Effect of short-term bromocriptine treatment on amniotic fluid prolactin concentration in the first half of pregnancy

1981 ◽  
Vol 97 (4) ◽  
pp. 559-561 ◽  
Author(s):  
P. Lehtovirta ◽  
T. Ranta
Keyword(s):  
Amniotic Fluid ◽  
Pregnant Women ◽  
Dopamine Receptors ◽  
Prolactin Level ◽  
Prolactin Secretion ◽  
Maternal Serum ◽  
Serum Prolactin ◽  
Fluid Level ◽  
Serum Prolactin Level ◽  
Short Term

Abstract. The effect of short-term bromocriptine treatment on amniotic fluid and maternal prolactin concentrations was studied in 9 pregnant women in the first half of pregnancy. Bromocriptine suppressed the maternal serum prolactin level, but had no effect on the amniotic fluid level. Since both foetal and maternal prolactin secretion are suppressed by bromocriptine our results suggest that amniotic fluid prolactin is produced by extrapituitary tissues, which do not contain dopamine receptors.

Danazol and prolactin status in patients with endometriosis

1984 ◽  
Vol 107 (4) ◽  
pp. 445-449 ◽  
Author(s):  
A. M. Wallace ◽  
D. A. R. Lees ◽  
A. D. G. Roberts ◽  
C. E. Gray ◽  
E. H. McLaren ◽  
...  
Keyword(s):  
Prolactin Level ◽  
Prolactin Secretion ◽  
Normal Serum ◽  
Serum Prolactin ◽  
Serum Prolactin Level ◽  
Significant Drop ◽  
Increased Sensitivity ◽  
Danazol Therapy

Abstract. A group of 55 women with endometriosis was studied before and during danazol therapy. An unexpectedly high proportion (36%) had a raised serum prolactin level before treatment which was reduced after 50 days of danazol (before treatment 783 ± 333 mU/l; on danazol 243 ± 113 mU/l, P < 0.001). In contrast patients with normal serum prolactin levels showed no significant drop on danazol therapy. In all patients serum oestradiol was significantly reduced during treatment (before treatment 449 ± 188 pmol/l; on danazol 207 ± 117 pmol/l, P < 0.001). In one patient with hyperprolactinaemia danazol reduced both basal and stimulated prolactin levels, whereas in 5 women with normal prolactin levels we could detect no gross alteration in metoclopramide or TRH stimulated prolactin levels associated with danazol therapy. The possibility that normalisation of raised prolactin levels may be secondary to reduced oestrogens and that patients with endometriosis have an increased sensitivity to oestrogen-induced prolactin secretion is discussed.

scholarly journals Association of Serum Prolactin Level with Preeclampsia

2021 ◽  
Vol 3 (5) ◽  
pp. 01-04
Author(s):  
Mesbah Uddin Ahmed ◽  
Saifun Nahar ◽  
Sheuly Ferdousi ◽  
Mohammad Monzurul Alam Bhuiyan ◽  
Amit Kumar Pramanik
Keyword(s):  
Pregnant Women ◽  
Prolactin Level ◽  
Rank Correlation ◽  
Serum Prolactin ◽  
Serum Prolactin Level ◽  
College Hospital ◽  
Positive Correlation ◽  
Spearman’S Rank Correlation ◽  
Spearman’S Rank Correlation Coefficient ◽  
The Difference

Introduction:Preeclampsia is a potentially fatal disorderof pregnant women; it remains an important cause of maternal mortality throughout the world. More than 50,000 maternal deaths occur worldwideeach year. Various researchers of different countries suggested an association of increase level of serumprolactin in preeclamptic patient. Estimation of serum prolactin level in pregnancy may be helpful in diagnosis of preeclampsia. Objective: Theobjective of the study is to observe the association of serum prolactin level with severity of preeclampsia. Materials and Methods: This cross-sectionalstudy was conducted from March 2020 to February 2021 in the Department of Laboratory Medicine, Department of Fetomaternal Medicine and Obstetrics and Gynecology, BSMMU and Dhaka Medical College Hospital, Dhaka. Fifty diagnosed patients of preeclampsia who fulfilled the inclusion and exclusioncriteria were selected as study population. At the same time 50 normal pregnant women were taken in another group. In both groups gestational age was calculated from last Menstrual date and confirmed by early ultrasound which wasdone at <14 weeks. Then serum prolactin level was calculated. Results: The mean serum prolactin level was 226.56±81.23 µg/L in mild and 394.53±78.75 µg/L in severe preeclampsia. The difference was statistically significant (p=0.001) between two groups.In ROC analysis cut off value of serum prolactin level was 118 μg/L.The area under curve (AUC) of serum prolactin was 0.923 (95% CI; 0.869-0.978). Spearman’s rank correlation coefficient test showed significant positive correlation (r=0.719,p=0.001) between serum prolactin level with severity of preeclampsia. This finding of the study revealed that serum prolactin level was increased with preeclampsia and was positive correlation with severity. Conclusion: Because of significantsensitivity and specificity, serum prolactin level maybe used as an important tool to diagnose preeclampsia and its severity.

scholarly journals Evaluation of maternal serum prolactin in pregnant women with gestational Diabetes mellitus

2021 ◽  
Vol 23 (10) ◽  
pp. 195-205
Author(s):  
Manal Matlab Hassan ◽  
◽  
Risala A. Ali ◽  
Keyword(s):  
Diabetes Mellitus ◽  
Glucose Metabolism ◽  
Pregnant Women ◽  
Normal Glucose Tolerance ◽  
Maternal Serum ◽  
Serum Prolactin ◽  
P Value ◽  
Serum Prolactin Level ◽  
Normal Glucose ◽  
The Mean

Maintenance of normal glucose metabolism during pregnancy is of particular importance. Prolactin may be a mediator in pathogenesis of impaired glucose metabolism. This study aimed to assess the levels of maternal serum prolactin in pregnant women with gestational Diabetes mellitus (GDM). This prospective observational study was done at AL– Emamain AL- Kadhemain Medical City/ Department of Obstetrics and Gynecology in Baghdad/ Iraq during the period from 1st March to 1st October 2018 on 150 pregnant women who were referred for OGTT for different indications. For all included women, maternal serum prolactin level and 75 gm OGTT was performed. The results showed that the mean±SD of maternal serum prolactin levels for all included women was (135.14±22.67) ng/ml and there was significantly negative correlation with (1hr) and (2hr) blood glucose levels of 75 gm OGTT at p value (0.027), (0.003) respectively. Out of 150 women included in the study (52) women diagnosed to have GDM and (98) women to have normal glucose tolerance. The mean±SD of maternal serum prolactin level was (123.6±13.7) ng/ml in GDM group which is significantly lower in comparison with mean ±SD (141.3±24.1) ng/ml in normal group at p value (0.0001). It can be concluded that women with GDM showed significantly lower serum prolactin levels in comparison with levels in women with normal glucose tolerance.

scholarly journals Comparison the Effect of Fennel on Maternal Serum Prolactin Level and Neonatal Weight Gain with Effect of Domperidon and Placebo

2020 ◽  
Vol 1 (4) ◽  
pp. 171-174
Author(s):  
A. Keshtkari ◽  
A. Mehboudi ◽  
M.A. Ghatee ◽  
N. Bagheri ◽  
◽  
...  
Keyword(s):  
Weight Gain ◽  
Prolactin Level ◽  
Maternal Serum ◽  
Serum Prolactin ◽  
Serum Prolactin Level

SERUM PROLACTINE LEVEL IN PATIENTS OF PSORIASIS VULGARIS AND ITS CORRELATION WITH DISEASE SEVERITY: A CASE-CONTROL STUDY

2019 ◽  
Vol 3 (6) ◽  
Author(s):  
Pawan Kumar Saini ◽  
Devendra Yadav ◽  
Rozy Badyal ◽  
Suresh Jain ◽  
Arti Singh ◽  
...  
Keyword(s):  
Disease Severity ◽  
Prolactin Level ◽  
Case Control Study ◽  
Statistical Significance ◽  
Case Control ◽  
Serum Prolactin ◽  
P Value ◽  
Serum Prolactin Level ◽  
R Value ◽  
Control Study

Background: Psoriasis is an autoimmune chronic inflammatory disorder affecting the skin mediated by T-lymphocytes resulting in production of cytokines which cause hyperproliferation of keratinocytes.  Several factors and hormones like Prolactin have an action similar to these cytokines in promoting the multiplication of keratinocytes and other cells like lymphocytes and epithelial cells may have a role on the etiopathogenesis of psoriasis. Aim:-The aim of study is to compare the serum Prolactin levels in patients of psoriasis with a control group. Setting and study design: This is a case-control study conducted in the department of Dermatology, Venereology and Leprosy GMC, Kota over a period of 1year from July 2017 to June 2018 Material and method: The study included 100 cases of psoriasis (60 males and 40 females) and 100 controls similar for age and sex. Serum Prolactin levels were measured by ECLIA and results were obtained. Statistical analysis: Mean and standard deviation were calculated for each variable. Statistical significance of the results was analyzed using correlation analysis (Pearson correlation coefficient) and independent samples t-test. Statistical significance was assumed at p value<0.05. Result: Serum Prolactin level was significantly higher in cases of psoriasis compared to controls (p-value <0.001). PASI score and serum Prolactin levels were found to have a positive correlation (r value = 0.337; p-value: 0.001). No significant  correlation was found between serum levels of Prolactin and duration of disease r value= -0.034, P value =0.733). Serum Prolactin level was higher in male patients compared to females patients. Conclusion:- High serum Prolactin may be a biological marker of disease severity in psoriasis and may have a role in the pathogenesis of psoriasis. Further studies with large sample size are required to confirm this hypothesis.

Fawzy M. Khalila ,Serum prolactin level as a biological marker of severity in liver cirrhosis.

2017 ◽  
Vol 34 (2) ◽  
pp. 140-145
Author(s):  
Fawzy M. Khalil ◽  
Mohamed A. Elassal ◽  
Ahmed M. Hussein ◽  
Mahmoud Rizk ◽  
Mohamed A. Awadein ◽  
...  
Keyword(s):  
Liver Cirrhosis ◽  
Prolactin Level ◽  
Biological Marker ◽  
Serum Prolactin ◽  
Serum Prolactin Level

scholarly journals The association between serum prolactin levels and interleukin-6 and systemic lupus erythematosus activity

Reumatismo ◽  
2018 ◽  
Vol 70 (4) ◽  
pp. 241-250 ◽  
Author(s):  
W.A. Wan Asyraf ◽  
M.S. Mohd Shahrir ◽  
W. Asrul ◽  
A.W. Norasyikin ◽  
O. Hanita ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Nephritis ◽  
Disease Activity ◽  
Lupus Erythematosus ◽  
Prolactin Level ◽  
Serum Prolactin ◽  
Systemic Lupus ◽  
Serum Prolactin Level ◽  
Active Lupus Nephritis ◽  
Active Lupus

Based on the recent evidence of association between hyperprolactinemia and systemic lupus erythematosus disease activity (SLEDAI), a study was conducted to analyze the association of hyperprolactinemia with lupus nephritis disease activity. In this cross-sectional study, the analysis was conducted on SLE patients who visited the University Kebangsaan Malaysia Medical Centre (UKMMC) Nephrology Clinic from August 2015 till February 2016. The disease activity was measured using the SLEDAI score, with more than 4 indicating active lupus nephritis. Basal resting prolactin level was analyzed in 43 patients with lupus nephritis, in 27.9% of them had raised serum prolactin. The median of serum prolactin level at 0 minutes was 19.91 ng/mL (IQR: 15.95-22.65 ng/ mL) for active lupus nephritis, which was significantly higher compared to the median of serum prolactin level of 14.34 ng/mL (IQR: 11.09-18.70 ng/mL) for patients in remission (p=0.014). The serum prolactin level positively correlated with SLEDAI (rhos: 0.449, p=0.003) and the UPCI level in lupus nephritis patients (rhos: 0.241, p=0.032). The results were reproduced when the serum prolactin was repeated after 30 minutes. However, the serum prolactin levels at 0 minutes were higher than those taken after 30 minutes (p=0.001). An assessment of serum IL-6 levels found that the active lupus nephritis patients had a higher median level of 65.91 pg/ mL (IQR: 21.96-146.14 pg/mL) compared to the in-remission level of 15.84 pg/mL (IQR: 8.38-92.84 pg/mL), (p=0.039). Further correlation analysis revealed that there was no statistical correlation between the interleukin (IL)-6 levels with serum prolactin, SLEDAI and other lupus nephritis parameters. An ROC curve analysis of serum prolactin at 0 minutes and serum prolactin after 30 minutes and IL-6 levels for prediction of SLE disease activity provided the cutoff value of serum prolactin at 0 minutes, which was 14.63 ng/mL with a sensitivity of 91.7% and specificity of 58.1% and AUC of 0.74 (p=0.015). This study concurred with the previous findings that stated that hyperprolactinemia is prevalent in SLE patients and correlated with clinical disease activity and UPCI level. The baseline of the fasting serum prolactin level was found to be a sensitive biomarker for the evaluation of lupus nephritis disease activity.

scholarly journals Forbes albright syndrome: galactorrhea–amenorrhea associated with a pituitary tumour: a case report

2021 ◽  
Vol 8 (1) ◽  
pp. 27-29
Author(s):  
Rupak Chatterjee ◽  
Prantiki Halder ◽  
Sudeshna Mallik ◽  
Bibhuti Saha
Keyword(s):  
Case Report ◽  
Prolactin Level ◽  
Pituitary Tumour ◽  
Serum Prolactin ◽  
Loss Of Consciousness ◽  
Pituitary Macroadenoma ◽  
Serum Prolactin Level ◽  
Mri Brain ◽  
Menstrual Irregularities ◽  
Albright Syndrome

Forbes Albright syndrome is a hyperprolactinemia syndrome characterised by galactorrhea and amenorrhea associated with a pituitary tumour. Here we report a case of 30 years female who was admitted with menstrual irregularities for 4 months, galatorrhea and headache with recurrent episodes of loss of consciousness for 3months. Her serum prolactin level was highly raised. MRI brain (plain plus contrast) showed enlarged pituitary gland- pituitary macroadenoma. She was diagnosed as a case of Forbes Albright Syndrome and was treated with Tablet Cabergoline. With the medication, size of her tumour markedly reduced and symptoms resolved as she was followed up after 3 months.

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