scholarly journals Evaluation of maternal serum prolactin in pregnant women with gestational Diabetes mellitus

2021 ◽  
Vol 23 (10) ◽  
pp. 195-205
Author(s):  
Manal Matlab Hassan ◽  
◽  
Risala A. Ali ◽  
Keyword(s):  
Diabetes Mellitus ◽  
Glucose Metabolism ◽  
Pregnant Women ◽  
Normal Glucose Tolerance ◽  
Maternal Serum ◽  
Serum Prolactin ◽  
P Value ◽  
Serum Prolactin Level ◽  
Normal Glucose ◽  
The Mean

Maintenance of normal glucose metabolism during pregnancy is of particular importance. Prolactin may be a mediator in pathogenesis of impaired glucose metabolism. This study aimed to assess the levels of maternal serum prolactin in pregnant women with gestational Diabetes mellitus (GDM). This prospective observational study was done at AL– Emamain AL- Kadhemain Medical City/ Department of Obstetrics and Gynecology in Baghdad/ Iraq during the period from 1st March to 1st October 2018 on 150 pregnant women who were referred for OGTT for different indications. For all included women, maternal serum prolactin level and 75 gm OGTT was performed. The results showed that the mean±SD of maternal serum prolactin levels for all included women was (135.14±22.67) ng/ml and there was significantly negative correlation with (1hr) and (2hr) blood glucose levels of 75 gm OGTT at p value (0.027), (0.003) respectively. Out of 150 women included in the study (52) women diagnosed to have GDM and (98) women to have normal glucose tolerance. The mean±SD of maternal serum prolactin level was (123.6±13.7) ng/ml in GDM group which is significantly lower in comparison with mean ±SD (141.3±24.1) ng/ml in normal group at p value (0.0001). It can be concluded that women with GDM showed significantly lower serum prolactin levels in comparison with levels in women with normal glucose tolerance.

Impact of Glucose Metabolism Disorders on IGF-1 Levels in Patients with Acromegaly

2018 ◽  
Vol 50 (05) ◽  
pp. 408-413 ◽  
Author(s):  
Sema Dogansen ◽  
Gulsah Yalin ◽  
Seher Tanrikulu ◽  
Sema Yarman
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Glucose Metabolism ◽  
Glucose Tolerance ◽  
Normal Glucose Tolerance ◽  
Glucose Metabolism Disorders ◽  
Insulin Resistant ◽  
Normal Glucose ◽  
Resistant Group ◽  
The Impact

AbstractIn this study, we aimed to evaluate the presence of glucose metabolism abnormalities and their impact on IGF-1 levels in patients with acromegaly. Ninety-three patients with acromegaly (n=93; 52 males/41 females) were included in this study. Patients were separated into three groups such as; normal glucose tolerance (n=23, 25%), prediabetes (n=38, 41%), and diabetes mellitus (n=32, 34%). Insulin resistance was calculated with homeostasis model assessment (HOMA). HOMA-IR > 2.5 or ≤2.5 were defined as insulin resistant or noninsulin resistant groups, respectively. Groups were compared in terms of factors that may be associated with glucose metabolism abnormalities. IGF-1% ULN (upper limit of normal)/GH ratios were used to evaluate the impact of glucose metabolism abnormalities on IGF-1 levels. Patients with diabetes mellitus were significantly older with an increased frequency of hypertension (p<0.001, p=0.01, respectively). IGF-1% ULN/GH ratio was significantly lower in prediabetes group than in normal glucose tolerance group (p=0.04). Similarly IGF-1% ULN/GH ratio was significantly lower in insulin resistant group than in noninsulin resistant group (p=0.04). Baseline and suppressed GH levels were significantly higher in insulin resistant group than in noninsulin resistant group (p=0.024, p<0.001, respectively). IGF-1% ULN/GH ratio is a useful marker indicating glucose metabolism disorders and IGF-1 levels might be inappropriately lower in acromegalic patients with insulin resistance or prediabetes. We suggest that IGF-1 levels should be re-evaluated after the improvement of insulin resistance or glycemic regulation for the successful management of patients with acromegaly.

Effect of short-term bromocriptine treatment on amniotic fluid prolactin concentration in the first half of pregnancy

1981 ◽  
Vol 97 (4) ◽  
pp. 559-561 ◽  
Author(s):  
P. Lehtovirta ◽  
T. Ranta
Keyword(s):  
Amniotic Fluid ◽  
Pregnant Women ◽  
Dopamine Receptors ◽  
Prolactin Level ◽  
Prolactin Secretion ◽  
Maternal Serum ◽  
Serum Prolactin ◽  
Fluid Level ◽  
Serum Prolactin Level ◽  
Short Term

Abstract. The effect of short-term bromocriptine treatment on amniotic fluid and maternal prolactin concentrations was studied in 9 pregnant women in the first half of pregnancy. Bromocriptine suppressed the maternal serum prolactin level, but had no effect on the amniotic fluid level. Since both foetal and maternal prolactin secretion are suppressed by bromocriptine our results suggest that amniotic fluid prolactin is produced by extrapituitary tissues, which do not contain dopamine receptors.

scholarly journals The Role of Osteocalcin in Placenta Function in Gestational Diabetes Mellitus

2021 ◽  
Author(s):  
Liang Song ◽  
Yiming Huang ◽  
Junqing Long ◽  
Yuanfan Li ◽  
Zongqin Pan ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Glucose Tolerance ◽  
Gestational Diabetes Mellitus ◽  
Umbilical Vein ◽  
Normal Glucose Tolerance ◽  
Maternal Serum ◽  
Diabetes Mellitus Group ◽  
Human Trophoblast ◽  
Normal Glucose

Abstract Background: Evidence for osteocalcin role in glucose and energy metabolism is increasing. However, little is known about osteocalcin function in gestational diabetes mellitus. The aim of this study is to examine the associations between osteocalcin and gestational diabetes mellitus. Method: 36 patients with gestational diabetes mellitus and 40 normal glucose tolerance controls were recruited in the Maternal and Child Health Hospital Guangxi Zhuang Autonomous Region from May to August 2018. Total osteocalcin and biochemical indexes of maternal serum and umbilical vein serum were analyzed. Transcriptome of placenta were sequenced. Human trophoblast JAR cells were used for evaluated the affection of osteocalcin on trophoblast In vitro. There were no significant differences with maternal serum total osteocalcin levels between gestational diabetes mellitus and normal glucose tolerance groups. The gestational diabetes mellitus group has lower umbilical vein serum total osteocalcin (51.46 ng/mL ± 24.29 Vs 67.00 ng/mL ± 25.33, P = 0.008 ), lower adiponectin (1099.72 μg/L ± 102.65 Vs 1235.85 μg/L ± 94.63, P < 0.001), higher leptin (7.41 μg/L ± 0.28 Vs 6.02 μg/L ± 0.31, P ＜ 0.001). A significant relationship existed between umbilical vein serum total osteocalcin levels and leptin (r = -0.456, P = 0.007). Osteocalcin promote JAR trophoblast cells proliferation and HCG synthesis. 36 correlated gene modules of placental transcriptome were identified through weighted gene co-expression network analysis, 2 of them were associated with osteocalcin. Conclusion: lower osteocalcin in umbilical vein serum is associated with gestational diabetes mellitus, osteocalcin may regulate placenta function via adiponectin.

scholarly journals Comparison of Serum Lipid Profile between Gestational Diabetes Mellitus and Pregnant Women with Normal Glucose Tolerance

2020 ◽  
Vol 08 (06) ◽  
pp. 148-159
Author(s):  
Mahmudul Hossain ◽  
A. K. M. Shahidur Rahman ◽  
Samira Mahjabeen ◽  
Mohona Zaman ◽  
Mohaiminul Abedin ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Glucose Tolerance ◽  
Gestational Diabetes Mellitus ◽  
Pregnant Women ◽  
Lipid Profile ◽  
Serum Lipid ◽  
Normal Glucose Tolerance ◽  
Serum Lipid Profile ◽  
Normal Glucose

SERUM PROLACTINE LEVEL IN PATIENTS OF PSORIASIS VULGARIS AND ITS CORRELATION WITH DISEASE SEVERITY: A CASE-CONTROL STUDY

2019 ◽  
Vol 3 (6) ◽  
Author(s):  
Pawan Kumar Saini ◽  
Devendra Yadav ◽  
Rozy Badyal ◽  
Suresh Jain ◽  
Arti Singh ◽  
...  
Keyword(s):  
Disease Severity ◽  
Prolactin Level ◽  
Case Control Study ◽  
Statistical Significance ◽  
Case Control ◽  
Serum Prolactin ◽  
P Value ◽  
Serum Prolactin Level ◽  
R Value ◽  
Control Study

Background: Psoriasis is an autoimmune chronic inflammatory disorder affecting the skin mediated by T-lymphocytes resulting in production of cytokines which cause hyperproliferation of keratinocytes.  Several factors and hormones like Prolactin have an action similar to these cytokines in promoting the multiplication of keratinocytes and other cells like lymphocytes and epithelial cells may have a role on the etiopathogenesis of psoriasis. Aim:-The aim of study is to compare the serum Prolactin levels in patients of psoriasis with a control group. Setting and study design: This is a case-control study conducted in the department of Dermatology, Venereology and Leprosy GMC, Kota over a period of 1year from July 2017 to June 2018 Material and method: The study included 100 cases of psoriasis (60 males and 40 females) and 100 controls similar for age and sex. Serum Prolactin levels were measured by ECLIA and results were obtained. Statistical analysis: Mean and standard deviation were calculated for each variable. Statistical significance of the results was analyzed using correlation analysis (Pearson correlation coefficient) and independent samples t-test. Statistical significance was assumed at p value<0.05. Result: Serum Prolactin level was significantly higher in cases of psoriasis compared to controls (p-value <0.001). PASI score and serum Prolactin levels were found to have a positive correlation (r value = 0.337; p-value: 0.001). No significant  correlation was found between serum levels of Prolactin and duration of disease r value= -0.034, P value =0.733). Serum Prolactin level was higher in male patients compared to females patients. Conclusion:- High serum Prolactin may be a biological marker of disease severity in psoriasis and may have a role in the pathogenesis of psoriasis. Further studies with large sample size are required to confirm this hypothesis.

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