scholarly journals Microvascular density and immunohistochemical expression of VEGF, VEGFR-1 and VEGFR-2 in benign prostatic hyperplasia, high-grade prostate intraepithelial neoplasia and prostate cancer

2016 ◽  
Vol 69 (1) ◽  
Keyword(s):  
Prostate Cancer ◽  
Benign Prostatic Hyperplasia ◽  
Intraepithelial Neoplasia ◽  
Prostatic Hyperplasia ◽  
Microvascular Density ◽  
High Grade ◽  
Immunohistochemical Expression ◽  
Prostate Intraepithelial Neoplasia

scholarly journals Correlation of serum free prostate-specific antigen level with histological findings in patients with prostatic disease

1970 ◽  
Vol 8 (2) ◽  
pp. 158-163 ◽  
Author(s):  
M Lakhey ◽  
R Ghimire ◽  
R Shrestha ◽  
AD Bhatta
Keyword(s):  
Prostate Cancer ◽  
Benign Prostatic Hyperplasia ◽  
Intraepithelial Neoplasia ◽  
Prostatic Intraepithelial Neoplasia ◽  
Prostatic Hyperplasia ◽  
Free Form ◽  
High Grade ◽  
Prostatic Disease ◽  
Active Inflammation ◽  
The Relationship

Background: Prostate Specifi c Antigen (PSA) has been widely used in the diagnosis and management of patients with prostate cancer. It may be elevated in other prostatic diseases and surgical procedures. PSA exists in two forms, a major bound form (cPSA) and a free form (fPSA). Objectives: The objective of the study was to determine the relationship between serum fPSA levels and histologic findings in biopsy specimens of men with prostatic disease. Material and methods: This study includes 91 patients planned for transurethral resection of prostate (TURP). Blood samples were collected before TURP and tested for fPSA. Histology of the tissue samples collected after TURP were studied and the relationship with fPSA analysed using SPSS 11.5. Results: The median values for benign, premalignant and malignant lesions were 1.8ng/ml, 4.5ng/ml and 13.20ng/ml respectively (p<0.001). Most cases of benign prostatic hyperplasia(BPH) without inflammation had fPSA levels <2ng/ ml, while most with active inflammation had levels >5ng/ml. Low grade prostatic intraepithelial neoplasia (LGPIN) saw levels <5ng/ml while high grade intraepithelial neoplasia (HGPIN) and prostate cancer (PCa) had levels > 5ng/mL (p<0.05). For detection of high grade lesions (HGPIN and PCa), the sensitivity and specificity of fPSA level > 5ng/ml was found to be 88.8% and 90.2% respectively. Conclusions: Serum fPSA is elevated marginally in patients with BPH without inflammation. Active inflammation and high grade lesions are associated with fPSA level more than 5 ng/ml. Key words: Benign prostatic hyperplasia; fPSA; prostate cancer; prostatic intraepithelial neoplasia. DOI: 10.3126/kumj.v8i2.3550 Kathmandu University Medical Journal (2010), Vol. 8, No. 2, Issue 30, 158-163  

The use of ProstaDoz in patients with benign prostatic hyperplasia and coexistent high-grade prostatic intraepithelial neoplasia

Urologiia ◽  
2017 ◽  
Vol 5_2017 ◽  
pp. 58-62
Author(s):  
A.G. Antonov Antonov ◽  
V.V. Gordeev Gordeev ◽  
S.B. Fedorchuk Fedorchuk ◽  
D.O. Laptev Laptev ◽  
◽  
...  
Keyword(s):  
Benign Prostatic Hyperplasia ◽  
Intraepithelial Neoplasia ◽  
Prostatic Intraepithelial Neoplasia ◽  
Prostatic Hyperplasia ◽  
High Grade

High-grade prostate intraepithelial neoplasia shares cytogenetic alterations with invasive prostate cancer

The Prostate ◽  
2001 ◽  
Vol 47 (1) ◽  
pp. 29-35 ◽  
Author(s):  
Antonio Alcaraz ◽  
Miguel A. Barranco ◽  
Juan M. Corral ◽  
Maria J. Ribal ◽  
Ana Carrió ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Intraepithelial Neoplasia ◽  
High Grade ◽  
Prostate Intraepithelial Neoplasia
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