scholarly journals Low‐Dose Methotrexate and Mucocutaneous Adverse Events: Results of a Systematic Literature Review and Meta‐Analysis of Randomized Controlled Trials

2020 ◽  
Vol 72 (8) ◽  
pp. 1140-1146 ◽  
Author(s):  
Riyana Lalani ◽  
Houchen Lyu ◽  
Kathleen Vanni ◽  
Daniel H. Solomon
Keyword(s):  
Literature Review ◽  
Adverse Events ◽  
Randomized Controlled Trials ◽  
Systematic Literature Review ◽  
Low Dose ◽  
Meta Analysis ◽  
Controlled Trials ◽  
Randomized Controlled ◽  
Dose Methotrexate

scholarly journals Effect of Testosterone Treatment on Cardiovascular Events in Men: Protocol for a Systematic Literature Review and Meta-Analysis (Preprint)

2019 ◽  
Author(s):  
HuiJun Chih ◽  
Christopher M Reid ◽  
Bu B Yeap ◽  
Girish Dwivedi
Keyword(s):  
Literature Review ◽  
Randomized Controlled Trials ◽  
Systematic Literature Review ◽  
Systematic Reviews ◽  
Cardiovascular Events ◽  
Meta Analysis ◽  
Controlled Trials ◽  
Testosterone Treatment ◽  
Coronary Syndrome ◽  
Randomized Controlled

BACKGROUND Testosterone prescriptions have increased dramatically in recent decades, with increasing usage in men. Despite epidemiological associations reported high circulating concentrations of endogenous androgens and low risk of cardiovascular events and mortality, the effects of exogenous androgens in the form of testosterone therapy for maintaining physiological circulating androgen concentrations on the cardiovascular system remain uncertain with no published meta-analysis on this topic. OBJECTIVE The aim of this study was to investigate the effects of prescribed testosterone treatment, in all forms and durations, from well-developed randomized controlled trials, on cardiovascular events in men aged 18 years or older. METHODS Peer-reviewed journal articles published from 1980 to 2019 will be searched from databases (ie CINAHL [Cumulated Index to Nursing and Allied Health Literature], Embase, Medline, Scopus, Cochrane Controlled Register of Trials as well as the Clinical Trial Registry). Randomized controlled trials or cluster randomized controlled trials with at least one intervention arm of testosterone and a control group of usual care or no testosterone treatment will be included in this review and meta-analysis. Studies on men with previous cardiovascular events or cardiac vascularization (coronary bypass surgery or percutaneous coronary intervention) will be excluded. Data related to primary outcomes such as clinical events of any type of stroke or transient ischemic attack, nonfatal myocardial infarction or acute coronary syndrome, emergency coronary artery revascularization, carotid surgery, cardiac mortality, and all-cause mortality will be extracted for analysis. The criteria for PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) will be followed in the evaluation of evidence. RESULTS Search terms have been piloted and finalized. This study will be completed by the end of 2020. CONCLUSIONS This protocol will guide a systematic literature review of the evidence around prescribed testosterone and its effect on cardiovascular events in men aged 18 years or older. The findings will inform clinical management of hypogonadal men. CLINICALTRIAL PROSPERO International Prospective Register of Systematic Reviews CRD42019134278; https://tinyurl.com/y6t7ggge INTERNATIONAL REGISTERED REPORT PRR1-10.2196/15163

scholarly journals The Influence of Different Foods and Food Ingredients on Acute Postprandial Triglyceride Response: A Systematic Literature Review and Meta-Analysis of Randomized Controlled Trials

2020 ◽  
Vol 11 (6) ◽  
pp. 1529-1543
Author(s):  
Delia Pei Shan Lee ◽  
Jasmine Hui Min Low ◽  
Jacklyn Ruilin Chen ◽  
Diane Zimmermann ◽  
Lucas Actis-Goretta ◽  
...  
Keyword(s):  
Literature Review ◽  
Randomized Controlled Trials ◽  
Systematic Literature Review ◽  
Meta Analysis ◽  
Controlled Trials ◽  
Food Groups ◽  
Food Ingredient ◽  
Food Ingredients ◽  
Randomized Controlled ◽  
Postprandial Triglyceride

ABSTRACT The use of postprandial triglyceride (ppTG) as a cardiovascular disease risk indicator has gained recent popularity. However, the influence of different foods or food ingredients on the ppTG response has not been comprehensively characterized. A systematic literature review and meta-analysis was conducted to assess the effects of foods or food ingredients on the ppTG response. PubMed, MEDLINE, Cochrane, and CINAHL databases were searched for relevant acute (<24-h) randomized controlled trials published up to September 2018. Based on our selection criteria, 179 relevant trials (366 comparisons) were identified and systematically compiled into distinct food or food ingredient categories. A ppTG-lowering effect was noted for soluble fiber (Hedges' giAUC = −0.72; 95% CI: −1.33, −0.11), sodium bicarbonate mineral water (Hedges' gAUC = −0.42; 95% CI: −0.79, −0.04), diacylglycerol oil (Hedges' giAUC = −0.38; 95% CI: −0.75, −0.00), and whey protein when it was contrasted with other proteins. The fats group showed significant but opposite effects depending on the outcome measure used (Hedges' giAUC = −0.32; 95% CI: −0.61, −0.03; and Hedges' gAUC = 0.16; 95% CI: 0.06, 0.26). Data for other important food groups (nuts, vegetables, and polyphenols) were also assessed but of limited availability. Assessing for oral fat tolerance test (OFTT) recommendation compliance, most trials were ≥4 h long but lacked a sufficiently high fat challenge. iAUC and AUC were more common measures of ppTG. Overall, our analyses indicate that the effects on ppTG by different food groups are diverse, largely influenced by the type of food or food ingredient within the same group. The type of ppTG measurement can also influence the response.

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