Calcineurin Inhibitors: A Novel Approach to Canine Atopic Dermatitis

2005 ◽  
Vol 41 (2) ◽  
pp. 92-97 ◽  
Author(s):  
Rosanna Marsella
Keyword(s):  
Atopic Dermatitis ◽  
Adverse Effects ◽  
Mechanism Of Action ◽  
Broad Spectrum ◽  
Skin Diseases ◽  
Calcineurin Inhibitors ◽  
Relevant Information ◽  
Novel Approach ◽  
Allergic Skin ◽  
Traditional Therapies

The introduction of calcineurin inhibitors represents a major addition to the armamentarium of drugs available to veterinary clinicians for the management of allergic skin diseases. Both cyclosporine and tacrolimus have been proven to be well tolerated and effective for the treatment of atopic dermatitis in dogs. Although broad spectrum in their mechanism of action, they lack the major adverse effects of glucocorticoids and provide an appealing alternative to traditional therapies. The purposes of this article are to review clinically relevant information regarding these agents and to provide tips for maximizing the benefit obtained from these therapies.

scholarly journals ТHE EFFICIENCY AND SAFETY OF CALCINEURIN INHIBITORS (TACROLIMUS) IN ATOPIC DERMATITIS AND OTHER DERMATOLOGICAL DISEASES

2011 ◽  
Vol 8 (2) ◽  
pp. 89-95
Author(s):  
S A Ochelenko ◽  
K N Monakhov ◽  
S A Ochelenko ◽  
K N Monakhov
Keyword(s):  
Atopic Dermatitis ◽  
Adverse Effects ◽  
Alopecia Areata ◽  
Clinical Effect ◽  
High Efficiency ◽  
Skin Diseases ◽  
Calcineurin Inhibitors ◽  
Dermatological Diseases ◽  
Positive Effects ◽  
Topical Corticosteroids

The problems of clinical efficiency and safety of application of tacrolimus (Protopik) at various skin diseases are discussed in this review. High efficiency of this drug, allows to use it in treatment of different dermatosis. The clinical effect is comparable with topical corticosteroids, and the rate of adverse effects is lower. It is possible to use long applications of calcineurin inhibitors in patients with resistant forms of atopic dermatitis. Positive effects of application of tacrolimus in vitiligo, balanitis, alopecia areata etc. are described.

scholarly journals Itch in Atopic Dermatitis – What Is New?

2021 ◽  
Vol 8 ◽  
Author(s):  
Franz J. Legat
Keyword(s):  
Atopic Dermatitis ◽  
Intracellular Signaling ◽  
Sleep Disturbances ◽  
Skin Diseases ◽  
Immunosuppressive Agents ◽  
Calcineurin Inhibitors ◽  
Inflammatory Skin Diseases ◽  
New Era ◽  
Short And Long Term ◽  
Chronic Pruritus

Atopic dermatitis (AD) is among the most frequent inflammatory skin diseases in humans, affecting up to 20% of children and 10% of adults in higher income countries. Chronic pruritus is a disease-defining symptom of AD, representing the most burdensome symptom for patients. Severe chronic pruritus causes significant sleep disturbances and impaired quality of life, as well as increased anxiety, depression and suicidal behavior. Until recently, skin care, topical corticosteroids, and calcineurin-inhibitors were primarily used to treat mild to moderate AD, while phototherapy and immunosuppressive agents such as corticosteroids, cyclosporine, and methotrexate were used to treat patients with moderate to severe AD. The potential short- and long-term adverse events associated with these treatments or their insufficient therapeutic efficacy limited their use in controlling pruritus and eczema in AD patients over longer periods of time. As our understanding of AD pathophysiology has improved and new systemic and topical treatments have appeared on the market, targeting specific cytokines, receptors, or their intracellular signaling, a new era in atopic dermatitis and pruritus therapy has begun. This review highlights new developments in AD treatment, placing a specific focus on their anti-pruritic effects.

scholarly journals CLINICAL AND DIAGNOSTIC VALUE OF DETERMINATION OF NEOPTERIN IN ATOPIC DERMATITIS IN CHILDREN

2018 ◽  
Vol 25 (3) ◽  
pp. 24-27
Author(s):  
M. M. BEN ◽  
E. YU. YANCHEVSKAYA ◽  
O. A. MESNYANKINA
Keyword(s):  
Atopic Dermatitis ◽  
Skin Diseases ◽  
Secondary Infection ◽  
Clinical Manifestations ◽  
Diagnostic Value ◽  
Laboratory Method ◽  
Control Group ◽  
Allergic Skin ◽  
Monitoring And Forecasting

Aim. To improve the diagnosis of allergic skin diseases in childrenMaterials and methods. 135 children aged from 2 to 6 with atopic dermatitis were examined during exacerbation. They were on inpatient treatment in the skin and venereologic department of the Regional skin and venereologic dispensary and the Department of Allergology of the Regional children's clinical hospital. At the same time, 103 people (the main group) had uncomplicated course of the disease, 32 patients had complications of atopic dermatitis in the form of secondary infection. The control group consisted of 29 children aged 2 to 6. Neopterin in serum was determined by enzyme-linked immunosorbent analysis using test kits "Neopterin ELISA" (Germany). Statistical reliability of the obtained data was evaluated using The Student's test.Results. Atopic dermatitis in children, regardless of clinical manifestations, is accompanied by an increase in the content of neopterin in serum. The nature of the increase in the level of neopterin is determined by the duration of the disease, while its highest values are characteristic of the prolonged course of the process (over 4 years).Conclusion. The determination of neopterin in children with atopic dermatitis is a promising laboratory method for assessing the severity of dermatosis, monitoring and forecasting the further course of the process, as well as evaluating the effectiveness of therapeutic measures.

scholarly journals Features of pathogenesis of itch and anti0itch therapy in children with allergic dermatosis (literature review)

2021 ◽  
pp. 57-67
Author(s):  
O.M. Mochulska ◽  
Keyword(s):  
Skin Diseases ◽  
Environmental Control ◽  
Allergic Inflammation ◽  
Calcineurin Inhibitors ◽  
Stevens Johnson Syndrome ◽  
Individual Approach ◽  
Topical Calcineurin Inhibitors ◽  
Multi Stage ◽  
Johnson Syndrome ◽  
Allergic Skin

Allergic dermatoses are allergic skin diseases, the most common of which are: simple and allergic contact dermatitis, atopic dermatitis, various forms of eczema, acute and chronic allergic urticaria, Quincke's edema, toxicodermias, multiforme exudative erythema (Stevens–Johnson syndrome), acute epidermal necrolysis (Lyell's syndrome). The clinical course of all allergic dermatoses is accompanied by itch, although its severity varies depending on the nosology. An important focus of treatment of allergic dermatoses is to control of skin itch, as it is the leading symptom. According to the international program documents EAACI (European Academy of Allergy and Clinical Immunology), AAAAI (American Academy of Allergy, Asthma & Immunology), PRACТALL (Practical Allergology Consensus Report) in treatment of allergic dermatoses the leading place takes anti-itch therapy, which requires an individual approach and daily care of skin. Systemic anti-itch therapy includes using of the following drugs: antihistamines, glucocorticosteroids, membrane's stabilizators (kromons), leukotriene receptor antagonists, anti-IgE. External anti-itch therapy consists of local application of emollients, topical glucocorticosteroids, topical calcineurin inhibitors, topical anti-histamines, reparants and epithelializing medications. Purpose — to increase knowledge about features of etiopathogenetically-based anti-itch therapy of allergic dermatoses in children. Conclusions. Treatment of itch of allergic dermatoses is diverse, complex and multi-stage, requires an individual approach to each patient, and includes: environmental control to eliminate allergenic and non-allergenic factors, systemic and local pharmacotherapy, skin care. Modern anti-itch therapy of allergic dermatoses should be etiopathogenetic and affect on local and system mechanisms of allergic inflammation with itch, it should be differentiated according to the stage of the disease, the phase of inflammation and the severity of skin manifestations and to be based on the rational use of drugs. No conflict of interest was declared by the author. Key words: children, allergy, allergic dermatoses, itch, anti-itch therapy.

scholarly journals ALLERGIC SKIN DISEASES AND SPORT

2012 ◽  
Vol 9 (5) ◽  
pp. 17-25
Author(s):  
N V Shartanova ◽  
O G Elisyutina ◽  
E S Fedenko ◽  
N I Ilina
Keyword(s):  
Physical Activity ◽  
Atopic Dermatitis ◽  
Skin Diseases ◽  
Elite Athletes ◽  
Skin Reactions ◽  
Immunological Mechanisms ◽  
Allergic Skin

According to various authors up to 25% of athletes suffer from allergies. In this review, we are talking about allergodermatoses. Various immunological mechanisms are underlying of skin reactions in elite athletes. Interesting facts about anaphylaxis, associated with physical activity and consumption of some food as well as about contact and atopic dermatitis are presented.

The prevalence of dogs with lymphocyte proliferative responses to food allergens in canine allergic dermatitis

2013 ◽  
Vol 16 (4) ◽  
pp. 735-739 ◽  
Author(s):  
K. Kawano ◽  
K. Oumi ◽  
Y. Ashida ◽  
Y. Horiuchi ◽  
T. Mizuno
Keyword(s):  
Atopic Dermatitis ◽  
Positive Result ◽  
Diagnostic Test ◽  
Skin Disease ◽  
Skin Diseases ◽  
Elimination Diet ◽  
Test Results ◽  
Food Allergens ◽  
Ige Antibodies ◽  
Allergic Skin

Abstract The aim of the present study was to examine the correlation between the results of lymphocyte proliferative test (LPT) specific to food allergens and allergic skin diseases in dogs. Investigations were performed in 138 dogs with allergic skin diseases diagnosed in a private animal hospital. Of the 138 animals, 97 cases had positive reactions in LPT specific to food allergens. Of these 97 dogs, 67 animals were diagnosed with canine atopic dermatitis (CAD), but 30 dogs did not have IgE antibodies to environmental allergens. As 14 dogs out of 30 animals showed a positive result, 12 dogs underwent elimination diet trial based on the test results and all of them showed improvement in the pruritus score. Therefore, we conclude that LPT is an effective diagnostic test for allergic skin disease. Results of the lymphocyte test are useful in the identification of food allergens for the elimination diet trial

scholarly journals THE EFFICIENCY OF LEVOCETIRIZINE IN TREATMENT OF ALLERGIC SKIN DISEASES

2012 ◽  
Vol 9 (5) ◽  
pp. 69-75
Author(s):  
O G Elisyutina ◽  
E S Fedenko ◽  
T G Fedoskova ◽  
L V Luss
Keyword(s):  
Atopic Dermatitis ◽  
Chronic Urticaria ◽  
Skin Diseases ◽  
Clinical Efficiency ◽  
Allergic Skin

In the article the results of supervision over the patients with chronic urticaria (n=32) and atopic dermatitis (n=30), at the age from 2 till 55 years old treated with H^blocker levocetirizine, are presented. High clinical efficiency and safety of levocetirizine treatment of allergic skin diseases were confirmed.

scholarly journals Activated zinc pyrithione. Mechanism of action. Clinical application

2007 ◽  
Vol 4 (3) ◽  
pp. 70-75
Author(s):  
Yu K Skripkin ◽  
F I Petrovskiy ◽  
E S Fedenko ◽  
A N Pampura ◽  
D S Korostovtsev ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Clinical Application ◽  
Clinical Experience ◽  
Mechanism Of Action ◽  
Broad Spectrum ◽  
Inflammatory Infiltrate ◽  
Yeast Species ◽  
Topical Therapy ◽  
Zinc Pyrithione ◽  
Pharmacological Activities

Activated zinc pyrithione (ZP) has a number of contributory pharmacodynamic effects that provide it's efficacy in psoriasis and atopic dermatitis. Because of ZP impairs the integrity of cell membranes it is active against many bacterial and yeast species. In psoriasis and atopic dermatitis ZP therapy is accompanied by accelerated cells' apoptosis of lower layers of epidermis and atopic inflammatory infiltrate as well as by decrease in skin neutrophils and lymphocytes. The broad spectrum of pharmacological activities together with wide clinical experience worldwide endorse activated ZP as effective and safe nonsteroidal medication for topical therapy of different dermatoses and support it's use in dermatology, paediatrics and allergy.

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