scholarly journals Correspondence

2011 ◽  
Vol 10 (3) ◽  
pp. 165-166
Keyword(s):  
Septic Shock ◽  
Severe Sepsis ◽  
Acute Medicine ◽  
Medicine Journal ◽  
Definition Of ◽  
Sepsis And Septic Shock

Contemporary definition of sepsis and the role of the Acute Medicine trainee in the management Dear Editor, We read with interest the review of shock by Rowe and Fletcher in the Acute Medicine Journal,1 and would like to make some comments regarding the contemporary definition of sepsis and the role of the Acute Medicine trainee in the management of severe sepsis and septic shock.

scholarly journals The Role of Natural Killer Cells in Sepsis

2011 ◽  
Vol 2011 ◽  
pp. 1-8 ◽  
Author(s):  
Laurent Chiche ◽  
Jean-Marie Forel ◽  
Guillemette Thomas ◽  
Catherine Farnarier ◽  
Fréderic Vely ◽  
...  
Keyword(s):  
Septic Shock ◽  
Severe Sepsis ◽  
Nk Cells ◽  
Natural Killer ◽  
Immune Cells ◽  
Potential Role ◽  
Nk Cell ◽  
Early Stage ◽  
Sepsis And Septic Shock

Severe sepsis and septic shock are still deadly conditions urging to develop novel therapies. A better understanding of the complex modifications of the immune system of septic patients is needed for the development of innovative immunointerventions. Natural killer (NK) cells are characterized as CD3−NKp46+CD56+cells that can be cytotoxic and/or produce high amounts of cytokines such as IFN-γ. NK cells are also engaged in crosstalks with other immune cells, such as dendritic cells, macrophages, and neutrophils. During the early stage of septic shock, NK cells may play a key role in the promotion of the systemic inflammation, as suggested in mice models. Alternatively, at a later stage, NK cells-acquired dysfunction could favor nosocomial infections and mortality. Standardized biological tools defining patients' NK cell status during the different stages of sepsis are mandatory to guide potential immuno-interventions. Herein, we review the potential role of NK cells during severe sepsis and septic shock.

scholarly journals Updating the evidence for the role of corticosteroids in severe sepsis and septic shock: a Bayesian meta-analytic perspective

Critical Care ◽  
2010 ◽  
Vol 14 (4) ◽  
pp. R134 ◽  
Author(s):  
John L Moran ◽  
Petra L Graham ◽  
Sue Rockliff ◽  
Andrew D Bersten
Keyword(s):  
Septic Shock ◽  
Severe Sepsis ◽  
Sepsis And Septic Shock

A critical role of pentraxin 3 in severe sepsis and septic shock

2017 ◽  
Vol 48 (1) ◽  
pp. e12855 ◽  
Author(s):  
Federico Carbone ◽  
Fabrizio Montecucco ◽  
Fabio Rigamonti
Keyword(s):  
Septic Shock ◽  
Severe Sepsis ◽  
Critical Role ◽  
Pentraxin 3 ◽  
Sepsis And Septic Shock

scholarly journals Role of Admission Troponin‐T and Serial Troponin‐T Testing in Predicting Outcomes in Severe Sepsis and Septic Shock

2017 ◽  
Vol 6 (9) ◽  
Author(s):  
Saraschandra Vallabhajosyula ◽  
Ankit Sakhuja ◽  
Jeffrey B. Geske ◽  
Mukesh Kumar ◽  
Joseph T. Poterucha ◽  
...  
Keyword(s):  
Septic Shock ◽  
Severe Sepsis ◽  
Troponin T ◽  
Sepsis And Septic Shock

Classification of sepsis, severe sepsis and septic shock: the impact of minor variations in data capture and definition of SIRS criteria

2012 ◽  
Vol 38 (5) ◽  
pp. 811-819 ◽  
Author(s):  
Peter M. C. Klein Klouwenberg ◽  
David S. Y. Ong ◽  
Marc J. M. Bonten ◽  
Olaf L. Cremer
Keyword(s):  
Septic Shock ◽  
Severe Sepsis ◽  
Data Capture ◽  
Definition Of ◽  
Sepsis And Septic Shock ◽  
The Impact ◽  
Sirs Criteria
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