scholarly journals Shatavari (Asparagus Racemosus) - The Best Female Reproductive Tonic

2021 ◽  
Vol 8 (5) ◽  
pp. 73-84
Author(s):  
Shifali Thakur ◽  
Hemlata Kaurav ◽  
Gitika Chaudhary
Keyword(s):  
Biological Activities ◽  
Chemical Constituents ◽  
World Health ◽  
Asparagus Racemosus ◽  
Pharmacological Properties ◽  
General Description ◽  
Wound Healing Effect ◽  
Ancient Times ◽  
Health Organization ◽  
Herbal Plant

It is recommended by the World health organization (WHO) the most of the world’s population depends on herbal medicine for their health care. Shatavari, Asparagus racemosus is one of the most significant restorative plant employed by Ayurvedic Vaidyas from ancient times. This herbal plant has wide selection of biological activities and described as a Rasayan in Ayurvedic literatures. Root is the most used part of Shatavari by Ayurvedic Vaidyas. It is one of the most common herbal plant used worldwide and possess various chemical constituents such as Racemoside A, B, C, Shatavarins, Asparanin A, Immunoside, 27 α-dimethyl-1β, 2β,3β-trihydroxy-25-spirost-4-en-19β-oic, 27 α-dimethyl-1β, 2β,3β-trihydroxy-25-spirost-4-en-19β-oic and many others. It is described as a tonic and have lactogenic properties. It has an extensive use in Nervine disorders, Acid peptic diseases, several contagious ailments and as a immunomodulant. It is primarily used in female ailments mainly as galactagogic and several menstrual problems. The chemical constituents of Asparagus racemosus have many pharmacological activities such as antibacterial, antiviral, anti-inflammatory, wound healing effect, antidepressant, anti-anxiety, antifertility and also skin cancer, pigmentation and many other. Much scientific research on Asparagus racemosus has been conducted over the last years to investigate chemical and pharmacological properties. In this review, the general description, phytochemicals, pharmacological properties, ayurvedic properties and folk uses of Asparagus racemosus are briefly explained. Keywords: Shatavari, Ayurveda, Saponins, Menstrual disorders, Anti-ulcer, Immunomodulatory.

scholarly journals A Review on the Cosmeceutical and External Applications ofNigella sativa

2017 ◽  
Vol 2017 ◽  
pp. 1-6 ◽  
Author(s):  
Ahmad M. Eid ◽  
Nagib A. Elmarzugi ◽  
Laila M. Abu Ayyash ◽  
Maher N. Sawafta ◽  
Hadeel I. Daana
Keyword(s):  
Health Care ◽  
Wound Healing ◽  
Nigella Sativa ◽  
Chemical Constituents ◽  
Acne Vulgaris ◽  
World Health ◽  
Pharmacological Effects ◽  
The World ◽  
Wound Healing Effect ◽  
Health Organization

It is estimated by the World Health Organization (WHO) that most of the world’s population depends on herbal medicine for their health care.Nigella sativa (N. sativa),also known as black-caraway and as “Kalonji,” is a well-known seed all over the world. It is one of the most common medicinal plants worldwide and contains many useful chemical constituents that we can find in its fixed oil, such as thymoquinone, thymohydroquinone, dithymoquinone, thymol, nigellicine, carvacrol, nigellimine, nigellicine, nigellidine, and alpha-hederin. Due to these numerous important ingredients it was found that it affects different areas of our body and has many pharmacological effects as antibacterial, antiviral, anti-inflammatory, and wound healing effect and also for acne vulgaris, skin cancer, pigmentation, and many cosmeceutical applications. Based on the folklore usage ofN. sativaseeds and oil, they are used in various systems of food and medicines. The aim of this article is to provide a detailed survey of the literature of cosmeceutical and external applications ofN. sativawhich is expected to stimulate further studies on this subject.

Medicinal Chemistry of Alternative Therapeutics: Novelty and Hopes with Genus Ammannia

2019 ◽  
Vol 19 (10) ◽  
pp. 784-794 ◽  
Author(s):  
Harish C. Upadhyay
Keyword(s):  
Traditional Medicine ◽  
Biological Activities ◽  
World Health ◽  
Biologically Relevant ◽  
Traditional Medicines ◽  
Drug Molecules ◽  
Health Organization ◽  
Tract Infections ◽  
Pharmacologically Active ◽  
Herbal Formulations

The plants have formed the basis of folklore remedy since the beginning of human civilization. The cumulative human endeavor and experience over a period of thousands of years developed into well to organize traditional medicine systems viz. Ayurvedic, Unani, Chinese amongst others. Across the world, traditional medicine is either the mainstay of health care or serves as a complement to modern drugs. In view of worldwide use of traditional medicines, World Health Organization launched ‘WHO-Traditional Medicine Strategy 2014-2023’ for the development of strong policies regarding knowledge-base, safety, quality-control and effectiveness of traditional/alternative therapeutics for national health systems. Besides their use in traditional medicine, plants have always been a good source of modern drug/pharmacologically active molecules. More than half of the modern pharmaceuticals are either plant isolates or their derivatives. The plant-based drugs are not only effective, but have better compatibility with human biological systems because of more biologically relevant chemistry, hence lesser side effects. Some of the species of genus Ammannia (Lythraceae) have been reported for their magical medicinal values. Many herbal formulations containing Ammannia spp. have been patented for treatment of serious diseases/disorders like cancer, spinal disease, human female infertility, chronic tonsillitis, pelvic inflammatory disease, treatment of bladder stones, urinary tract infections, dermatitis etc. The uses of Ammannia spp. in traditional medicine have been further verified by the biological activities of their extracts as well as isolation of bioactive phytomolecules. The current review provides details about Ammannia spp.; its use in folklore remedy, herbal formulations, biological activities of extracts, isolation of bioactive phytomolecules and SAR study of semi-synthetic derivatives to analyze the possibility of new drug molecules of plant origin.

scholarly journals Loranthus micranthusLinn.: Biological Activities and Phytochemistry

2013 ◽  
Vol 2013 ◽  
pp. 1-9 ◽  
Author(s):  
Soheil Zorofchian Moghadamtousi ◽  
Maryam Hajrezaei ◽  
Habsah Abdul Kadir ◽  
Keivan Zandi
Keyword(s):  
Medicinal Plant ◽  
Mineral Nutrition ◽  
Current Knowledge ◽  
Biological Activities ◽  
Chemical Constituents ◽  
Pharmacological Properties ◽  
Host Trees ◽  
Trees And Shrubs ◽  
Respective Host

Loranthus micranthusLinn. is a medicinal plant from the Loranthaceae family commonly known as an eastern Nigeria species of the African mistletoe and is widely used in folkloric medicine to cure various ailments and diseases. It is semiparasitic plant because of growing on various host trees and shrubs and absorbing mineral nutrition and water from respective host. Hence, the phytochemicals and biological activities ofL. micranthusdemonstrated strong host and harvesting period dependency. The leaves have been proved to possess immunomodulatory, antidiabetic, antimicrobial, antihypertensive, antioxidant, antidiarrhoeal, and hypolipidemic activities. This review summarizes the information and findings concerning the current knowledge on the biological activities, pharmacological properties, toxicity, and chemical constituents ofLoranthus micranthus.

scholarly journals A Review on Woodfordia fruticosa Kurz (Dhatki): Ayurvedic, Folk and Modern Uses

2021 ◽  
Vol 11 (3) ◽  
pp. 126-131
Author(s):  
Shifali Thakur ◽  
Hemlata Kaurav ◽  
Gitika Chaudhary
Keyword(s):  
Biological Activities ◽  
Chemical Constituents ◽  
Anthraquinone Glycosides ◽  
Medicinal Use ◽  
The Family ◽  
History Of ◽  
Phytochemical Compounds ◽  
Therapeutic Activities ◽  
Herbal Plant ◽  
Woodfordia Fruticosa

Woodfordia fruticosa kurz is an herbal plant that belongs to the family Lythraceae. This plant is widely distributed throughout the tropical and subtropical regions of India, Sri Lanka, China, Malaysia, Indonesia, Japan and Pakistan. The plant possesses a long history of medicinal use. The flowers of Woodfordia fruticosa are recorded to possess potent therapeutic values. The various phytochemicals isolated from this plant are tannins, flavonoids, anthraquinone, glycosides and polyphenols. The extract of flowers and leaves are associated with useful therapeutic activities. These phytochemical compounds have many pharmacological properties such as antimicrobial, hepatoprotective, cardioprotective, antioxidant, antiulcer, immunomodulatory, antifertility and anti-tumor.  These pharmacological activities of Woodfordia fruticosa plant are also mentioned in the literature of ayurveda, yunani and other traditional systems of medicine. This review is intended to provide brief information on the plant Woodfordia fruticosa on the basis of chemical constituents, folk usage, ayurvedic usage, modern usage and its biological activities.  Keywords: Woodfordia fruticosa, antimicrobial, Ayurvedic, flavonoids, Octacosanol 

scholarly journals Groundwater Quality Assessment of Abandoned Dumpsite in Osogbo Suburb, Nigeria: Hydrogeological and Geophysical Condition Six Years after Initial Study

2021 ◽  
Vol 25 (7) ◽  
pp. 1213-1219
Author(s):  
A.O. Ojo ◽  
A.C. Oyelami ◽  
E.M. Babafemi
Keyword(s):  
Ground Penetrating Radar ◽  
Chemical Constituents ◽  
Quality Standard ◽  
Initial Study ◽  
Unconfined Aquifer ◽  
World Health ◽  
Geophysical Investigation ◽  
High Concentrations ◽  
Health Organization ◽  
Ground Penetrating

In this paper, we describe the result of a recent hydrogeological and geophysical investigation carried out within and around Aduramigba - Onibu-Eja Estate dumpsite with the aim of detecting evidence of contamination as well as depths to contamination of the groundwater after a previous study six years ago. Twenty water samples from shallow water wells and boreholes were analyzed for their physico-chemical constituents while five vertical electrical soundings and five electromagnetic ground penetrating radar surveys were conducted. The result shows high concentrations of anions of nitrates (NO3-), bicarbonates (HCO3-), chloride (Cl-) and sulphate (SO42-) with values of 73.97 mg/l, 91.5 mg/l, 331.2 mg/l, 222.4 mg/l respectively, cations values of Mg2+, Fe2+, Na+, and K+ having value of 25.44 mg/l, 6.23 mg/l, 37.31 mg/l and 35.41 mg/l, respectively, which were far above the World Health Organization (WHO) and Nigeria Drinking Water Quality Standard (NDWS). Heavy metal components such as Lead, Zinc, Copper and Nickel were also observed to be on the high side, having been contributed from effluents from rust metallic materials cum chemicals dumped within the dumpsite. Detailed geophysical study reveal the depth to contamination at between 4.1 meters in VES 3 to 5.9 meters in VES 2 with resistivity as low as 5.12 Ωm in VES 2 to 7.12 Ωm in VES 3 while ground penetrating radar (GPR) revealed that the leachate has permeated to a depth of 3.5 – 5.25 meters in traverse 4 and 4.0 – 6.0 meters in traverse 3 which correspond to the depth to unconfined aquifer within the dumpsite. The study conclude that this would pose a greater threat to residents living in this vicinity and as such, this might have contributed to the closure of the dumpsite.

scholarly journals Gmelina arborea: chemical constituents, pharmacological activities and applications

2017 ◽  
Vol 9 (4) ◽  
pp. 528 ◽  
Author(s):  
Charu Arora ◽  
Vinita Tamrakar
Keyword(s):  
Biological Activities ◽  
Chemical Constituents ◽  
Iridoid Glycoside ◽  
Immunomodulatory Activity ◽  
Gmelina Arborea ◽  
Β Cells ◽  
Pharmacological Activities ◽  
Flavone Glycoside ◽  
Ancient Times ◽  
Medicinal Properties

<p><em>Gmelina arborea </em>(<em>G. arborea</em>) is a bio-prospective plant belonging to family verbenaceae. It is widely used for it’s medicinal properties from ancient times. The present paper comprehensively reviewed the traditional uses, medicinal properties and chemical constituents isolated from <em>G. arborea</em> based on literature reported as well as critical analysis of the research. The present article is aimed to provide information on recent advances and new foundations and direction for further exploring <em>G. arborea </em>for its applications. Pharmacological research reviewed that <em>G. arborea </em>possess various medicinal properties and biological  activities including antidiuretic, antidiarrhoeal, antipyretic, antianalgesic, antioxidant, antidiabetic, antihelmintic, antibacterial, antifungal, cardiopotective, insecticidal, antiulcer, gastro-protective, anticancer, antihyperlipidemic and immunomodulatory activity. It has been reported for its applications in treatment of bone fracture, hypertension and regeneration of β-cells. The main chemical constituents of <em>G. arborea</em> include lignans, iridoid glycoside, flavonoids, flavons, flavone glycoside and sterols. The present review provides all the references and beneficial directions to explore further application of <em>G. arborea.</em></p>

Exploring Azatidinone Moiety: An Insight into its Anti-tubercular Potency

Drug Research ◽  
2021 ◽  
Author(s):  
Rina Das ◽  
Dinesh Kumar Mehta ◽  
Meenakshi Dhanawat
Keyword(s):  
Biological Activities ◽  
Biological Response ◽  
Antitubercular Activity ◽  
World Health ◽  
Cyclic Amide ◽  
Improper Use ◽  
Health Organization ◽  
Almost All ◽  
Tuberculosis Therapy ◽  
Insight Into

AbstractTB is becoming a worldwide problem and it was declared since 1993 by the World Health Organization (WHO), a global health emergency. The current problem of tuberculosis therapy is the emergence of multi-drug resistant (MDR) strains, caused by the improper use of antibiotics in chemotherapy of TB patients. Azatidinones, a β-lactam cyclic amide with four atoms in a ring, has been considered as a magic moiety (wonder nucleus) which possesses almost all types of biological activities. This diversity in the biological response profile has attracted the attention of many researchers to explore this skeleton to its multiple potential against several activities. Present article is sincere attempt to review chemistry, method of synthesis of azatidinones and to study azatidinones synthesized in last few years which have shown potent antitubercular activity.

scholarly journals Definition and Measurement of Follicle Stimulating Hormone

2000 ◽  
Vol 21 (1) ◽  
pp. 5-22 ◽  
Author(s):  
Matthew P. Rose ◽  
Rose E. Gaines Das ◽  
Adam H. Balen
Keyword(s):  
Single Molecule ◽  
Early Recognition ◽  
Biological Activities ◽  
World Health ◽  
In Vitro Assays ◽  
Assay Method ◽  
Endocrine Activity ◽  
Health Organization

Abstract FSH has a key role in the development and function of the reproductive system and is widely used both diagnostically and therapeutically in developmental and reproductive medicine. The accurate measurement of FSH levels, in patients for diagnosis and monitoring and in therapeutic preparations for clinical use, is essential for safe and successful treatment. Historically, FSH was defined on the basis of classical in vivo endocrine activity, and early therapeutic preparations were calibrated using in vivo bioassays. There was early recognition that reference preparations were required for calibration if the results from different laboratories were to be comparable. In response to the perceived need, the World Health Organization established the first standard for such preparations in 1959. Subsequent developments in biotechnology have led to recognition that there is no single molecule that can be uniquely defined as FSH, and that FSH can induce a range of biological activities. Several highly purified standards for FSH are now available, but discontinuity and heterogeneity of estimates of FSH activity in terms of these standards made using in vitro assays and binding assays have been noted. It is thus essential that any measurement of FSH include specification both of the standard with which the measured FSH is compared and the assay method used for that comparison.

scholarly journals Acetylcholinesterase Inhibitory Potential of Various Sesquiterpene Analogues for Alzheimer’s Disease Therapy

Biomolecules ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 350
Author(s):  
Ashwani Arya ◽  
Rubal Chahal ◽  
Rekha Rao ◽  
Md. Habibur Rahman ◽  
Deepak Kaushik ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Biological Activities ◽  
Structural Diversity ◽  
Time Frame ◽  
World Health ◽  
Cholinergic Transmission ◽  
Disease Therapy ◽  
Inhibitory Potential ◽  
Health Organization

Alzheimer’s disease (AD) is a gradually growing irreversible illness of the brain that almost affects every fifth person (aged > 80 years) in the world. World Health Organization (WHO) also revealed that the prevalence of this disease will enhance (upto double) significantly upto 2030. The poor cholinergic transmission at the synapse is considered to be one of the main reasons behind the progression and occurrence of this disorder. Natural inhibitors of acetylcholine (ACh) such as galanthamine and rivastigmine are used commercially in the treatmentof AD. The biomolecules such assesquiterpenes, possess a great structural diversity and are responsible for a plethora of pharmacological properties. The potential of various sesquiterpenes as anticholinesterase has been reviewed in this article. For this purpose, the various databases, mainly PubMed, Scopus, and Web of Science were investigatedwith different keywords such as “sesquiterpenes+acetylcholinesterase” and “sesquiterpenes+cholinesterase+inhibitors” in the surveyed time frame (2010–2020). A vast literature was evident in the last decade, which affirms the potential of various sesquiterpenes in the improvement of cholinergic transmission by inhibiting the AChE. After data analysis, it was found that 12 compounds out of a total of 58 sesquiterpenes were reported to possess IC50 < 9μM and can be considered as potential candidates for the improvement of learning and memory. Sesquiterpene is an important category of terpenoids, found to possess a large spectrum of biological activities. The outcome of the review clearly states that sesquiterpenes (such as amberboin, lipidiol,etc) from herbs could offer fresh, functional compounds for possible prevention and treatment of AD.

scholarly journals Chemical Constituents and Larvicidal Properties of n-Hexane Extract of Parinari excelsa Seeds

2021 ◽  
pp. 14-23
Author(s):  
A. Dokubo ◽  
F. G. Obomanu ◽  
N. Ebere ◽  
G. I. Ndukwe
Keyword(s):  
Larvicidal Activity ◽  
Chemical Constituents ◽  
Larval Mortality ◽  
Hexane Extract ◽  
World Health ◽  
Gas Chromatography Mass Spectrometry ◽  
Chemical Compositions ◽  
Vector Borne Diseases ◽  
Standard Procedures ◽  
Health Organization

The study was conducted to investigate the chemical compositions and larvicidal effect of n-hexane extract of Parinari excelsa seeds against fourth instar larvae of Culex mosquito after 24 h and 48 h exposure. The chemical composition of n-hexane extract of P. excelsa seeds were analyzed using Gas Chromatography-Mass Spectrometry (GC-MS). Larvicidal activity was performed following standard procedures of World Health Organization (WHO). GC-MS analysis showed that the seed extract of P. excelsa contained hexadecyl phenyl carbonate with highest percentage (7.502%, RT=26.39), followed by tetradecyl phenyl carbonate (5.77%, RT=25.90), 1-methyl cyclohex-3-enyldodecyl fumarate (5.70%, RT=24.58), decyl phenyl carbonate (4.70%, RT=28.64) and the lowest, octadecyl-2,2,2-trichloroethyl carbonate (0.62%, RT=13.71). The result showed significant (p<0.05) mortality of larvae  in 24 h and 48 h of exposure. However, the highest larval mortality  was recorded at 48 h exposure. Result of regression analysis indicated that mortality rate positively correlated with concentration having a regression coefficient (R) close to one in each exposure case. The estimated lethal concentrations (LC50) for 24 h and 48 h exposure were 2.056±0.176 µg/ml and 0.429±0.150 µg/ml respectively. This indicates that larvicidal activity recorded for 48 h exposure was 4.8 times more than that recorded for 24 h exposure. The study demonstrated that n-hexane extract of P. excelsa seeds exhibited larvicidal potential and can be utilized as biopesticides to minimize the multiplication of mosquitoes that transmit vector borne diseases.

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