scholarly journals High grade prostate intraepithelial neoplasia (PIN) is a PSA-independent risk factor for prostate cancer in African American men: Results from a pilot study

2013 ◽  
Vol 331 (2) ◽  
pp. 154-157 ◽  
Author(s):  
Ganna Chornokur ◽  
Gang Han ◽  
Richard Tanner ◽  
Hui-Yi Lin ◽  
B. Lee Green ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
African American ◽  
Risk Factor ◽  
Pilot Study ◽  
Independent Risk Factor ◽  
African American Men ◽  
Intraepithelial Neoplasia ◽  
High Grade ◽  
Prostate Intraepithelial Neoplasia

605 COMBINATION OF ADH GENE POLYMORPHISM AND ALCOHOL CONSUMPTION CONSTITUTES A NOVEL PROSTATE CANCER RISK FACTOR IN AFRICAN-AMERICAN MEN

2011 ◽  
Vol 185 (4S) ◽  
Author(s):  
Lionel L. Bañez ◽  
Cathrine Hoyo ◽  
Elizabeth M. Masko ◽  
Elizabeth E. Calloway ◽  
Kathleen H. Shuler ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
African American ◽  
Risk Factor ◽  
Alcohol Consumption ◽  
Cancer Risk ◽  
Gene Polymorphism ◽  
African American Men ◽  
Prostate Cancer Risk ◽  
Cancer Risk Factor ◽  
Adh Gene

Diabetes mellitus, race, and the odds of high-grade prostate cancer in men diagnosed with prostate cancer in the United States.

2011 ◽  
Vol 29 (7_suppl) ◽  
pp. 180-180 ◽  
Author(s):  
T. Mitin ◽  
M. Chen ◽  
B. J. Moran ◽  
D. E. Dosoretz ◽  
M. J. Katin ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Diabetes Mellitus ◽  
United States ◽  
Logistic Regression ◽  
African American ◽  
Risk Factor ◽  
The United States ◽  
High Grade ◽  
Newly Diagnosed ◽  
Independent Association

180 Background: African American (AA) men present more frequently with high-grade prostate cancer (PCa) and are also more likely to have diabetes mellitus (DM). We evaluated whether there is an independent association between DM and the risk of high-grade PCa in men diagnosed with PCa, adjusting for the known predictors of high-grade PCa including AA race. Methods: Between 1991 and 2009 15,377 men newly diagnosed with PCa and treated at 1 of 26 centers, were analyzed in 2 cohorts. Multivariable logistic regression was performed to evaluate whether a diagnosis of DM was associated with the odds of Gleason 7 or 8 to 10 PCa, adjusting for AA race, advancing age, PSA level, and DRE findings. Results: AA men (AOR, 1.87; 95% CI, 1.04-3.37, P=0.04) and non-AA men (AOR, 1.61; 95% CI, 1.34-1.93; P<0.001) with diabetes were more likely to have GS 8 to 10 versus GS 6 or less PCa, compared to non-diabetic men. AA as compared to non-AA race was not significantly associated with the odds of having GS 8 to 10 as compared to 6 or less PCa, both in men with a diagnosis of DM (AOR, 1.47; 95% CI, 0.87-2.50; P=0.15) and without DM (AOR, 1.27; 95% CI, 0.92-1.74, P=0.14). AA race, however (AOR, 1.37; 95% CI, 1.17-1.60, P<0.001), but not DM (AOR 1.09; 95% CI, 0.97-1.22, P=0.16), was associated with GS 7 versus 6 or less PCa. Conclusions: A diagnosis of DM is a risk factor for presenting with Gleason 8 to 10 PCa independent of race. [Table: see text] No significant financial relationships to disclose.

High-grade prostate intraepithelial neoplasia shares cytogenetic alterations with invasive prostate cancer

The Prostate ◽  
2001 ◽  
Vol 47 (1) ◽  
pp. 29-35 ◽  
Author(s):  
Antonio Alcaraz ◽  
Miguel A. Barranco ◽  
Juan M. Corral ◽  
Maria J. Ribal ◽  
Ana Carrió ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Intraepithelial Neoplasia ◽  
High Grade ◽  
Prostate Intraepithelial Neoplasia

scholarly journals MP09-19 LOW FREE TESTOSTERONE IS AN INDEPENDENT RISK FACTOR FOR HIGH GRADE PROSTATE CANCER

2019 ◽  
Vol 201 (Supplement 4) ◽  
Author(s):  
Maxwell Towe* ◽  
Linda M. Huynh ◽  
Farouk M. El-Khatib ◽  
Mohamad Osman ◽  
Faysal A. Yafi ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Risk Factor ◽  
Independent Risk Factor ◽  
Free Testosterone ◽  
High Grade

PD07-04 CLINICAL PERFORMANCE OF AN EPIGENETIC ASSAY TO IDENTIFY OCCULT HIGH-GRADE PROSTATE CANCER IN AFRICAN AMERICAN MEN

2017 ◽  
Vol 197 (4S) ◽  
Author(s):  
Leander Van Neste ◽  
Carlton Barnswell ◽  
Mark Jalkut ◽  
Ronald Tutrone ◽  
James Sylora ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
African American ◽  
Clinical Performance ◽  
African American Men ◽  
High Grade

HIGH GRADE PROSTATIC INTRAEPITHELIAL NEOPLASIA (PIN) ON INITIAL PROSTATE BIOPSY IS NOT A RISK FACTOR FOR PROSTATE CANCER AT REPEAT BIOPSY

2009 ◽  
Vol 181 (4) ◽  
pp. 656 ◽  
Author(s):  
Hendrik Isbarn ◽  
Christopher R Porter ◽  
Pierre I Karakiewicz ◽  
Mike Traver ◽  
Tony Woodruff ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Risk Factor ◽  
Prostate Biopsy ◽  
Intraepithelial Neoplasia ◽  
Prostatic Intraepithelial Neoplasia ◽  
Repeat Biopsy ◽  
High Grade
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