A critical role of pentraxin 3 in severe sepsis and septic shock

2017 ◽  
Vol 48 (1) ◽  
pp. e12855 ◽  
Author(s):  
Federico Carbone ◽  
Fabrizio Montecucco ◽  
Fabio Rigamonti
Keyword(s):  
Septic Shock ◽  
Severe Sepsis ◽  
Critical Role ◽  
Pentraxin 3 ◽  
Sepsis And Septic Shock

scholarly journals The Role of Natural Killer Cells in Sepsis

2011 ◽  
Vol 2011 ◽  
pp. 1-8 ◽  
Author(s):  
Laurent Chiche ◽  
Jean-Marie Forel ◽  
Guillemette Thomas ◽  
Catherine Farnarier ◽  
Fréderic Vely ◽  
...  
Keyword(s):  
Septic Shock ◽  
Severe Sepsis ◽  
Nk Cells ◽  
Natural Killer ◽  
Immune Cells ◽  
Potential Role ◽  
Nk Cell ◽  
Early Stage ◽  
Sepsis And Septic Shock

Severe sepsis and septic shock are still deadly conditions urging to develop novel therapies. A better understanding of the complex modifications of the immune system of septic patients is needed for the development of innovative immunointerventions. Natural killer (NK) cells are characterized as CD3−NKp46+CD56+cells that can be cytotoxic and/or produce high amounts of cytokines such as IFN-γ. NK cells are also engaged in crosstalks with other immune cells, such as dendritic cells, macrophages, and neutrophils. During the early stage of septic shock, NK cells may play a key role in the promotion of the systemic inflammation, as suggested in mice models. Alternatively, at a later stage, NK cells-acquired dysfunction could favor nosocomial infections and mortality. Standardized biological tools defining patients' NK cell status during the different stages of sepsis are mandatory to guide potential immuno-interventions. Herein, we review the potential role of NK cells during severe sepsis and septic shock.

scholarly journals Updating the evidence for the role of corticosteroids in severe sepsis and septic shock: a Bayesian meta-analytic perspective

Critical Care ◽  
2010 ◽  
Vol 14 (4) ◽  
pp. R134 ◽  
Author(s):  
John L Moran ◽  
Petra L Graham ◽  
Sue Rockliff ◽  
Andrew D Bersten
Keyword(s):  
Septic Shock ◽  
Severe Sepsis ◽  
Sepsis And Septic Shock

scholarly journals Early persisting elevation of plasma Pentraxin 3 is associated with mortality and with coagulation impairment in severe sepsis and septic shock

Critical Care ◽  
2010 ◽  
Vol 14 (Suppl 1) ◽  
pp. P23
Author(s):  
A Coppadoro ◽  
T Mauri ◽  
G Bellani ◽  
N Patroniti ◽  
M Cugno ◽  
...  
Keyword(s):  
Septic Shock ◽  
Severe Sepsis ◽  
Pentraxin 3 ◽  
Sepsis And Septic Shock

scholarly journals Role of Admission Troponin‐T and Serial Troponin‐T Testing in Predicting Outcomes in Severe Sepsis and Septic Shock

2017 ◽  
Vol 6 (9) ◽  
Author(s):  
Saraschandra Vallabhajosyula ◽  
Ankit Sakhuja ◽  
Jeffrey B. Geske ◽  
Mukesh Kumar ◽  
Joseph T. Poterucha ◽  
...  
Keyword(s):  
Septic Shock ◽  
Severe Sepsis ◽  
Troponin T ◽  
Sepsis And Septic Shock
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