Ki-67 antigen expression and growth pattern of basal cell carcinomas

1993 ◽  
Vol 285 (5) ◽  
pp. 291-295 ◽  
Author(s):  
H. -P. Baum ◽  
I. Meurer ◽  
G. Unteregger
Keyword(s):  
Basal Cell ◽  
Growth Pattern ◽  
Antigen Expression ◽  
Ki 67 ◽  
Basal Cell Carcinomas

Prognostic value of Ki67 antigen expression in basal cell carcinomas

2006 ◽  
Vol 133 (5) ◽  
pp. 737-741 ◽  
Author(s):  
E. HEALY ◽  
B. ANGUS ◽  
C.M. LAWRENCK ◽  
J.L. REES
Keyword(s):  
Basal Cell ◽  
Prognostic Value ◽  
Antigen Expression ◽  
Ki67 Antigen ◽  
Basal Cell Carcinomas

scholarly journals Expression of retinoic acid receptor proteins in basal cell carcinomas: an immunohistochemical analysis.

1996 ◽  
Vol 44 (12) ◽  
pp. 1415-1420 ◽  
Author(s):  
J Kamradt ◽  
J Reichrath
Keyword(s):  
Retinoic Acid ◽  
Basal Cell ◽  
Retinoic Acid Receptor ◽  
Immunohistochemical Analysis ◽  
Ki 67 ◽  
Weak Staining ◽  
Basal Cell Carcinomas ◽  
Acid Metabolites ◽  
Peripheral Cells ◽  
Labeling Pattern

We analyzed immunohistochemically the expression of RAR proteins in basal cell carcinomas (BCCs; n = 15) in situ. The labeling pattern for the different types of RARs was compared with the staining pattern of the proliferation marker Ki-67 in the same tumors. We found strong immunoreactivity for RAR-alpha and moderate immunoreactivity for RAR-gamma in all BCCs analyzed, whereas no or very weak staining for RAR-beta protein was detected. In contrast to RAR-gamma, which revealed no or only marginal differences in staining intensities, RAR-alpha immunoreactivity was consistently stronger in BCCs compared to adjacent unaffected epidermis. In general, labeling of BCCs for RAR-alpha and RAR-gamma was pronounced in cells of the palisade and peripheral cells, whereas staining in the center of the tumors was heterogeneous. Eleven of the 15 BCCs analyzed revealed no visual correlation in comparing labeling patterns for RAR-alpha and RAR-gamma with the labeling pattern for Ki-67. In four specimens, expression of RAR-alpha, RAR-gamma, and Ki-67 proteins was confined to peripheral tumor cells. Our findings indicate that (a) RAR-alpha and RAR-gamma proteins are, in contrast to RAR-beta, strongly expressed in BCCs; (b) expression of RAR-alpha is upregulated in BCCs compared to keratinocytes of uninvolved epidermis; and (c) BCCs may be targets for potentially preventive or therapeutic treatment with RAR-alpha- or RAR-gamma-selective retinoic acid metabolites.

Comparison of PTCH1, COX-2, p53, and Ki-67 protein expression in basal cell carcinomas of nodular and superficial subtypes arising on the head and trunk

2016 ◽  
Vol 55 (10) ◽  
pp. 1096-1105 ◽  
Author(s):  
Mohammad Khalesi ◽  
Mary Waterhouse ◽  
David C. Whiteman ◽  
Richard Johns ◽  
Cliff Rosendahl ◽  
...  
Keyword(s):  
Protein Expression ◽  
Basal Cell ◽  
Ki 67 ◽  
Basal Cell Carcinomas ◽  
Cox 2

scholarly journals TERTp mutations and p53 expression in head and neck cutaneous basal cell carcinomas with different aggressive features

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
António Castanheira ◽  
Maria João Vieira ◽  
Mafalda Pinto ◽  
Carolina Dias ◽  
Luísa Prada ◽  
...  
Keyword(s):  
Head And Neck ◽  
Basal Cell ◽  
Growth Pattern ◽  
P53 Protein ◽  
Tertiary Hospital ◽  
P53 Overexpression ◽  
P53 Expression ◽  
Mutation Status ◽  
Basal Cell Carcinomas

AbstractCutaneous basal cell carcinoma (cBCC) is an economic burden to health services, due to its great morbidity and increasing incidence in old people. Infiltrative cBCCs and cBCCs with micronodular pattern are considered as more aggressive. The role of p53 expression and TERTp mutation on cBCC behavior remains to be clarified. We aimed to assess TERTp mutations and p53 expression in relation to the cBCC histological subtype in a cohort of patients referred to an ENT Department of a tertiary Hospital of Northern Portugal. We performed a retrospective clinicopathological and histological review of the head and neck cBCCs followed-up at the otorhinolaryngology department of Trás-os-Montes e Alto Douro hospital (January 2007–June 2018). We assessed TERTp mutations in 142 cBCCs and p53 protein expression, through immunohistochemistry, in 157 cBCCs. We detected TERTp mutations in 43.7% of cBCCs and p53 overexpression in 60.5% of cBCCs. We spotted association of p53 overexpression and TERTp mutation with necrosis. In the infitrative-growth pattern cBCCs, there was no significant association with the clinical and histological features evaluated, except for necrosis. In the indolent-growth cBCCs, we identified a significant association of TERTp mutation status with female sex, necrosis, multiple cBCCs, and p53 positive expression. Our results suggest that TERTp mutation may be useful to identify more aggressive features in the indolent-growth pattern cBCCs (nodular and superficial subtypes). Further studies with larger cohorts are warranted to clarify the relevance of TERTp mutation in cBCCs.

Scalpel excision of basal cell carcinomas

1978 ◽  
Vol 114 (5) ◽  
pp. 739-742 ◽  
Author(s):  
R. S. Bart
Keyword(s):  
Basal Cell ◽  
Basal Cell Carcinomas
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