Comparative Study of PCNA and Ki-67 Immunohistochemical Staining in Psoriasis, Basal Cell Carcinomas

1994 ◽  
Vol 6 (2) ◽  
pp. 146
Author(s):  
Mi Jung Jung ◽  
Young-Keun Kim
Keyword(s):  
Comparative Study ◽  
Basal Cell ◽  
Immunohistochemical Staining ◽  
Ki 67 ◽  
Basal Cell Carcinomas

scholarly journals Expression of retinoic acid receptor proteins in basal cell carcinomas: an immunohistochemical analysis.

1996 ◽  
Vol 44 (12) ◽  
pp. 1415-1420 ◽  
Author(s):  
J Kamradt ◽  
J Reichrath
Keyword(s):  
Retinoic Acid ◽  
Basal Cell ◽  
Retinoic Acid Receptor ◽  
Immunohistochemical Analysis ◽  
Ki 67 ◽  
Weak Staining ◽  
Basal Cell Carcinomas ◽  
Acid Metabolites ◽  
Peripheral Cells ◽  
Labeling Pattern

We analyzed immunohistochemically the expression of RAR proteins in basal cell carcinomas (BCCs; n = 15) in situ. The labeling pattern for the different types of RARs was compared with the staining pattern of the proliferation marker Ki-67 in the same tumors. We found strong immunoreactivity for RAR-alpha and moderate immunoreactivity for RAR-gamma in all BCCs analyzed, whereas no or very weak staining for RAR-beta protein was detected. In contrast to RAR-gamma, which revealed no or only marginal differences in staining intensities, RAR-alpha immunoreactivity was consistently stronger in BCCs compared to adjacent unaffected epidermis. In general, labeling of BCCs for RAR-alpha and RAR-gamma was pronounced in cells of the palisade and peripheral cells, whereas staining in the center of the tumors was heterogeneous. Eleven of the 15 BCCs analyzed revealed no visual correlation in comparing labeling patterns for RAR-alpha and RAR-gamma with the labeling pattern for Ki-67. In four specimens, expression of RAR-alpha, RAR-gamma, and Ki-67 proteins was confined to peripheral tumor cells. Our findings indicate that (a) RAR-alpha and RAR-gamma proteins are, in contrast to RAR-beta, strongly expressed in BCCs; (b) expression of RAR-alpha is upregulated in BCCs compared to keratinocytes of uninvolved epidermis; and (c) BCCs may be targets for potentially preventive or therapeutic treatment with RAR-alpha- or RAR-gamma-selective retinoic acid metabolites.

scholarly journals Superficial Type of Multiple Basal Cell Carcinomas: Detailed Comparative Study of Its Dermoscopic and Histopathological Findings

2011 ◽  
Vol 2011 ◽  
pp. 1-4 ◽  
Author(s):  
Akiko Hirofuji ◽  
Kojiro Takiguchi ◽  
Koichiro Nakamura ◽  
Akira Kuramochi ◽  
Tetsuya Tsuchida ◽  
...  
Keyword(s):  
Comparative Study ◽  
Cross Section ◽  
Basal Cell ◽  
Histopathological Findings ◽  
Multiple Lesions ◽  
Basal Cell Carcinomas ◽  
Lateral Connection ◽  
Superficial Type ◽  
Multiple Basal Cell Carcinomas ◽  
Black Color

We investigated in detail the dermoscopic and histopathological findings in a case of a superficial type of multiple basal cell carcinomas (BCCs). These multiple lesions (occurring in the chest, neck, and back) showed three different findings, respectively. Dermoscopy of the erythematous and brown-colored patch on the anterior chest showed spoke wheel areas, and the histopathological cross-section revealed vertical spoke wheel structures. In the black- and brown-colored patch at the neck, the dermatoscopy showed a maple leaf-like structure, which was in accordance with the strengthening of the histological lateral connection of the lesion. The brown-colored patch of the lateral back histologically showed irregularly enlarged spoke wheel-like areas with peripheral increased melanin pigments, which correlated with the dark black color of dermoscopic maple leaf-like areas. The vertical spoke wheel areas by dermatoscopy revealed a horizontal spoke wheel structure by histopathology.

Ki-67 antigen expression and growth pattern of basal cell carcinomas

1993 ◽  
Vol 285 (5) ◽  
pp. 291-295 ◽  
Author(s):  
H. -P. Baum ◽  
I. Meurer ◽  
G. Unteregger
Keyword(s):  
Basal Cell ◽  
Growth Pattern ◽  
Antigen Expression ◽  
Ki 67 ◽  
Basal Cell Carcinomas

Comparison of PTCH1, COX-2, p53, and Ki-67 protein expression in basal cell carcinomas of nodular and superficial subtypes arising on the head and trunk

2016 ◽  
Vol 55 (10) ◽  
pp. 1096-1105 ◽  
Author(s):  
Mohammad Khalesi ◽  
Mary Waterhouse ◽  
David C. Whiteman ◽  
Richard Johns ◽  
Cliff Rosendahl ◽  
...  
Keyword(s):  
Protein Expression ◽  
Basal Cell ◽  
Ki 67 ◽  
Basal Cell Carcinomas ◽  
Cox 2

Scalpel excision of basal cell carcinomas

1978 ◽  
Vol 114 (5) ◽  
pp. 739-742 ◽  
Author(s):  
R. S. Bart
Keyword(s):  
Basal Cell ◽  
Basal Cell Carcinomas
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