scholarly journals Activated zinc pyrithione. Mechanism of action. Clinical application

2007 ◽  
Vol 4 (3) ◽  
pp. 70-75
Author(s):  
Yu K Skripkin ◽  
F I Petrovskiy ◽  
E S Fedenko ◽  
A N Pampura ◽  
D S Korostovtsev ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Clinical Application ◽  
Clinical Experience ◽  
Mechanism Of Action ◽  
Broad Spectrum ◽  
Inflammatory Infiltrate ◽  
Yeast Species ◽  
Topical Therapy ◽  
Zinc Pyrithione ◽  
Pharmacological Activities

Activated zinc pyrithione (ZP) has a number of contributory pharmacodynamic effects that provide it's efficacy in psoriasis and atopic dermatitis. Because of ZP impairs the integrity of cell membranes it is active against many bacterial and yeast species. In psoriasis and atopic dermatitis ZP therapy is accompanied by accelerated cells' apoptosis of lower layers of epidermis and atopic inflammatory infiltrate as well as by decrease in skin neutrophils and lymphocytes. The broad spectrum of pharmacological activities together with wide clinical experience worldwide endorse activated ZP as effective and safe nonsteroidal medication for topical therapy of different dermatoses and support it's use in dermatology, paediatrics and allergy.

Calcineurin Inhibitors: A Novel Approach to Canine Atopic Dermatitis

2005 ◽  
Vol 41 (2) ◽  
pp. 92-97 ◽  
Author(s):  
Rosanna Marsella
Keyword(s):  
Atopic Dermatitis ◽  
Adverse Effects ◽  
Mechanism Of Action ◽  
Broad Spectrum ◽  
Skin Diseases ◽  
Calcineurin Inhibitors ◽  
Relevant Information ◽  
Novel Approach ◽  
Allergic Skin ◽  
Traditional Therapies

The introduction of calcineurin inhibitors represents a major addition to the armamentarium of drugs available to veterinary clinicians for the management of allergic skin diseases. Both cyclosporine and tacrolimus have been proven to be well tolerated and effective for the treatment of atopic dermatitis in dogs. Although broad spectrum in their mechanism of action, they lack the major adverse effects of glucocorticoids and provide an appealing alternative to traditional therapies. The purposes of this article are to review clinically relevant information regarding these agents and to provide tips for maximizing the benefit obtained from these therapies.

Phytochemistry, Pharmacological Activities, Toxicity and Clinical Application of Momordica cochinchinensis

2019 ◽  
Vol 25 (6) ◽  
pp. 715-728 ◽  
Author(s):  
Hai-Yue Lan ◽  
Bin Zhao ◽  
Yu-Li Shen ◽  
Xiao-Qin Li ◽  
Su-Juan Wang ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Southeast Asia ◽  
Clinical Application ◽  
Chemical Constituents ◽  
Folk Medicine ◽  
Pharmacological Activities ◽  
Pharmacological Studies ◽  
Momordica Cochinchinensis

Momordica cochinchinensis (Lour.) Spreng (M. cochinchinensis) is a deciduous vine that grows in Southeast Asia. It is known as gac in Vietnam and as Red Melon in English. Gac is reputed to be extremely benificial for health and has been widely used as food and folk medicine in Southeast Asia. In China, the seed of M. cochinchinensis (Chinese name: Mu biezi) is used as traditional Chinese medicine (TCM) for the treatment of various diseases. More than 60 chemical constituents have been isolated from M. cochinchinensis. Modern pharmacological studies and clinical practice demonstrate that some chemical constituents of M. cochinchinensis possess wide pharmacological activities, such as anti-tumor, anti-oxidation, anti-inflammatory, etc. This paper reviews the phytochemistry, pharmacological activities, toxicity, and clinical application of M. cochinchinensis, aiming to bring new insights into further research and application of this ancient herb.

scholarly journals Transcutaneous penetration of a single-chain variable fragment (scFv) compared to a full-size antibody: potential tool for atopic dermatitis (AD) treatment

2021 ◽  
Vol 17 (1) ◽  
Author(s):  
Audrey Baylet ◽  
Raoul Vyumvuhore ◽  
Marine Laclaverie ◽  
Laëtitia Marchand ◽  
Carine Mainzer ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Ex Vivo ◽  
Topical Therapy ◽  
Human Keratinocytes ◽  
Raman Microspectroscopy ◽  
Interleukin 4 ◽  
Single Chain Variable Fragment ◽  
Single Chain ◽  
Administration Routes

AbstractCurrently, several biologics are used for the treatment of cutaneous pathologies such as atopic dermatitis (AD), psoriasis or skin cancers. The main administration routes are subcutaneous and intravenous injections. However, little is known about antibody penetration through the skin. The aim was to study the transcutaneous penetration of a reduced-size antibody as a single-chain variable fragment (scFv) compared to a whole antibody (Ab) and to determine its capacity to neutralize an inflammatory cytokine involved in AD such as human interleukin-4 (hIL-4). Transcutaneous penetration was evaluated by ex vivo studies on tape-stripped pig ear skin. ScFv and Ab visualization through the skin was measured by Raman microspectroscopy. In addition, hIL-4 neutralization was studied in vitro using HEK-Blue™ IL-4/IL-13 cells and normal human keratinocytes (NHKs). After 24 h of application, analysis by Raman microspectroscopy showed that scFv penetrated into the upper dermis while Ab remained on the stratum corneum. In addition, the anti-hIL4 scFv showed very efficient and dose-dependent hIL-4 neutralization. Thus, scFv penetrates through to the upper papillary dermis while Ab mostly remains on the surface, the anti-hIL4 scFv also neutralizes its target effectively suggesting its potential use as topical therapy for AD.

scholarly journals Cyclosporine-A for severe childhood atopic dermatitis: clinical experience on efficacy and safety profile

2018 ◽  
Vol 48 (5) ◽  
pp. 933-938 ◽  
Author(s):  
Hayriye SARICAOĞLU ◽  
Serkan YAZİCİ ◽  
Özge ZORLU ◽  
Emel BÜLBÜL BAŞKAN ◽  
Kenan AYDOĞAN
Keyword(s):  
Atopic Dermatitis ◽  
Clinical Experience ◽  
Cyclosporine A ◽  
Safety Profile ◽  
Efficacy And Safety

scholarly journals Pharmacognosy, phytochemistry, pharmacology and clinical application of Ginkgo biloba

2021 ◽  
Vol 16 (2) ◽  
pp. 229-240
Author(s):  
Manisha P. More ◽  
Anuja S. Motule ◽  
Prajakta N. Dongare ◽  
Prerna A. Patinge ◽  
Rahul D. Jawarkar ◽  
...  
Keyword(s):  
Cancer Treatment ◽  
Clinical Application ◽  
Ginkgo Biloba ◽  
Ginkgolide B ◽  
Pharmacological Profile ◽  
Pharmacological Activities ◽  
Potential Source ◽  
Ginkgolide A ◽  
Phytochemical Constituents ◽  
Different Parts

In the present review, we are highlighted various pharmacognostic and pharmacological aspects of the different parts of plant Ginkgo biloba. Leaves are mainly potential source of phytochemical constituents. The plant encompasses variety of pharmacological activities namely antioxidant, hypolipidemic, antibacterial, etc. The pharmacological profile of plant is mainly attributed to the presence of chemicals such as Ginkgolide A, Ginkgolide B, Ginkgolide C, Bilobalide, Ginkgotoxin, ginkgolides and bilobalide are the major constituents. The pills with the highest concentration of plant extract (100 mg) allow the intake of the highest antioxidants concentration. It is also used along with 5-flurouracil in cancer treatment. There is need to explore more activities of the plant.

scholarly journals Overcoming drug delivery barriers and challenges in topical therapy of atopic dermatitis: A nanotechnological perspective

2022 ◽  
Vol 147 ◽  
pp. 112633
Author(s):  
Chetna Hemrajani ◽  
Poonam Negi ◽  
Arun Parashar ◽  
Gaurav Gupta ◽  
Niraj Kumar Jha ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Atopic Dermatitis ◽  
Topical Therapy ◽  
Barriers And Challenges
Sign in / Sign up

Export Citation Format

Share Document