scholarly journals SYNTHESIS OF 1,2,3-TRIAZOLES BASED ON PROPARGYL ETHERS OF CARBAMATE

2020 ◽  
pp. 40-42
Keyword(s):  
Biological Activity ◽  
Chemical Structure ◽  
Inflammatory Activity ◽  
Triazole Derivatives ◽  
Anti Inflammatory

By the interaction of propargyl esters of carbamate derivatives with phenylazide, 1,2,3- triazole derivatives were synthesized. Their anti-inflammatory activity was subsequently studied.During the study of biological activity, a relationship was established between the anti- inflammatory activity and the chemical structure in the studied series of 1,2,3-triazole derivatives.

Chemical structure and anti-inflammatory activity of a branched polysaccharide isolated from Phellinus baumii

2021 ◽  
pp. 118214
Author(s):  
Yuqing Sun ◽  
Jinxi Huo ◽  
Shi Zhong ◽  
Jianxun Zhu ◽  
Yougui Li ◽  
...  
Keyword(s):  
Chemical Structure ◽  
Inflammatory Activity ◽  
Phellinus Baumii ◽  
Anti Inflammatory

AN UPDATE ON THE SYNTHESIS OF BENZOXAZOLES

2017 ◽  
Vol 10 (10) ◽  
pp. 48 ◽  
Author(s):  
Jyothi M ◽  
Ramchander Merugu
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Biological Activity ◽  
Biological Activities ◽  
Starting Material ◽  
Bioactive Molecules ◽  
Living Systems ◽  
Inflammatory Activity ◽  
Anti Inflammatory

Benzoxazoles being structurally similar to bases adenine and guanine interact with biomolecules present in living systems. These compounds possess antimicrobial, central nervous system activities, antihyperglycemic potentiating activity, analgesic, and anti-inflammatory activity. It can also be used as starting material for other bioactive molecules. Modifications in structure and the biological profiles of new generations of benzoxazoles were found to be more potent with enhanced biological activity. Considering all these, we have prepared this review and discussed the synthesis and biological activities of benzoxazoles.

scholarly journals Synthesis and Prognosis of Anti-inflammatory Activity of 2-substituted 5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine-4(3h)-one

2021 ◽  
Vol 7 (12) ◽  
pp. 25-33
Author(s):  
A. Chiriapkin ◽  
I. Kodonidi ◽  
A. Ivchenko ◽  
L. Smirnova
Keyword(s):  
Acetic Acid ◽  
Biological Activity ◽  
Dimethyl Sulfoxide ◽  
In Silico ◽  
Glacial Acetic Acid ◽  
Inflammatory Activity ◽  
Modified Method ◽  
Anti Inflammatory ◽  
Catalytic Addition ◽  
Derivatives Of

The article presents a modified method for the synthesis of 2-substituted 5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine-4(3H)-one and the predict of their anti-inflammatory activity. The proposed method for obtaining tetrahydrothienopyrimidine derivatives is preparatively effective and simple. Their synthesis was carried out by heterocyclization of azomethine derivatives of 2-amino-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide in the medium of glacial acetic acid with the catalytic addition of dimethyl sulfoxide. Preliminary prognosis of anti-inflammatory activity in silico method allowed us to identify the most promising compounds. Of these, the 4b structure containing a 2-hydroxyphenyl fragment in the second position of pyrimidine-4(3H)-one may be of the greatest interest. It seems appropriate to further study the spectrum of biological activity of the studied compounds.

scholarly journals Aminoacids Derivatives with a Potential Anti-inflammatory Activity

2016 ◽  
Vol 5 (4) ◽  
pp. 323 ◽  
Author(s):  
Valeriu Sunel ◽  
Marcel Popa ◽  
Liliana Verestiuc ◽  
Claudia Ivanov ◽  
Aura Angelica Popa
Keyword(s):  
Biological Activity ◽  
Acute Toxicity ◽  
Acetylsalicylic Acid ◽  
Hplc Method ◽  
Point Of View ◽  
Inflammatory Activity ◽  
Benzimidazole Derivatives ◽  
Reaction Products ◽  
Anti Inflammatory ◽  
Physical And Chemical

The paper presents the synthesis of benzimidazole derivatives starting from asparagic acid. The reaction products were analysed from physical and chemical point of view and their biological activity (acute toxicity, anti-inflammatory activity and gastric tolerance) was evaluated. The product association with acetylsalicylic acid (Aspirin) improves its anti-inflammatory activity (higher with 38%). For acetylsalicylic acid dosing, in mixtures with benzimidazole derivatives, a new HPLC method has been proposed. The method is reproducible, selective and easy to manipulate. The derivatives based on benzimidazole and asparagic acid and their associates with acetylsalicylic acid present good anti-inflammatory properties.

Relationship of chemical structure and anti-inflammatory activity of dihydrocorynantheol and its analogues

2013 ◽  
Vol 65 (5) ◽  
pp. 1263-1271
Author(s):  
Patrícia Pozzatti ◽  
Gustavo O. dos Reis ◽  
Danielle F. Pereira ◽  
Heros Horst ◽  
Leandro Espindola ◽  
...  
Keyword(s):  
Chemical Structure ◽  
Inflammatory Activity ◽  
Anti Inflammatory ◽  
Relationship Of

Synthesis and anti-inflammatory activity of new 1,2,4-triazole derivatives

2015 ◽  
Vol 25 (13) ◽  
pp. 2664-2667 ◽  
Author(s):  
Renata Paprocka ◽  
Malgorzata Wiese ◽  
Andrzej Eljaszewicz ◽  
Anna Helmin-Basa ◽  
Andrzej Gzella ◽  
...  
Keyword(s):  
Inflammatory Activity ◽  
Triazole Derivatives ◽  
Anti Inflammatory

scholarly journals Thermal stability, antioxidant, and anti-inflammatory activity of curcumin and its degradation product 4-vinyl guaiacol

2015 ◽  
Vol 6 (3) ◽  
pp. 887-893 ◽  
Author(s):  
Tuba Esatbeyoglu ◽  
Katrin Ulbrich ◽  
Clemens Rehberg ◽  
Sascha Rohn ◽  
Gerald Rimbach
Keyword(s):  
Thermal Stability ◽  
Biological Activity ◽  
Degradation Product ◽  
Inflammatory Activity ◽  
Anti Inflammatory

The curcumin degradation product 4-vinyl guaiacol exhibits biological activity.

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