scholarly journals 3.2 - Enantioselective Fluorescence Response of Molecularly Imprinted Polymers (MIPs) toward Carbobenzyloxy- (Cbz) protected Amino Acids

2013 ◽  
Author(s):  
M. Biyikal ◽  
W. Wan ◽  
K. Rurack ◽  
R. Wagner ◽  
B. Sellergren
Keyword(s):  
Amino Acids ◽  
Molecularly Imprinted Polymers ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Fluorescence Response

scholarly journals Molecularly imprinted polymers in biological applications

BioTechniques ◽  
2020 ◽  
Vol 69 (6) ◽  
pp. 406-419
Author(s):  
Zahra El-Schich ◽  
Yuecheng Zhang ◽  
Marek Feith ◽  
Sarah Beyer ◽  
Louise Sternbæk ◽  
...  
Keyword(s):  
Amino Acids ◽  
Molecularly Imprinted Polymers ◽  
Low Cost ◽  
Cancer Diagnostics ◽  
Biological Applications ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Recognition Elements ◽  
Synthesis Procedure

Molecularly imprinted polymers (MIPs) are currently widely used and further developed for biological applications. The MIP synthesis procedure is a key process, and a wide variety of protocols exist. The templates that are used for imprinting vary from the smallest glycosylated glycan structures or even amino acids to whole proteins or bacteria. The low cost, quick preparation, stability and reproducibility have been highlighted as advantages of MIPs. The biological applications utilizing MIPs discussed here include enzyme-linked assays, sensors, in vivo applications, drug delivery, cancer diagnostics and more. Indeed, there are numerous examples of how MIPs can be used as recognition elements similar to natural antibodies.

Chiral recognition and separation of β2-amino acids using non-covalently molecularly imprinted polymers

The Analyst ◽  
2004 ◽  
Vol 129 (12) ◽  
pp. 1211-1215 ◽  
Author(s):  
Yong-Ho Shim ◽  
Ecevit Yilmaz ◽  
Solange Lavielle ◽  
Karsten Haupt
Keyword(s):  
Amino Acids ◽  
Molecularly Imprinted Polymers ◽  
Chiral Recognition ◽  
Molecularly Imprinted ◽  
Imprinted Polymers

scholarly journals Preparation and application of molecularly imprinted polymers for chiral HPLC separation of biologically active substances

2020 ◽  
Vol 19 (1) ◽  
pp. 1-18
Author(s):  
Anna Lomenova ◽  
Katarína Hroboňová
Keyword(s):  
Amino Acids ◽  
Stationary Phase ◽  
Molecularly Imprinted Polymers ◽  
Biologically Active Substances ◽  
Biologically Active ◽  
Chiral Hplc ◽  
Hplc Separation ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Active Substances

Chiral separations are one of the important analytical tasks, since there are increasing demands for production of enantiomerically pure compounds. The separation and determination of enantiomers find applications in pharmaceutical and food analysis, and it is necessary to pay attention to the development and improvement of chiral analytical methods. High performance liquid chromatography (HPLC) with chiral stationary phase (CSP) based on molecularly imprinted polymers (MIPs) is perspective way. One of the main advantage of these stationary phases is the possibility of predetermining the elution order of enantiomers. The presented work is focused on the methods of preparation and the applications of selective sorption materials (MIPs) in the field of HPLC separation of biologically active substances, amino acids. This review contains comprehensive informations about MIP-amino acid synthesis: compositions of polymerization mixture (monomer, template, cross-linker, porogen), type of polymerization and polymerization conditions, what can affect final efficiency of enantioseparation. The most used porogen was toluene, crosslinker ethylene glycol dimethacrylate (EDMA) and initiator azoisobutyronitrile (AIBN). MIP CSP prepared for derivatized amino acids show better results (higher resolution) than MIP prepared for underivatized amino acids. MIP are very promising material to be used as stationary phase in HPLC, although further developments and new approaches are necessary to fully exploit their potential.

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