vol 98 ◽  
pp. 141 ◽  
Author(s):  
M.P. Garcia-Portilla ◽  
P.A. Saiz ◽  
A. Benabarre ◽  
J. Bobes
Keyword(s):  
Bipolar Disorder ◽  
Cardiovascular Risk

Epidemiological evaluation of known and suspected cardiovascular risk factors in chronic renal impairment

2001 ◽  
Vol 38 (3) ◽  
pp. 537-546 ◽  
Author(s):  
Martin J. Landray ◽  
Jeetendra Thambyrajah ◽  
Fiona J. McGlynn ◽  
Heather J. Jones ◽  
Colin Baigent ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Renal Impairment ◽  
Cardiovascular Risk Factors ◽  
Chronic Renal Impairment ◽  
Epidemiological Evaluation

Cardiovascular Risk in a Spanish Population of Bipolar Disorder Patients: Results from the BIMET Study

2009 ◽  
Vol 24 (S1) ◽  
pp. 1-1
Author(s):  
J.M. Montes ◽  
E. Vieta ◽  
A. González-Pinto ◽  
J. Rejas-Gutiérrez ◽  
F. Mesa
Keyword(s):  
Bipolar Disorder ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Cardiovascular Risk ◽  
Cardiovascular Mortality ◽  
Hdl Cholesterol ◽  
Cardiovascular Death ◽  
Spanish Population ◽  
Type I ◽  
Schizophrenia Spectrum Disorders

Purpose:To estimate the 10-years coronary heart disease and cardiovascular mortality risks in a Spanish population of bipolar disorder (BD) patients.Methods:BIMET study is a 12-month, prospective, multicentre, naturalistic study which enrolled type I or II BD patients according to DSM-IV TR criteria. A fasting blood sample was drawn to evaluate glucose, total cholesterol, HDL cholesterol, LDL cholesterol and triglycerides. Weight, height, waist circumference at the umbilicus and blood pressure were also recorded. Framinghan and SCORE functions were used to calculate the 10-year risk for coronary hearth disease or cardiovascular death respectively.Results:A total of 320 and 417 patients, mean age 46.3 (13.0) years, were included for the Framingham and SCORE calculations respectively. The overall mean (standard deviation) risk for coronary heart disease was 7.3% (7.8) according to Framingham algorithm, with 6.3% of patients classified as having a high risk of coronary disease (Framingham higher than 10%). The mean overall risk for cardiovascular mortality was 1.2% (2.4) according to SCORE algorithm, with 6.5% of patients falling within the high cardiovascular mortality risk segment; SCORE higher than 5%. No statistically significant differences were observed between type I and II patients.Conclusion:This study reflects a substantial risk for cardiovascular events or mortality in a Spanish cohort of bipolar disorder patients. Results were comparable to those seen in subject with schizophrenia spectrum disorders. Therefore, an effort for controlling all cardiovascular risk factors in bipolar disorder patients should be carried out by clinicians and health decision makers.

scholarly journals Lifestyle-related cardiovascular risk factors in patients with bipolar disorder

2013 ◽  
Vol 17 (4) ◽  
pp. 28-33 ◽  
Author(s):  
Steve Brown ◽  
Rupa Ramesh ◽  
Stephanie Newson ◽  
Rosie Isaacs
Keyword(s):  
Risk Factors ◽  
Bipolar Disorder ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors

Risk of out-of-hospital cardiac arrest in patients with bipolar disorder or schizophrenia

Heart ◽  
2021 ◽  
pp. heartjnl-2020-318078
Author(s):  
Carlo Alberto Barcella ◽  
Grimur Mohr ◽  
Kristian Kragholm ◽  
Daniel Christensen ◽  
Thomas A Gerds ◽  
...  
Keyword(s):  
Risk Factors ◽  
Bipolar Disorder ◽  
Cardiac Arrest ◽  
Cardiovascular Risk ◽  
General Population ◽  
Cardiovascular Risk Factors ◽  
Cardiac Disease ◽  
Cox Regression ◽  
Shockable Rhythm ◽  
Hospital Cardiac Arrest

ObjectivePatients with bipolar disorder and schizophrenia are at high cardiovascular risk; yet, the risk of out-of-hospital cardiac arrest (OHCA) compared with the general population remains scarcely investigated.MethodsWe conducted a nested case-control study using Cox regression to assess the association of bipolar disorder and schizophrenia with the HRs of OHCA of presumed cardiac cause (2001–2015). Reported are the HRs with 95% CIs overall and in subgroups defined by established cardiac disease, cardiovascular risk factors and psychotropic drugs.ResultsWe included 35 017 OHCA cases and 175 085 age-matched and sex-matched controls (median age 72 years and 66.9% male). Patients with bipolar disorder or schizophrenia had overall higher rates of OHCA compared with the general population: HR 2.74 (95% CI 2.41 to 3.13) and 4.49 (95% CI 4.00 to 5.10), respectively. The association persisted in patients with both cardiac disease and cardiovascular risk factors at baseline (bipolar disorder HR 2.14 (95% CI 1.72 to 2.66), schizophrenia 2.84 (95% CI 2.20 to 3.67)) and among patients without known risk factors (bipolar disorder HR 2.14 (95% CI 1.09 to 4.21), schizophrenia HR 5.16 (95% CI 3.17 to 8.39)). The results were confirmed in subanalyses only including OHCAs presenting with shockable rhythm or receiving an autopsy. Antipsychotics—but not antidepressants, lithium or antiepileptics (the last two only tested in bipolar disorder)—increased OHCA hazard compared with no use in both disorders.ConclusionsPatients with bipolar disorder or schizophrenia have a higher rate of OHCA compared with the general population. Cardiac disease, cardiovascular risk factors and antipsychotics represent important underlying mechanisms.

scholarly journals Homocysteine and other markers of cardiovascular risk during a manic episode in patients with bipolar disorder

2013 ◽  
Vol 35 (2) ◽  
pp. 157-160 ◽  
Author(s):  
Fábria Chiarani ◽  
Juliana Fernandes Tramontina ◽  
Keila Maria Ceresér ◽  
Maurício Kunz ◽  
Leonardo Paim ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Cardiovascular Risk ◽  
Manic Episode
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