Experience with low-dose methotrexate: Toxicity, tolerability and effect on conventional patterns of drug therapy for inflammatory arthritis

1995 ◽  
Vol 14 (5) ◽  
pp. 544-550 ◽  
Author(s):  
M. Nisar ◽  
L. Carlisle ◽  
R. Amos
Keyword(s):  
Drug Therapy ◽  
Inflammatory Arthritis ◽  
Low Dose ◽  
Dose Methotrexate ◽  
Methotrexate Toxicity

scholarly journals Low-dose methotrexate toxicity

2019 ◽  
Vol 191 (15) ◽  
pp. E423-E423 ◽  
Author(s):  
Kevin Pivovarov ◽  
Jonathan S. Zipursky
Keyword(s):  
Low Dose ◽  
Dose Methotrexate ◽  
Methotrexate Toxicity

scholarly journals Low Dose Methotrexate Toxicity Leading to Death in the Intensive Care Unit

2019 ◽  
Vol 4 (4) ◽  
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Low Dose ◽  
Low Doses ◽  
Dose Methotrexate ◽  
Methotrexate Toxicity ◽  
Severe Pancytopenia

Methotrexate toxicity has been widely shown to cause myelosuppression but the literature demonstrating low doses of the drug causing the same issue is much scarcer. Our patient presented with severe pancytopenia which began to improve with treatment but she ultimately succumbed to a superimposed pneumonia.

Clinical characteristics and risk factors for low dose methotrexate toxicity: A cohort of 28 patients

2014 ◽  
Vol 13 (11) ◽  
pp. 1109-1113 ◽  
Author(s):  
Shaye Kivity ◽  
Yaron Zafrir ◽  
Ronen Loebstein ◽  
Rachel Pauzner ◽  
Meir Mouallem ◽  
...  
Keyword(s):  
Risk Factors ◽  
Clinical Characteristics ◽  
Low Dose ◽  
Dose Methotrexate ◽  
Methotrexate Toxicity

scholarly journals Potential contributors to low dose methotrexate toxicity in a patient with rheumatoid arthritis and pernicious anemia: case report

2021 ◽  
Vol 5 (1) ◽  
Author(s):  
Miguel A. Jara-Palacios ◽  
William Chun ◽  
Nomi L. Traub
Keyword(s):  
Rheumatoid Arthritis ◽  
Vitamin B12 ◽  
Pernicious Anemia ◽  
Low Dose ◽  
Macrocytic Anemia ◽  
Vitamin B12 Deficiency ◽  
Multiple Factors ◽  
Dose Methotrexate ◽  
Methotrexate Toxicity ◽  
B12 Deficiency

Abstract Background Low dose methotrexate toxicity rarely occurs, but may present with severe complications, such as pancytopenia, hepatotoxicity, mucositis, and pneumonitis. Known risk factors for methotrexate toxicity include dosing errors, metabolic syndrome, hypoalbuminemia, renal dysfunction, lack of folate supplementation, and the concomitant use of drugs that interfere with methotrexate metabolism. Vitamin B12 deficiency leads to megaloblastic anemia and may cause pancytopenia, but its role in methotrexate toxicity has not been described. Case presentation We present a case of a patient with rheumatoid arthritis who was admitted with febrile neutropenia, pancytopenia, and severe mucositis, likely secondary to low dose methotrexate toxicity. She had multiple factors that potentially contributed to the development of toxicity, including concurrent sulfasalazine use for rheumatoid arthritis. An evaluation of the patient’s macrocytic anemia revealed pernicious anemia. The patient’s illness resolved with cessation of methotrexate and sulfasalazine, leucovorin treatment and vitamin B12 repletion. Conclusions This case illustrates the multiple factors that may potentially contribute to low dose methotrexate toxicity and highlights the importance of testing for vitamin B12 deficiency in rheumatoid arthritis patients with macrocytic anemia. Addressing all the modifiable factors that potentially contribute to low dose methotrexate toxicity may improve outcomes.

A CASE OF LOW DOSE METHOTREXATE TOXICITY CAUSING PANCYTOPENIA

CHEST Journal ◽  
2019 ◽  
Vol 155 (4) ◽  
pp. 100A ◽  
Author(s):  
W. Grist ◽  
Y. Elamir
Keyword(s):  
Low Dose ◽  
Dose Methotrexate ◽  
Methotrexate Toxicity

scholarly journals Low-dose Methotrexate Toxicity in the Setting of Vancomycin-induced Acute Kidney Injury

2020 ◽  
Vol 8 (7) ◽  
pp. 206-209
Author(s):  
Lubaina Haider ◽  
Sara Sharif ◽  
Abida Hasan ◽  
Isabel M. McFarlane
Keyword(s):  
Acute Kidney Injury ◽  
Low Dose ◽  
Kidney Injury ◽  
Dose Methotrexate ◽  
Methotrexate Toxicity
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