scholarly journals Aminoacids Derivatives with a Potential Anti-inflammatory Activity

2016 ◽  
Vol 5 (4) ◽  
pp. 323 ◽  
Author(s):  
Valeriu Sunel ◽  
Marcel Popa ◽  
Liliana Verestiuc ◽  
Claudia Ivanov ◽  
Aura Angelica Popa
Keyword(s):  
Biological Activity ◽  
Acute Toxicity ◽  
Acetylsalicylic Acid ◽  
Hplc Method ◽  
Point Of View ◽  
Inflammatory Activity ◽  
Benzimidazole Derivatives ◽  
Reaction Products ◽  
Anti Inflammatory ◽  
Physical And Chemical

The paper presents the synthesis of benzimidazole derivatives starting from asparagic acid. The reaction products were analysed from physical and chemical point of view and their biological activity (acute toxicity, anti-inflammatory activity and gastric tolerance) was evaluated. The product association with acetylsalicylic acid (Aspirin) improves its anti-inflammatory activity (higher with 38%). For acetylsalicylic acid dosing, in mixtures with benzimidazole derivatives, a new HPLC method has been proposed. The method is reproducible, selective and easy to manipulate. The derivatives based on benzimidazole and asparagic acid and their associates with acetylsalicylic acid present good anti-inflammatory properties.

Anti-Inflammatory Activity and Sub-Acute Toxicity of Artemetin1

Planta Medica ◽  
1990 ◽  
Vol 56 (01) ◽  
pp. 36-40 ◽  
Author(s):  
Jayme Sertié ◽  
Aulus Basile ◽  
Sylvio Panizza ◽  
Amabile Matida ◽  
Raymond Zelnik
Keyword(s):  
Acute Toxicity ◽  
Inflammatory Activity ◽  
Anti Inflammatory

Reduced anti-inflammatory activity of acetylsalicylic acid maltol ester, aspalatone

1994 ◽  
Vol 17 (3) ◽  
pp. 166-169 ◽  
Author(s):  
Byung Hoon Han ◽  
Dae-Yeon Suh ◽  
Hyun Ok Yang ◽  
Song Jin Lee ◽  
Hyun Pyo Kim
Keyword(s):  
Acetylsalicylic Acid ◽  
Inflammatory Activity ◽  
Anti Inflammatory

AN UPDATE ON THE SYNTHESIS OF BENZOXAZOLES

2017 ◽  
Vol 10 (10) ◽  
pp. 48 ◽  
Author(s):  
Jyothi M ◽  
Ramchander Merugu
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Biological Activity ◽  
Biological Activities ◽  
Starting Material ◽  
Bioactive Molecules ◽  
Living Systems ◽  
Inflammatory Activity ◽  
Anti Inflammatory

Benzoxazoles being structurally similar to bases adenine and guanine interact with biomolecules present in living systems. These compounds possess antimicrobial, central nervous system activities, antihyperglycemic potentiating activity, analgesic, and anti-inflammatory activity. It can also be used as starting material for other bioactive molecules. Modifications in structure and the biological profiles of new generations of benzoxazoles were found to be more potent with enhanced biological activity. Considering all these, we have prepared this review and discussed the synthesis and biological activities of benzoxazoles.

scholarly journals Synthesis and Prognosis of Anti-inflammatory Activity of 2-substituted 5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine-4(3h)-one

2021 ◽  
Vol 7 (12) ◽  
pp. 25-33
Author(s):  
A. Chiriapkin ◽  
I. Kodonidi ◽  
A. Ivchenko ◽  
L. Smirnova
Keyword(s):  
Acetic Acid ◽  
Biological Activity ◽  
Dimethyl Sulfoxide ◽  
In Silico ◽  
Glacial Acetic Acid ◽  
Inflammatory Activity ◽  
Modified Method ◽  
Anti Inflammatory ◽  
Catalytic Addition ◽  
Derivatives Of

The article presents a modified method for the synthesis of 2-substituted 5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine-4(3H)-one and the predict of their anti-inflammatory activity. The proposed method for obtaining tetrahydrothienopyrimidine derivatives is preparatively effective and simple. Their synthesis was carried out by heterocyclization of azomethine derivatives of 2-amino-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide in the medium of glacial acetic acid with the catalytic addition of dimethyl sulfoxide. Preliminary prognosis of anti-inflammatory activity in silico method allowed us to identify the most promising compounds. Of these, the 4b structure containing a 2-hydroxyphenyl fragment in the second position of pyrimidine-4(3H)-one may be of the greatest interest. It seems appropriate to further study the spectrum of biological activity of the studied compounds.

In vivo anti-inflammatory activity and docking study of newly synthesized benzimidazole derivatives bearing oxadiazole and morpholine rings

2017 ◽  
Vol 70 ◽  
pp. 107-117 ◽  
Author(s):  
Ankita Rathore ◽  
Raja Sudhakar ◽  
Mohamed Jawed Ahsan ◽  
Abuzer Ali ◽  
Naidu Subbarao ◽  
...  
Keyword(s):  
Docking Study ◽  
Inflammatory Activity ◽  
Benzimidazole Derivatives ◽  
Anti Inflammatory

Synthesis, p38 Kinase Inhibitory and Anti-inflammatory Activity of New Substituted Benzimidazole Derivatives

2013 ◽  
Vol 9 (1) ◽  
pp. 91-99 ◽  
Author(s):  
Ravindra G. Kulkarni ◽  
Stefan A. Laufer ◽  
Chandrashekhar V. M ◽  
Achaiah Garlapati
Keyword(s):  
Inflammatory Activity ◽  
Benzimidazole Derivatives ◽  
P38 Kinase ◽  
Anti Inflammatory

scholarly journals Anti-inflammatory activity and acute toxicity studies of hydroalcoholic extract of Herissantia tiubae

2016 ◽  
Vol 26 (2) ◽  
pp. 225-232 ◽  
Author(s):  
Ana L.A. Lima ◽  
Adriano F. Alves ◽  
Aline L. Xavier ◽  
Talissa Mozzini-Monteiro ◽  
Theresa R.R. Oliveira ◽  
...  
Keyword(s):  
Acute Toxicity ◽  
Inflammatory Activity ◽  
Hydroalcoholic Extract ◽  
Toxicity Studies ◽  
Anti Inflammatory
Sign in / Sign up

Export Citation Format

Share Document