Music in times of Corona - We Shall Overcome

2020 ◽  
Vol 12 (2) ◽  
pp. 71
Author(s):  
Ralph Spintge ◽  
Joanne V. Loewy
Keyword(s):  
Middle Ages ◽  
Social Life ◽  
Travel Speed ◽  
Way Of Life ◽  
Medical Sciences ◽  
Therapeutic Approaches ◽  
Counter Measures ◽  
Fertile Ground ◽  
Life Threatening ◽  
Small Virus

Humankind has faced a myriad of life-threatening challenges in our history, reaching from the so-called Black Death (Yersinia Pestis) killing 40% of Europe´s population during the Middle Ages to Chernobyl and Harrisburg. This time a small virus, a simple chemical particle exploits our global way of life and has served as fertile ground for spreading around the world. Counter measures from medical sciences are rare, and specific drugs or vaccinations at the time of this writing thus far, do not exist. Death tolls are rising, and we are forced to lock down or shut down our social life and stay at home to slow down the travel speed of Corona, thus gaining time to develop therapeutic approaches.

Principles of a Successful Social Life, In The Light of Islamic Teachings

2020 ◽  
Vol 3 (3) ◽  
pp. 37-50
Author(s):  
Muhammad Suleman Nasir
Keyword(s):  
Social Life ◽  
Code Of Conduct ◽  
Well Being ◽  
Human Interaction ◽  
Way Of Life ◽  
The People ◽  
Analytical Research ◽  
Sound Foundation ◽  
Human Intellect ◽  
Islamic Society

Society means a group of people who are living together. People need society from birth to death. Without a collective life, man's deeds, intentions, and habits have no value. Islamic society is the name of a balanced and moderate life in which human intellect, customs, and social etiquette are determined in the light of divine revelation. This system is so comprehensive and all-encompassing that it covers all aspects and activities of life. Islam is a comprehensive, universal, complete code of conduct, and an ideal way of life It not only recognizes the collectiveness of human interaction. Rather, it helps in the development of the community and gives it natural principles that strengthen the community and provides good foundations for it and eliminates the factors that spoil it or make it limited and useless. The Principles of a successful social life in Islamic society seem to reflect the Islamic code of conduct and human nature. Islam is the only religion that advocates goodness and guarantees well-being. Islam gives us self-sacrifice, generosity, trust and honesty, service to the people, justice and fairness, forgiveness and kindness, good society and economy, good deeds, mutual unity, harmony, and brotherhood. Only by practicing the pure thoughts, beliefs, and unparalleled ideas of the religion of Islam, can a person live a prosperous life and he can feel real peace and lasting contentment in the moments of his life. A descriptive and analytical research methodology will be used in this study. It is concluded that for a prosperous social life it is necessary to abide by the injunction of Islamic principles, which provides a sound foundation for a successful social life here in the world and hereafter.

The Influence of Islam on Albanian Culture

2012 ◽  
Vol 8 ◽  
pp. 389-408
Author(s):  
Fatmir Shehu
Keyword(s):  
Cultural Differences ◽  
Social Life ◽  
Historical Background ◽  
Way Of Life ◽  
Islamic Culture ◽  
Cultural System ◽  
The Balkans ◽  
15Th Century ◽  
Of Greece

This paper examines the influence of Islam on Albanian culture. The Islamization process of the Albanian culture was very crucial for the Albanians themselves as it gave them a new identity, which they lacked since their settlement on the Adriatic shores. According to history, Albanians, the biggest Muslim nation dwelling in the Balkans, South-East of Europe, are believed to be the descendents of the ancient Illyrians, who settled in Europe around 2500 years ago. They lived a social life based on tribalism, where every tribe had established its own cultural system and way of life. Thus, their cultural differences disallowed them to unite. Such situation did not change, even when Christianity was introduced to them. Because, Christianity came to Albania through two great dominations: Christian Catholics of Vatican (the Northern part of Albanian) and Christian Orthodox of Greece (the Southern part of Albania). The continuous religious and political suppression faced by the Albanians from their Byzantine and Latin masters enabled them to be the first people of the Balkans, who welcomed openheartedly the Ottoman Muslims and embraced Islam as their new way of life in the 15th century. The study focuses on the following issues: (1) Historical background of Albania and Albanians; (2) The genesis of Albanian culture; and (3) The process of integration between Islamic culture and Albanian culture. This research attempts to provide important findings, which will be very helpful to the Muslims and others.

Alteraciones sistémicas y metabólicas producidas por lesión medular

2019 ◽  
Vol 1 (1) ◽  
pp. 59-75
Author(s):  
Gabriel Guízar Sahagún
Keyword(s):  
Spinal Cord ◽  
Daily Living ◽  
Autonomic Function ◽  
Clinical Presentation ◽  
Scientific Literature ◽  
International Standards ◽  
Therapeutic Approaches ◽  
Cord Injury ◽  
Life Threatening ◽  
The Impact

Besides the well-known loss of motor and sensory capabilities, people with spinal cord injury (SCI) experience a broad range of systemic and metabolic abnormalities including, among others, dysfunction of cardiovascular, respiratory, gastrointestinal, urinary, and endocrine systems. These alterations are a significant challenge for patients with SCI because such disorders severely interfere with their daily living and can be potentially life-threatening. Most of these disorders are associated with impairment of regulation of the autonomic nervous system, arising from disruption of connections between higher brain centers and the spinal cord caudal to the injured zone. Thus, the higher and more complete the lesion, the greater the autonomic dysfunction and the severity of complications.This article summarizes the medical scientific literature on key systemic and metabolic alterations derived of SCI. It provides information primarily focused on the pathophysiology and clinical presentation of these disorders, as well as some guides to prevent and alleviate such complications. Due to the impact of these alterations, this topic must be a priority and diffuse to those involved with the care of people with SCI, including the patient himself/herself. We consider that any collaborative effort should be supported, like the development of international standards, to evaluate autonomic function after SCI, as well as the development of novel therapeutic approaches.

The Epitome of Novel Techniques and Targeting Approaches in Drug Delivery for Treating Lymphatic Filariasis

2020 ◽  
Vol 21 (12) ◽  
pp. 1250-1263
Author(s):  
Saurabh Shrivastava ◽  
Anshita Gupta ◽  
Chanchal Deep Kaur
Keyword(s):  
Lymphatic Filariasis ◽  
Neglected Tropical Diseases ◽  
Therapeutic Interventions ◽  
Tropical Diseases ◽  
Human Beings ◽  
Therapeutic Approaches ◽  
Preventive Chemotherapy ◽  
Bioactive Substances ◽  
Lymphatic Diseases ◽  
Life Threatening

Background: Lymphatic filariasis is a pervasive and life-threatening disease for human beings. Currently, 893 million people in 49 countries worldwide affected by lymphatic filariasis as per WHO statistics. The concealed aspects of lymphatic diseases such as delayed disease detection, inappropriate disease imaging, the geographical outbreak of infection, and lack of preventive chemotherapy have brought this epidemic to the edge of Neglected Tropical Diseases. Many medications and natural bioactive substances have seen to promote filaricidal activity against the target parasitic species. However, the majority of failures have occurred in pharmaceutical and pharmacokinetic issues. Objective: The purpose of the study is to focus on the challenges and therapeutic issues in the treatment of filariasis. The review brings novel techniques and therapeutic approaches for combating lymphatic filariasis. It also offers significant developments and opportunities for such therapeutic interventions. Conclusion: Through this review, an attempt has made to critically evaluate the avenues of innovative pharmaceuticals and molecular targeting approaches to bring an integrated solution to combat lymphatic filariasis.

scholarly journals Similarly Lethal Strains of Extraintestinal Pathogenic Escherichia coli Trigger Markedly Diverse Host Responses in a Zebrafish Model of Sepsis

mSphere ◽  
2016 ◽  
Vol 1 (2) ◽  
Author(s):  
Amelia E. Barber ◽  
Brittany A. Fleming ◽  
Matthew A. Mulvey
Keyword(s):  
The United States ◽  
Host Responses ◽  
Inflammatory Condition ◽  
Therapeutic Approaches ◽  
Zebrafish Model ◽  
Life Threatening ◽  
High Degree ◽  
Care Costs ◽  
Variable Impact ◽  
Degree Of Heterogeneity

ABSTRACT Sepsis is a life-threatening systemic inflammatory condition that is initiated by the presence of microorganisms in the bloodstream. In the United States, sepsis due to ExPEC and other pathogens kills well over a quarter of a million people each year and is associated with tremendous health care costs. A high degree of heterogeneity in the signs and symptomology of sepsis makes this disease notoriously difficult to effectively diagnose and manage. Here, using a zebrafish model of sepsis, we find that similarly lethal but genetically distinct ExPEC isolates can elicit notably disparate host responses. These variances are in part due to differences in the levels and types of flagellin that are expressed by the infecting ExPEC strains. A better understanding of the variable impact that bacterial factors like flagellin have on host responses during sepsis could lead to improved diagnostic and therapeutic approaches to these often deadly infections. In individuals with sepsis, the infecting microbes are commonly viewed as generic inducers of inflammation while the host background is considered the primary variable affecting disease progression and outcome. To study the effects of bacterial strain differences on the maladaptive immune responses that are induced during sepsis, we employed a novel zebrafish embryo infection model using extraintestinal pathogenic Escherichia coli (ExPEC) isolates. These genetically diverse pathogens are a leading cause of sepsis and are becoming increasingly dangerous because of the rise of multidrug-resistant strains. Zebrafish infected with ExPEC isolates exhibit many of the pathophysiological features seen in septic human patients, including dysregulated inflammatory responses (cytokine storms), tachycardia, endothelial leakage, and progressive edema. However, only a limited subset of ExPEC isolates can trigger a sepsis-like state and death of the host when introduced into the bloodstream. Mirroring the situation in human patients, antibiotic therapy reduced ExPEC titers and improved host survival rates but was only effective within limited time frames that varied, depending on the infecting pathogen. Intriguingly, we find that phylogenetically distant but similarly lethal ExPEC isolates can stimulate markedly different host transcriptional responses, including disparate levels of inflammatory mediators. These differences correlate with the amounts of bacterial flagellin expression during infection, as well as differential activation of Toll-like receptor 5 by discrete flagellar serotypes. Altogether, this work establishes zebrafish as a relevant model of key aspects of human sepsis and highlights the ability of genetically distinct ExPEC isolates to induce divergent host responses independently of baseline host attributes. IMPORTANCE Sepsis is a life-threatening systemic inflammatory condition that is initiated by the presence of microorganisms in the bloodstream. In the United States, sepsis due to ExPEC and other pathogens kills well over a quarter of a million people each year and is associated with tremendous health care costs. A high degree of heterogeneity in the signs and symptomology of sepsis makes this disease notoriously difficult to effectively diagnose and manage. Here, using a zebrafish model of sepsis, we find that similarly lethal but genetically distinct ExPEC isolates can elicit notably disparate host responses. These variances are in part due to differences in the levels and types of flagellin that are expressed by the infecting ExPEC strains. A better understanding of the variable impact that bacterial factors like flagellin have on host responses during sepsis could lead to improved diagnostic and therapeutic approaches to these often deadly infections. Podcast: A podcast concerning this article is available.

scholarly journals Efficiency and safety of single dose Magnesium sulphate in eclamptic convulsion

2017 ◽  
Vol 6 (7) ◽  
pp. 3058
Author(s):  
Vinaya Goudar ◽  
Rashmi Naganagoudaru
Keyword(s):  
Single Dose ◽  
Magnesium Sulphate ◽  
Urban Areas ◽  
Low Dose ◽  
Post Partum ◽  
Efficacy And Safety ◽  
Medical Sciences ◽  
Life Threatening ◽  
Clonic Seizures ◽  
Life Threatening Complication

Background: An acute and life-threatening complication of pregnancy is characterized by the appearance of tonic clonic seizures, in a patient with pre-eclampsia. Objective of the study was to study the efficacy and safety of a ‘single dose’ of magnesium sulphate in treatment of eclamptic convulsions.Methods: The present prospective study was undertaken among women aged between 18-35 years outpatient’s Department of gynecology in Karnataka Institute of Medical Sciences (KIMS) Hubli, Karnataka, India. The study was undertaken during December 2009 to November 2010.Results: The incidence of eclampsia in our study was 2.12%. Eclapmsia is more common in patients from rural (89%) as compared to urban areas (11%) in our study. In our study eclampsia is more common in unbooked cases (80%). Majority of patients (72%) in our study group were illiterates. 61%, 28% of patients had antepartum and intrapartum eclampsia respectively in our study. We had only 11 post-partum convulsions Table 2. 80% of patients in our study were more than 28 weeks of gestations. 65% of the patients had <5 episodes of convulsions. The number of convulsions did not affect the recurrence, and 35% had >5 episodes. In present study 5 Patients had Systolic Blood Pressure less than 140 mmHg. Majority (52) had more than 160 mmHg 42 had in between 140 and 160 mmHg. Diastolic arterial pressure was >110 in 81% of cases. The convulsions were controlled in 75% of women. Recurrence of convulsions occurred in 25% of women after receiving the single dose magnesium sulphate regime. In our study 75% of cases, there was no recurrence of convulsions and in 25% of cases, there was recurrence of convulsions, out of which 20 cases received low dose magnesium sulphate regime and the other 5 cases received Phenytoin regime as 2nd line of treatment.Conclusions: Hence the single dose Magnesium sulphate is safe and effective in controlling convulsions.

scholarly journals Vitylo and Cargese

1882 ◽  
Vol 3 ◽  
pp. 354-360
Author(s):  
H. F. Tozer
Keyword(s):  
Middle Ages ◽  
Social Life ◽  
Western Europe ◽  
Ninth Century ◽  
Rocky Shores ◽  
The South ◽  
Western Shore ◽  
The Town ◽  
Modern Form ◽  
Of Greece

The central peninsula of the three that project from the south of the Peloponnese, which since the Middle Ages has been known as the district of Maina, is one of the wildest parts of Greece owing to its rugged mountains and rocky shores, and has always been the abode of independent and intractable races. The emperor Constantine Porphyrogenitus speaks of the Mainotes as having retained their primitive heathenism until the latter half of the ninth century. At the present day they are notorious for their blood-feuds, which are the scourge of the country, and seriously interfere with its social life. On the western shore of this remote district, near a small harbour that runs in from the Messenian gulf, is the town of Vitylo, one of the comparatively few places in the Morea, though these are more numerous on the seaboard than in the interior, which have retained their classical name. It was formerly called and this appellation now appears in the form which accounts for its pronunciation as Vitylo. The modern form of the name is probably the original one, for Ptolemy calls the place Rather more than two centuries ago this town was the scene of a remarkable emigration. At that time the Turks, who had made themselves masters of Crete in 1669, proceeded to attempt the subjugation of Maina. Spon and Wheler, who sailed round cape Matapan on their way to Constantinople in the summer of 1675, were told that the invaders had succeeded in reducing most of the country by means of forts built on the coasts—they seem to have been aided by the treachery of some of the inhabitants—and that part of the population had escaped to Apulia. A few months after these travellers passed by, a number of the inhabitants of Vitylo and its neighbourhood, amounting to about 1000 souls, were persuaded by the Genoese to emigrate under their auspices to Western Europe. They ware led by one of their countrymen, John Stephanopoulos, and were established by their new protectors in Corsica, which was at that time a Genoese possession; and in that island their descendants remain at the present day.

scholarly journals Un paseo por las obras de Lutero = A tour of Luther’s Works

2019 ◽  
Vol 32 ◽  
pp. 107
Author(s):  
Rafael Lazcano
Keyword(s):  
Middle Ages ◽  
Catholic Church ◽  
Human Life ◽  
Protestant Reformation ◽  
Modern World ◽  
Economic Factors ◽  
Word Of God ◽  
Doctrinal Development ◽  
Fertile Ground ◽  
Geographical Expansion

Resumen: La obra de Martín Lutero asienta sus raíces en factores culturales, sociales y económicos, madurados en la Alta Edad Media, y que hicieron fecundo el terreno para la proclamación, expansión geográfica y desarrollo doctrinal de la Reforma protestante. Atrapado por la palabra de Dios, el doctor de Wittenberg, un hombre de fe sencilla y sincera, descubre un nuevo modo de relacionarse con Dios por la «sola fe», la «sola gracia», y la «sola Scriptura», de cara a la justificación/salvación del ser humano. Este singular hallazgo desbanca la doctrina de la iglesia católica medieval, el papa y jerarquías eclesiásticas, indulgencias, reliquias y santos, celibato y vida monástica. Lutero, asimismo, con la fuerza de su palabra abre un horizonte de libertad sobre la vida humana y la sociedad, un nuevo modo de acceder al mundo y a la sociedad, que orientará la trayectoria de la época moderna y del hombre de nuestros días.Palabras clave: Lutero, fe, palabra de Dios, justificación/salvación, Reforma protestante, libertad, mundo moderno.Abstract: Martin Luther’s work was rooted in cultural, social and economic factors, reached maturity in the High Middle Ages, and provided fertile ground for the proclamation, geographical expansion and doctrinal development of the Protestant Reformation. Trapped by the word of God, Luther, a man of simple and sincere faith, discovered a new way of relating to God by sola fide, sola gratia, and sola Scriptura, faced with the justification/salvation of the human being. This unique discovery defeated the doctrine of the medieval Catholic church, the pope and ecclesiastical hierarchies, indulgences, relics and saints, celibacy and monastic life. Like wise, Luther through the strength of his Word opened up a horizon of freedom for human life and society, a new way of accessing the world and society, which would guide the trajectory taken by humans and modernity to this day.Key words: Luther, faith, the word of God, justification/salvation, Protestant Reformation, freedom, modern world.

scholarly journals PIK3CA-Related Overgrowth Spectrum From Diagnosis to Targeted Therapy: A Case of CLOVES Syndrome Treated With Alpelisib

2021 ◽  
Vol 9 ◽  
Author(s):  
Angelica Pagliazzi ◽  
Teresa Oranges ◽  
Giovanna Traficante ◽  
Chiara Trapani ◽  
Flavio Facchini ◽  
...  
Keyword(s):  
Targeted Therapy ◽  
Cellular Proliferation ◽  
Specific Inhibitor ◽  
Molecular Testing ◽  
Sequencing Analysis ◽  
Therapeutic Approaches ◽  
Gain Of Function ◽  
Α Subunit ◽  
Affected Tissue ◽  
Life Threatening

PIK3CA-related overgrowth spectrum (PROS) is an umbrella term referring to various clinical entities, which share the same pathogenetic mechanism. These conditions are caused by somatic gain-of-function mutations in PIK3CA, which encodes the 110-kD catalytic α subunit of PI3K (p110α). These PIK3CA mutations occur as post-zygotic events and lead to a gain of function of PI3K, with consequent constitutional activation of the downstream cascades (e.g., AKT/mTOR pathway), involved in cellular proliferation, survival and growth, as well as in vascular development in the embryonic stage. PIK3CA-related cancers and PROS share almost the same PIK3CA mutational profile, with about 80% of mutations occurring at three hotspots, E542, E545, and H1047. These hotspot mutations show the most potent effect on enzymatic activation of PI3K and consequent downstream biological responses. If present at the germinal level, these gain-of-function mutations would be lethal to the embryo, therefore we only see them in the mosaic state. The common clinical denominator of PROS disorders is that they are sporadic conditions, presenting with congenital or early childhood onset overgrowth with a typical mosaic distribution. However, the severity of PROS is highly variable, ranging from localized and apparently isolate overgrowth to progressive and extensive lipomatous overgrowth associated with life-threatening vascular malformations, as seen in CLOVES syndrome. Traditional therapeutic approaches, such as sclerotherapy and surgical debulking, are often not curative in PROS patients, leading to a recrudescence of the overgrowth in the treated area. Specific attention has been recently paid to molecules that are used and studied in the oncogenic setting and that are targeted on specific alterations of the pathway PI3K/AKT/mTOR. In June 2018, Venot et al. showed the effect of Alpelisib (BYL719), a specific inhibitor for the p110α subunit of PI3K, in patients with PROS disorders who had severe or life-threatening complications and were not sensitive to any other treatment. In these cases, dramatic anatomical and functional improvements occurred in all patients across many types of affected organ. Molecular testing in PROS patients is a crucial step in providing the conclusive diagnosis and then the opportunity for tailored therapy. The somatic nature of this group of diseases makes challenging to reach a molecular diagnosis, requiring deep sequencing methods that have to be performed on DNA extracted from affected tissue. Moreover, even analyzing the DNA extracted from affected tissue there is no guarantee to succeed in detection of the casual somatic mutation, since the affected tissue itself is highly heterogeneous and biopsy approaches can be burdened by incorrect sampling or inadequate tissue sample. We present an 8-year-old girl with CLOVES syndrome, born with a large cystic lymphangioma involving the left hemithorax and flank, multiple lipomas, and hypertrophy of the left foot and leg. She developed severe scoliosis. Many therapeutic approaches have been attempted, including Sildenafil treatment, scleroembolization, laser therapy, and multiple debulking surgeries, but none of these were of benefit to our patient's clinical status. She then started treatment with Rapamycin from May 2019, without significant improvement in both vascular malformation and leg hypertrophy. A high-coverage Whole Exome Sequencing analysis performed on DNA extracted from a skin sample showed a mosaic gain-of-function variant in the PIK3CA gene (p.H1047R, 11% of variant allele frequency). Once molecular confirmation of our clinical suspicion was obtained, after a multidisciplinary evaluation, we decided to discontinue Sirolimus and start targeted therapy with Alpelisib (50 mg/day). We noticed a decrease in fibroadipose overgrowth at the dorsal level, an improvement in in posture and excellent tolerability. The treatment is still ongoing.

scholarly journals The Problem of Individualization in Revealing Humanistic Anthropocentrism of the Renaissance

2020 ◽  
pp. 212-220
Author(s):  
Pavlo PYLYPYSHYN
Keyword(s):  
Human Nature ◽  
Middle Ages ◽  
Interpersonal Relationships ◽  
Social Life ◽  
Free Market ◽  
World Order ◽  
Legal Aspects ◽  
Self Awareness ◽  
Individual Values ◽  
Self Knowledge

It has been proved that after the Middle Ages a new philosophical and legal worldview started to shape, which ensured a significant development of the philosophy of law that enabled emerging individualism. In the philosophy of the Renaissance, the problem of individualism changed its vector from the objective world to all spheres of social life that led to a rise of individual consciousness, causing human’s discovery of itself as a subject of activity. It has been established that the changes also occurred in the type of thinking that moved from collectivist to new thinking focused on defending dignity, the value of an individual, showing interest to interpersonal relationships, respect to individual sense of being, increasing attention to the process of self-knowledge, awareness of individual notion of oneself. It has been proved that the Renaissance relieved a human from external authorities and gave him a space of freedom, in which new notions of human’s place in the world appeared: the role of the state in organizing public life, the importance of social and individual values in taking significant decisions. It has been found out that the reasons that contributed to the emergence of a new individualism in the Renaissance era, in our opinion, include: the replacement of Christian theocentrism with humanistic anthropocentrism; integration of aesthetic and moral ideas taken from the ancient world order; the exit of individual freedom of the subjective «I» from the category of universal, denying the fundamental foundations of the latter; growth of intellectual movement; formation of new economic relations based on the freedom of economic entities; growth of free market economy, raising the prestige of educated people; proclamation of the right to individual initiative, self-awareness; the rise of individual religious consciousness; affirmation of the priority of human nature over the immanent reality; human’s discovery of itself as a subject of activity and law; fast growth of interest to self-knowledge, awareness of individual notion of oneself, transformation of a view of human nature and its relationship with the social and legal aspects of life, significance if internal motifs of individual actions as part of social and legal evaluation of an individual, focusing on humanism. Keywords: individualism, individualization, individuality, personality, individual, Renaissance, freedom.

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