Comparison of PTCH1, COX-2, p53, and Ki-67 protein expression in basal cell carcinomas of nodular and superficial subtypes arising on the head and trunk

2016 ◽  
Vol 55 (10) ◽  
pp. 1096-1105 ◽  
Author(s):  
Mohammad Khalesi ◽  
Mary Waterhouse ◽  
David C. Whiteman ◽  
Richard Johns ◽  
Cliff Rosendahl ◽  
...  
Keyword(s):  
Protein Expression ◽  
Basal Cell ◽  
Ki 67 ◽  
Basal Cell Carcinomas ◽  
Cox 2

scholarly journals Expression of retinoic acid receptor proteins in basal cell carcinomas: an immunohistochemical analysis.

1996 ◽  
Vol 44 (12) ◽  
pp. 1415-1420 ◽  
Author(s):  
J Kamradt ◽  
J Reichrath
Keyword(s):  
Retinoic Acid ◽  
Basal Cell ◽  
Retinoic Acid Receptor ◽  
Immunohistochemical Analysis ◽  
Ki 67 ◽  
Weak Staining ◽  
Basal Cell Carcinomas ◽  
Acid Metabolites ◽  
Peripheral Cells ◽  
Labeling Pattern

We analyzed immunohistochemically the expression of RAR proteins in basal cell carcinomas (BCCs; n = 15) in situ. The labeling pattern for the different types of RARs was compared with the staining pattern of the proliferation marker Ki-67 in the same tumors. We found strong immunoreactivity for RAR-alpha and moderate immunoreactivity for RAR-gamma in all BCCs analyzed, whereas no or very weak staining for RAR-beta protein was detected. In contrast to RAR-gamma, which revealed no or only marginal differences in staining intensities, RAR-alpha immunoreactivity was consistently stronger in BCCs compared to adjacent unaffected epidermis. In general, labeling of BCCs for RAR-alpha and RAR-gamma was pronounced in cells of the palisade and peripheral cells, whereas staining in the center of the tumors was heterogeneous. Eleven of the 15 BCCs analyzed revealed no visual correlation in comparing labeling patterns for RAR-alpha and RAR-gamma with the labeling pattern for Ki-67. In four specimens, expression of RAR-alpha, RAR-gamma, and Ki-67 proteins was confined to peripheral tumor cells. Our findings indicate that (a) RAR-alpha and RAR-gamma proteins are, in contrast to RAR-beta, strongly expressed in BCCs; (b) expression of RAR-alpha is upregulated in BCCs compared to keratinocytes of uninvolved epidermis; and (c) BCCs may be targets for potentially preventive or therapeutic treatment with RAR-alpha- or RAR-gamma-selective retinoic acid metabolites.

p53 protein expression in basal cell carcinomas

1992 ◽  
Vol 21 (6) ◽  
pp. 579-581 ◽  
Author(s):  
M. BARBARESCHI ◽  
S. GIRLANDO ◽  
P. CRISTOFOLINI ◽  
M. CRISTOFOLINI ◽  
R. TOGNI ◽  
...  
Keyword(s):  
Protein Expression ◽  
Basal Cell ◽  
P53 Protein ◽  
P53 Protein Expression ◽  
Basal Cell Carcinomas

Ki-67 antigen expression and growth pattern of basal cell carcinomas

1993 ◽  
Vol 285 (5) ◽  
pp. 291-295 ◽  
Author(s):  
H. -P. Baum ◽  
I. Meurer ◽  
G. Unteregger
Keyword(s):  
Basal Cell ◽  
Growth Pattern ◽  
Antigen Expression ◽  
Ki 67 ◽  
Basal Cell Carcinomas

B-Raf Mutations, Microsatellite Instability and p53 Protein Expression in Sporadic Basal Cell Carcinomas

2011 ◽  
Vol 17 (3) ◽  
pp. 633-637 ◽  
Author(s):  
Angeliki Stamatelli ◽  
Angelica A. Saetta ◽  
Thaleia Bei ◽  
Nicolaos Kavantzas ◽  
Nicolaos V. Michalopoulos ◽  
...  
Keyword(s):  
Protein Expression ◽  
Microsatellite Instability ◽  
Basal Cell ◽  
P53 Protein ◽  
P53 Protein Expression ◽  
Basal Cell Carcinomas

bcl-2 protein expression in aggressive and non-aggressive basal cell carcinomas

2000 ◽  
Vol 27 (6) ◽  
pp. 283-291 ◽  
Author(s):  
Pratistadevi K. Ramdial ◽  
Anil Madaree ◽  
Roshilla Reddy ◽  
Runjan Chetty
Keyword(s):  
Protein Expression ◽  
Basal Cell ◽  
Basal Cell Carcinomas

Scalpel excision of basal cell carcinomas

1978 ◽  
Vol 114 (5) ◽  
pp. 739-742 ◽  
Author(s):  
R. S. Bart
Keyword(s):  
Basal Cell ◽  
Basal Cell Carcinomas
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