Molecular recognition in synthetic polymers. Enantiomeric resolution of amide derivatives of amino acids on molecularly imprinted polymers

1989 ◽  
Vol 2 (1) ◽  
pp. 1-5 ◽  
Author(s):  
Daniel J. O'Shannessy ◽  
Lars I. Andersson ◽  
Klaus Mosbach
Keyword(s):  
Amino Acids ◽  
Molecular Recognition ◽  
Molecularly Imprinted Polymers ◽  
Synthetic Polymers ◽  
Enantiomeric Resolution ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Amide Derivatives ◽  
Derivatives Of

scholarly journals Molecular Recognition: Perspective and a New Approach

Sensors ◽  
2021 ◽  
Vol 21 (8) ◽  
pp. 2757
Author(s):  
W. Rudolf Seitz ◽  
Casey J. Grenier ◽  
John R. Csoros ◽  
Rongfang Yang ◽  
Tianyu Ren
Keyword(s):  
Molecular Recognition ◽  
Molecularly Imprinted Polymers ◽  
Binding Sites ◽  
Binding Kinetics ◽  
Molecularly Imprinted ◽  
New Approach ◽  
Imprinted Polymers ◽  
High Affinity ◽  
Water Blocking ◽  
High Level

This perspective presents an overview of approaches to the preparation of molecular recognition agents for chemical sensing. These approaches include chemical synthesis, using catalysts from biological systems, partitioning, aptamers, antibodies and molecularly imprinted polymers. The latter three approaches are general in that they can be applied with a large number of analytes, both proteins and smaller molecules like drugs and hormones. Aptamers and antibodies bind analytes rapidly while molecularly imprinted polymers bind much more slowly. Most molecularly imprinted polymers, formed by polymerizing in the presence of a template, contain a high level of covalent crosslinker that causes the polymer to form a separate phase. This results in a material that is rigid with low affinity for analyte and slow binding kinetics. Our approach to templating is to use predominantly or exclusively noncovalent crosslinks. This results in soluble templated polymers that bind analyte rapidly with high affinity. The biggest challenge of this approach is that the chains are tangled when the templated polymer is dissolved in water, blocking access to binding sites.

Signaling molecularly imprinted polymers: molecular recognition-based sensing materials

2005 ◽  
Vol 5 (5) ◽  
pp. 263-275 ◽  
Author(s):  
Toshifumi Takeuchi ◽  
Takashi Mukawa ◽  
Hideyuki Shinmori
Keyword(s):  
Molecular Recognition ◽  
Molecularly Imprinted Polymers ◽  
Molecularly Imprinted ◽  
Imprinted Polymers

scholarly journals Molecularly imprinted polymers in biological applications

BioTechniques ◽  
2020 ◽  
Vol 69 (6) ◽  
pp. 406-419
Author(s):  
Zahra El-Schich ◽  
Yuecheng Zhang ◽  
Marek Feith ◽  
Sarah Beyer ◽  
Louise Sternbæk ◽  
...  
Keyword(s):  
Amino Acids ◽  
Molecularly Imprinted Polymers ◽  
Low Cost ◽  
Cancer Diagnostics ◽  
Biological Applications ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Recognition Elements ◽  
Synthesis Procedure

Molecularly imprinted polymers (MIPs) are currently widely used and further developed for biological applications. The MIP synthesis procedure is a key process, and a wide variety of protocols exist. The templates that are used for imprinting vary from the smallest glycosylated glycan structures or even amino acids to whole proteins or bacteria. The low cost, quick preparation, stability and reproducibility have been highlighted as advantages of MIPs. The biological applications utilizing MIPs discussed here include enzyme-linked assays, sensors, in vivo applications, drug delivery, cancer diagnostics and more. Indeed, there are numerous examples of how MIPs can be used as recognition elements similar to natural antibodies.

A simple and benign protocol for the synthesis of deep eutectic solvents-based hydrophilic molecularly imprinted resin in water for excellent selective molecular recognition in aqueous phase

2021 ◽  
Author(s):  
Mingwei Wang ◽  
Fengxia Qiao ◽  
Hongyuan Yan
Keyword(s):  
Molecular Recognition ◽  
Organic Solvents ◽  
Aqueous Phase ◽  
Molecularly Imprinted Polymers ◽  
Deep Eutectic Solvents ◽  
Green Process ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Aqueous Environments

Molecularly imprinted polymers (MIPs) are conventionally synthesized in organic solvents, resulting in poor compatibility with water and weak molecular recognition of targets in aqueous environments; hence, developing a green process...

Iniferter-mediated grafting of molecularly imprinted polymers on porous silica beads for the enantiomeric resolution of drugs

2015 ◽  
Vol 29 (3) ◽  
pp. 106-114 ◽  
Author(s):  
Raquel Gutiérrez-Climente ◽  
Alberto Gómez-Caballero ◽  
Mahadeo Halhalli ◽  
Börje Sellergren ◽  
M. Aránzazu Goicolea ◽  
...  
Keyword(s):  
Molecularly Imprinted Polymers ◽  
Porous Silica ◽  
Enantiomeric Resolution ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Silica Beads
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