scholarly journals Molecularly imprinted polymers in biological applications

BioTechniques ◽  
2020 ◽  
Vol 69 (6) ◽  
pp. 406-419
Author(s):  
Zahra El-Schich ◽  
Yuecheng Zhang ◽  
Marek Feith ◽  
Sarah Beyer ◽  
Louise Sternbæk ◽  
...  
Keyword(s):  
Amino Acids ◽  
Molecularly Imprinted Polymers ◽  
Low Cost ◽  
Cancer Diagnostics ◽  
Biological Applications ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Recognition Elements ◽  
Synthesis Procedure

Molecularly imprinted polymers (MIPs) are currently widely used and further developed for biological applications. The MIP synthesis procedure is a key process, and a wide variety of protocols exist. The templates that are used for imprinting vary from the smallest glycosylated glycan structures or even amino acids to whole proteins or bacteria. The low cost, quick preparation, stability and reproducibility have been highlighted as advantages of MIPs. The biological applications utilizing MIPs discussed here include enzyme-linked assays, sensors, in vivo applications, drug delivery, cancer diagnostics and more. Indeed, there are numerous examples of how MIPs can be used as recognition elements similar to natural antibodies.

scholarly journals Molecularly Imprinted Polymers Combined with Electrochemical Sensors for Food Contaminants Analysis

Molecules ◽  
2021 ◽  
Vol 26 (15) ◽  
pp. 4607
Author(s):  
Dounia Elfadil ◽  
Abderrahman Lamaoui ◽  
Flavio Della Pelle ◽  
Aziz Amine ◽  
Dario Compagnone
Keyword(s):  
Food Safety ◽  
Molecularly Imprinted Polymers ◽  
Electrochemical Sensors ◽  
Low Cost ◽  
Electrochemical Analysis ◽  
Ease Of Use ◽  
Electrochemical Sensing ◽  
Food Contaminants ◽  
Molecularly Imprinted ◽  
Imprinted Polymers

Detection of relevant contaminants using screening approaches is a key issue to ensure food safety and respect for the regulatory limits established. Electrochemical sensors present several advantages such as rapidity; ease of use; possibility of on-site analysis and low cost. The lack of selectivity for electrochemical sensors working in complex samples as food may be overcome by coupling them with molecularly imprinted polymers (MIPs). MIPs are synthetic materials that mimic biological receptors and are produced by the polymerization of functional monomers in presence of a target analyte. This paper critically reviews and discusses the recent progress in MIP-based electrochemical sensors for food safety. A brief introduction on MIPs and electrochemical sensors is given; followed by a discussion of the recent achievements for various MIPs-based electrochemical sensors for food contaminants analysis. Both electropolymerization and chemical synthesis of MIP-based electrochemical sensing are discussed as well as the relevant applications of MIPs used in sample preparation and then coupled to electrochemical analysis. Future perspectives and challenges have been eventually given.

scholarly journals In Vivo Recognition of Human Vascular Endothelial Growth Factor by Molecularly Imprinted Polymers

Nano Letters ◽  
2017 ◽  
Vol 17 (4) ◽  
pp. 2307-2312 ◽  
Author(s):  
Alessandra Cecchini ◽  
Vittoria Raffa ◽  
Francesco Canfarotta ◽  
Giovanni Signore ◽  
Sergey Piletsky ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Molecularly Imprinted Polymers ◽  
Vascular Endothelial ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Endothelial Growth Factor

A High-Throughput Screening of N-Carbobenzoxy-L-Tryptophan Imprinted Polymers and their Application for Monolithic Chiral Stationary Phase

2012 ◽  
Vol 535-537 ◽  
pp. 1525-1528 ◽  
Author(s):  
Jian Qi ◽  
Li Guo ◽  
Hai Feng Sang
Keyword(s):  
Stationary Phase ◽  
Molecularly Imprinted Polymers ◽  
High Throughput Screening ◽  
Chiral Stationary Phase ◽  
Binding Capacity ◽  
Low Cost ◽  
Small Scale ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Chiral Selectivity

Molecular imprinting is a technique to prepare polymers with predetermined selectivity, specific recognition and predesigned affinity to a desired molecule. The stability and low cost of molecularly imprinted polymers (MIPs) render them attractive for a broad range of applications. Currently, MIP technique has been widely used in chiral separation. In this study, a series of molecularly imprinted polymers for N-Carbobenzoxy-L-tryptophan (N-Cbz-L-Trp) synthesized in different conditions were prepared in a small scale to simulate the monolithic chiral stationary phases (CSPs) primarily. By coupling in situ processing and batch rebinding evaluation, the type of functional monomers, which likely to affect the chiral selectivity of MIPs, was investigated. It was found that a MIP comprising a mixture of functional monomer 4-vinylpyridine (4-VP) and porogen 1-dodecanol/toluene exhibited the highest binding capacity and chiral selectivity for N-Carbobenzoxy-L-tryptophan. Thereafter, the monolithic MIP synthesized in screened optimum condition is used as chiral stationary phase in HPLC, which shows favourable separating capacity.

scholarly journals Hybrids Molecularly Imprinted Polymers: The Future of Nanomedicine?

2021 ◽  
Author(s):  
Maylis Garnier ◽  
Michele Sabbah ◽  
Christine Ménager ◽  
Nébéwia Griffete
Keyword(s):  
Molecularly Imprinted Polymers ◽  
Improve Patient Care ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Wide Range ◽  
Lack Of Control ◽  
Inorganic Nanomaterials ◽  
Complex Detection ◽  
Improve Patient

Molecularly imprinted polymers (MIPs) have been widely used in nanomedicine during the last few years. However, their potential is limited by their intrinsic properties resulting, for instance, in lack of control in drug release processes or complex detection for in vivo imaging. Recent attempts in creating hybrid nanomaterials combining MIPs with inorganic nanomaterials succeeded in providing a wide range of new interesting properties suitable for nanomedicine. Through this review, we aim to illustrate how hybrids molecularly imprinted polymers may improve patient care with enhanced imaging, treatments and combination of both.

Molecularly Imprinted Polymers as Selective Recognition Elements in Optical Sensing

2008 ◽  
Vol 4 (4) ◽  
pp. 316-340 ◽  
Author(s):  
Maria Moreno-Bondi ◽  
Fernando Navarro-Villoslada ◽  
Elena Benito-Pena ◽  
Javier Urraca
Keyword(s):  
Molecularly Imprinted Polymers ◽  
Optical Sensing ◽  
Selective Recognition ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Recognition Elements

Chiral recognition and separation of β2-amino acids using non-covalently molecularly imprinted polymers

The Analyst ◽  
2004 ◽  
Vol 129 (12) ◽  
pp. 1211-1215 ◽  
Author(s):  
Yong-Ho Shim ◽  
Ecevit Yilmaz ◽  
Solange Lavielle ◽  
Karsten Haupt
Keyword(s):  
Amino Acids ◽  
Molecularly Imprinted Polymers ◽  
Chiral Recognition ◽  
Molecularly Imprinted ◽  
Imprinted Polymers

scholarly journals Molecularly Imprinted Polymers and Surface Imprinted Polymers Based Electrochemical Biosensor for Infectious Diseases

Sensors ◽  
2020 ◽  
Vol 20 (4) ◽  
pp. 996 ◽  
Author(s):  
Feiyun Cui ◽  
Zhiru Zhou ◽  
H. Susan Zhou
Keyword(s):  
Infectious Diseases ◽  
Molecularly Imprinted Polymers ◽  
Low Cost ◽  
Electrochemical Biosensors ◽  
Critical Element ◽  
Preparation Methods ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Artificial Receptors ◽  
Stability And Accuracy

Owing to their merits of simple, fast, sensitive, and low cost, electrochemical biosensors have been widely used for the diagnosis of infectious diseases. As a critical element, the receptor determines the selectivity, stability, and accuracy of the electrochemical biosensors. Molecularly imprinted polymers (MIPs) and surface imprinted polymers (SIPs) have great potential to be robust artificial receptors. Therefore, extensive studies have been reported to develop MIPs/SIPs for the detection of infectious diseases with high selectivity and reliability. In this review, we discuss mechanisms of recognition events between imprinted polymers with different biomarkers, such as signaling molecules, microbial toxins, viruses, and bacterial and fungal cells. Then, various preparation methods of MIPs/SIPs for electrochemical biosensors are summarized. Especially, the methods of electropolymerization and micro-contact imprinting are emphasized. Furthermore, applications of MIPs/SIPs based electrochemical biosensors for infectious disease detection are highlighted. At last, challenges and perspectives are discussed.

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