scholarly journals Comparison of Serum Lipid Profile between Gestational Diabetes Mellitus and Pregnant Women with Normal Glucose Tolerance

2020 ◽  
Vol 08 (06) ◽  
pp. 148-159
Author(s):  
Mahmudul Hossain ◽  
A. K. M. Shahidur Rahman ◽  
Samira Mahjabeen ◽  
Mohona Zaman ◽  
Mohaiminul Abedin ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Glucose Tolerance ◽  
Gestational Diabetes Mellitus ◽  
Pregnant Women ◽  
Lipid Profile ◽  
Serum Lipid ◽  
Normal Glucose Tolerance ◽  
Serum Lipid Profile ◽  
Normal Glucose

scholarly journals Lipid Profile and Clinical Characteristics of Women with Gestational Diabetes Mellitus and Preeclampsia

2009 ◽  
Vol 28 (2) ◽  
pp. 72-81 ◽  
Author(s):  
Donovan McGrowder ◽  
Kevin Grant ◽  
Rachael Irving ◽  
Lorenzo Gordon ◽  
Tazhmoye Crawford ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Lipid Profile ◽  
Total Cholesterol ◽  
Clinical Characteristics ◽  
Hdl Cholesterol ◽  
Normal Glucose Tolerance ◽  
Increased Risk ◽  
Normal Glucose

Lipid Profile and Clinical Characteristics of Women with Gestational Diabetes Mellitus and Preeclampsia Gestational diabetes mellitus (GDM) is associated with increased risk of pregnancy-induced hypertension and other maternal and foetal complications of pregnancy. The aims of the study were to evaluate the serum lipid profile of women with GDM, and determine the number of women with GDM who have preeclampsia (PE). A retrospective study of 84 women with GDM and 90 pregnant women with normal glucose tolerance (controls) was conducted. Women with GDM had significantly higher parity (p=0.047), total cholesterol (p=0.039) and triglycerides (p=0.033), but non-significantly lower HDL-cholesterol (p=0.086) when compared to controls. Systolic blood pressure was significantly elevated in women with GDM coupled with PE (GDM-PE; p=0.015), the mean birth weight of infants born to women with GDM-PE was significantly lower than that of women with only GDM (p=0.025). Women with GDM-PE had significantly higher triglycerides (p=0.020), had to be more multi-gravida (p=0.047) with significantly elevated VLDL-cholesterol (p=0.037) when compared with women with only GDM. 11.9% of women with GDM had PE. On the basis of these findings, it can be concluded that GDM is associated with hyperlipidaemia as evident by the significantly elevated total cholesterol and triglyceride concentrations. Women with dyslipidaemia and GDM are at risk of developing preeclampsia. It is imperative that blood lipids be evaluated in women with GDM during antenatal care as it would be helpful in the early detection and treatment of PE.

scholarly journals Vitamin D Status in Women with Gestational Diabetes Mellitus during Pregnancy and Postpartum

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Anna Pleskačová ◽  
Vendula Bartáková ◽  
Lukáš Pácal ◽  
Katarína Kuricová ◽  
Jana Bělobrádková ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Vitamin D ◽  
Gestational Diabetes ◽  
Glucose Tolerance ◽  
Gestational Diabetes Mellitus ◽  
Pregnant Women ◽  
Normal Glucose Tolerance ◽  
Vitamin D Status ◽  
Early Postpartum ◽  
Pregnancy And Postpartum

Of many vitamin D extraskeletal functions, its modulatory role in insulin secretion and action is especially relevant for gestational diabetes mellitus (GDM). The aims of the present study were to determine midgestational and early postpartum vitamin D status in pregnant women with and without GDM and to describe the relationship between midgestational and postpartum vitamin D status and parallel changes of glucose tolerance. A total of 76 pregnant women (47 GDM and 29 healthy controls) were included in the study. Plasma levels of 25(OH)D were measured using an enzyme immunoassay. Vitamin D was not significantly decreased in GDM compared to controls during pregnancy; however, both groups of pregnant women exhibited high prevalence of vitamin D deficiency. Prevalence of postpartum 25(OH)D deficiency in post-GDM women remained significantly higher and their postpartum 25(OH)D levels were significantly lower compared to non-GDM counterparts. Finally, based on the oGTT repeated early postpartum persistent glucose abnormality was ascertained in 15% of post-GDM women; however, neither midgestational nor postpartum 25(OH)D levels significantly differed between subjects with GDM history and persistent postpartum glucose intolerance and those with normal glucose tolerance after delivery.

scholarly journals The Role of Osteocalcin in Placenta Function in Gestational Diabetes Mellitus

2021 ◽  
Author(s):  
Liang Song ◽  
Yiming Huang ◽  
Junqing Long ◽  
Yuanfan Li ◽  
Zongqin Pan ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Glucose Tolerance ◽  
Gestational Diabetes Mellitus ◽  
Umbilical Vein ◽  
Normal Glucose Tolerance ◽  
Maternal Serum ◽  
Diabetes Mellitus Group ◽  
Human Trophoblast ◽  
Normal Glucose

Abstract Background: Evidence for osteocalcin role in glucose and energy metabolism is increasing. However, little is known about osteocalcin function in gestational diabetes mellitus. The aim of this study is to examine the associations between osteocalcin and gestational diabetes mellitus. Method: 36 patients with gestational diabetes mellitus and 40 normal glucose tolerance controls were recruited in the Maternal and Child Health Hospital Guangxi Zhuang Autonomous Region from May to August 2018. Total osteocalcin and biochemical indexes of maternal serum and umbilical vein serum were analyzed. Transcriptome of placenta were sequenced. Human trophoblast JAR cells were used for evaluated the affection of osteocalcin on trophoblast In vitro. There were no significant differences with maternal serum total osteocalcin levels between gestational diabetes mellitus and normal glucose tolerance groups. The gestational diabetes mellitus group has lower umbilical vein serum total osteocalcin (51.46 ng/mL ± 24.29 Vs 67.00 ng/mL ± 25.33, P = 0.008 ), lower adiponectin (1099.72 μg/L ± 102.65 Vs 1235.85 μg/L ± 94.63, P < 0.001), higher leptin (7.41 μg/L ± 0.28 Vs 6.02 μg/L ± 0.31, P ＜ 0.001). A significant relationship existed between umbilical vein serum total osteocalcin levels and leptin (r = -0.456, P = 0.007). Osteocalcin promote JAR trophoblast cells proliferation and HCG synthesis. 36 correlated gene modules of placental transcriptome were identified through weighted gene co-expression network analysis, 2 of them were associated with osteocalcin. Conclusion: lower osteocalcin in umbilical vein serum is associated with gestational diabetes mellitus, osteocalcin may regulate placenta function via adiponectin.

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