Drug Therapy and Literature Review of Low dose Methotrexate in the Treatment of Bone Marrow Suppression due to Ectopic Pregnancy

2012 ◽  
Keyword(s):  
Bone Marrow ◽  
Drug Therapy ◽  
Literature Review ◽  
Ectopic Pregnancy ◽  
Low Dose ◽  
Bone Marrow Suppression ◽  
Dose Methotrexate

scholarly journals Severe bone marrow suppression following single-dose methotrexate treatment for ectopic pregnancy

2017 ◽  
Author(s):  
Betül Dündar ◽  
Burcu Dinçgez Çakmak ◽  
Gülten Özgen ◽  
Fatma Ketenci Gencer ◽  
Burcu Aydın Boyama
Keyword(s):  
Bone Marrow ◽  
Single Dose ◽  
Ectopic Pregnancy ◽  
Bone Marrow Suppression ◽  
Dose Methotrexate ◽  
Methotrexate Treatment

scholarly journals Acute Methotrexate Toxicity: A Fatal Condition in Two Cases of Psoriasis

2014 ◽  
Vol 2014 ◽  
pp. 1-3 ◽  
Author(s):  
Pankti Jariwala ◽  
Vinay Kumar ◽  
Khyati Kothari ◽  
Sejal Thakkar ◽  
Dipak Dayabhai Umrigar
Keyword(s):  
Bone Marrow ◽  
Drug Interactions ◽  
Creatinine Level ◽  
Joint Pain ◽  
Low Dose ◽  
Skin Lesions ◽  
Bone Marrow Suppression ◽  
Intermittent Treatment ◽  
Self Medication ◽  
Dose Methotrexate

We describe two fatal cases of low dose methotrexate (MTX) toxicity in patients with psoriasis, emphasizing the factors that exacerbate MTX toxicity. The first patient was a 50-year-old male of psoriasis on intermittent treatment with MTX. After a treatment-free period of six months, he had self-medication of MTX along with analgesic for joint pain for one week which followed ulceration of the lesions, bone marrow suppression, and eventually death. The second patient was a 37-year-old male of psoriasis, who has taken MTX one week earlier without prior investigations. He had painful ulcerated skin lesions and bone marrow suppression. On investigations, he showed high creatinine level and atrophied, nonfunctioning right kidney on ultrasonography. In spite of dialysis, he succumbed to death. MTX is safe and effective if monitored properly, but inadvertent use may lead to even death also. Prior workup and proper counseling regarding the drug interactions as well as self-medication should be enforced.

scholarly journals Acute methotrexate toxicity in psoriasis

2019 ◽  
Vol 5 (3) ◽  
pp. 652
Author(s):  
Peram Karunakar ◽  
Venkateswara Rao Garimella ◽  
Chinmai Yerram ◽  
Anusha Gogula
Keyword(s):  
Bone Marrow ◽  
Plaque Psoriasis ◽  
Low Dose ◽  
Standard Treatment ◽  
Treatment Guidelines ◽  
Psoriasis Patient ◽  
Bone Marrow Suppression ◽  
Chronic Plaque Psoriasis ◽  
Dose Methotrexate ◽  
Standard Treatment Guidelines

<p align="left">We describe two cases of low dose methotrexate (MTX) toxicity in patients with psoriasis. Patient was a 49-year-old male, known case of chronic plaque psoriasis from 10 years on and off. He was advised to take MTX 2.5 mg 2 days a week but patient took 2.5 mg twice daily (BD) for 6 continuous days following which he developed ulceration over psoriatic plaques and bone marrow suppression. MTX is safe and effective if adhered to standard treatment guidelines but inadverent use may lead to it’s toxicity.</p>

Low-dose methotrexate treatment in ectopic pregnancy: a retrospective analysis of 164 ectopic pregnancies treated between 2000 and 2008

2013 ◽  
Vol 289 (2) ◽  
pp. 329-335 ◽  
Author(s):  
Johannes Lermann ◽  
Petra Segl ◽  
Sebastian M. Jud ◽  
Matthias W. Beckmann ◽  
Peter Oppelt ◽  
...  
Keyword(s):  
Ectopic Pregnancy ◽  
Retrospective Analysis ◽  
Low Dose ◽  
Dose Methotrexate ◽  
Methotrexate Treatment ◽  
Ectopic Pregnancies
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