scholarly journals Bone Marrow Derived Kit-positive Cells Colonize the Gut but Fail to Restore Pacemaker Function in Intestines Lacking Interstitial Cells of Cajal

2014 ◽  
Vol 20 (3) ◽  
pp. 326-337 ◽  
Author(s):  
Conor J McCann ◽  
Sung-Jin Hwang ◽  
Grant W Hennig ◽  
Sean M Ward ◽  
Kenton M Sanders
Keyword(s):  
Bone Marrow ◽  
Interstitial Cells Of Cajal ◽  
Interstitial Cells ◽  
Pacemaker Function ◽  
Cells Of Cajal

Nitric oxide-induced oxidative stress impairs pacemaker function of murine interstitial cells of Cajal during inflammation

2016 ◽  
Vol 111 ◽  
pp. 838-848 ◽  
Author(s):  
Noriyuki Kaji ◽  
Kazuhide Horiguchi ◽  
Satoshi Iino ◽  
Shinsuke Nakayama ◽  
Tomohiko Ohwada ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Nitric Oxide ◽  
Interstitial Cells Of Cajal ◽  
Interstitial Cells ◽  
Pacemaker Function ◽  
Cells Of Cajal

scholarly journals Homing of the Bone Marrow-Derived Interstitial Cells of Cajal is Decreased in Diabetic Mouse Intestine

2011 ◽  
Vol 26 (6) ◽  
pp. 1072-1078 ◽  
Author(s):  
Yimin Li ◽  
Hideto Kojima ◽  
Kazunori Fujino ◽  
Kazuhiro Matsumura ◽  
Miwako Katagi ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Interstitial Cells Of Cajal ◽  
Diabetic Mouse ◽  
Interstitial Cells ◽  
Mouse Intestine ◽  
Cells Of Cajal

712 Bone-Marrow Cells Are Able to Develop Interstitial Cells of Cajal: Morphologic Evidences in W/WV Mice

2008 ◽  
Vol 134 (4) ◽  
pp. A-101
Author(s):  
Shuji Ishii ◽  
Shingo Tsuji ◽  
Masahiko Tsujii ◽  
Jumpei Kondo ◽  
Sachiko Nakajima ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Interstitial Cells Of Cajal ◽  
Bone Marrow Cells ◽  
Interstitial Cells ◽  
Cells Of Cajal ◽  
Marrow Cells

scholarly journals Pacemaker function and neural responsiveness of subserosal interstitial cells of Cajal in the mouse colon

2020 ◽  
Vol 598 (4) ◽  
pp. 651-681 ◽  
Author(s):  
Bernard T. Drumm ◽  
Benjamin E. Rembetski ◽  
Katelyn Messersmith ◽  
Marena S. Manierka ◽  
Salah A. Baker ◽  
...  
Keyword(s):  
Interstitial Cells Of Cajal ◽  
Interstitial Cells ◽  
Mouse Colon ◽  
Pacemaker Function ◽  
Cells Of Cajal

scholarly journals Electroacupuncture at ST36 Increases Bone Marrow-Derived Interstitial Cells of Cajal via the SDF-1/CXCR4 and mSCF/Kit-ETV1 Pathways in the Stomach of Diabetic Mice

2018 ◽  
Vol 2018 ◽  
pp. 1-14
Author(s):  
Jiao Zhao ◽  
Jing An ◽  
Shi Liu
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Transplantation ◽  
High Frequency ◽  
Interstitial Cells Of Cajal ◽  
Low Frequency ◽  
Interstitial Cells ◽  
Diabetic Mice ◽  
Protein Levels ◽  
Qrt Pcr ◽  
Cells Of Cajal

Background. The loss of interstitial cells of Cajal (ICC) is observed in diabetic gastroparesis. Electroacupuncture (EA) maintains ICC networks, but the effects and mechanisms of EA on ICC of bone marrow derivation in the stomach have not been investigated. Methods. C57BL/6 mice were randomized into six groups: control, diabetic (DM), bone marrow transplantation (BMT) + DM, BMT + DM + sham EA (SEA), BMT + DM + low-frequency EA (LEA), and BMT + DM + high-frequency (HEA). c-Kit+GFP+ cells in the stomach were detected by immunofluorescence staining. Western blotting and qRT-PCR were employed to determine c-Kit, GFP, SDF-1, CXCR4, mSCF, pERK, and ETV1 expression. Results. (1) c-Kit+GFP+ cells were elevated in the BMT + DM + LEA and HEA groups. (2) The mRNA and protein levels of GFP, SDF-1, and CXCR4 were increased in the BMT + DM + LEA and BMT + DM + HEA groups. (3) The mRNA and protein levels of mSCF, c-Kit, pERK, and ETV1 were significantly reduced in the DM group but markedly elevated in the BMT + DM + LEA and HEA groups. Conclusion. EA at ST36 increases bone marrow-derived ICC in the stomach of diabetic mice via the SDF-1/CXCR4 and mSCF/c-Kit-ETV1 pathways.

scholarly journals Bone Marrow Derivation of Interstitial Cells of Cajal in Small Intestine Following Intestinal Injury

2010 ◽  
Vol 2010 ◽  
pp. 1-9 ◽  
Author(s):  
Dengqun Liu ◽  
Fengchao Wang ◽  
Zhongmin Zou ◽  
Shiwu Dong ◽  
Junping Wang ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Small Intestine ◽  
Gastrointestinal Tract ◽  
Myenteric Plexus ◽  
Interstitial Cells Of Cajal ◽  
Mononuclear Cells ◽  
Interstitial Cells ◽  
Positive Staining ◽  
Alternative Source ◽  
Cells Of Cajal

Interstitial cells of Cajal (ICCs) in gastrointestinal tract are specialized cells serving as pacemaker cells. The origin of ICCs is currently not fully characterized. In this work, we aimed to study whether bone marrow-derived cells (BMDCs) could contribute to the origin of ICCs in the muscular plexus of small intestine using GFP-C57BL/6 chimeric mice.Engraftment of BMDCs in the intestine was investigated for GFP expression. GFP positive bone marrow mononuclear cells reached a proportion of95.65%±3.72%at different times in chimerism. Donor-derived cells distributed widely in all the layers of the gastrointestinal tract. There were GFP positive BMDCs in the myenteric plexus, which resembled characteristics of ICCs, including myenteric location, c-Kit positive staining, and ramified morphology. Donor-derived ICCs in the myenteric plexus contributed to a percentage ranging9.25%±4.9%of all the ICCs in the myenteric plexus. In conclusion, here we described that donor-derived BMDCs might differentiate into gastrointestinal ICCs after radiation injury, which provided an alternative source for the origin of the ICCs in the muscular plexus of adult intestine. These results further identified the plasticity of BMDCs and indicated therapeutic implications of BMDCs for the gastrointestinal dysmotility caused by ICCs disorders.

Sodium current in human small intestinal interstitial cells of cajal

2001 ◽  
Vol 120 (5) ◽  
pp. A201-A201 ◽  
Author(s):  
P STREGE ◽  
A RICH ◽  
Y OU ◽  
S GIBBONS ◽  
M SARR ◽  
...  
Keyword(s):  
Interstitial Cells Of Cajal ◽  
Sodium Current ◽  
Interstitial Cells ◽  
Small Intestinal ◽  
Cells Of Cajal
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