scholarly journals Comparison of eosinophilic cationic protein, adiponectin and leptin levels in patients with allergic rhinitis and local allergic rhinitis

2021 ◽  
Vol 12 (Suppl_4) ◽  
Keyword(s):  
Allergic Rhinitis ◽  
Eosinophilic Cationic Protein ◽  
Cationic Protein ◽  
Local Allergic Rhinitis

scholarly journals Differentiating the endotypes in allergic rhinitis

2021 ◽  
Vol 36 (2) ◽  
pp. 92-97
Author(s):  
A. V. Klimov ◽  
Z. V. Salahutdinova ◽  
N. A. Pronina ◽  
G. A. Kuznetsov
Keyword(s):  
Allergic Rhinitis ◽  
Eosinophil Cationic Protein ◽  
Skin Tests ◽  
Research Trend ◽  
General Group ◽  
Cationic Protein ◽  
Total Ige ◽  
Interleukin 5 ◽  
Local Allergic Rhinitis ◽  
History Of

Aim. The aim of the study was to differentiate the endotypes in allergic rhinitis by key allergy markers in a mixed group of patients.Material and Methods. The study comprised a total of 48 patients, men and women, aged 18-60 years suffering from three endotypes of allergic rhinitis including the classic, local, and dual allergic rhinitis. The standard diagnostics of allergic rhinitis included taking a history of allergies, family history of allergic disease, video rhinoscopy, serum total IgE level assessment, allergy skin tests to house dust mite and pollen allergens, and study of eosinophilic inflammation parameters (eosinophil cationic protein, interleukin-5 (IL5), and eosinophil counts in blood and nasal secretion).Results. Based on total IgE level, the general group of patients was divided to two subgroups: subgroup 1 comprised patients with high IgE level (n = 22); subgroup 2 comprised patients with low IgE level (n = 26). Most of patients in these groups had contradictory results of allergy skin tests i.e. positive allergy skin test results in case of high IgE level (group 1) and vice versa. Cluster analysis-based exminations of general group allowed to categorize three subgroups of patients: patients with classic allergic rhinitis (n = 22), local allergic rhinitis (n = 22), and dual allergic rhinitis (n = 4). Besides, an increased rate of anxiety disorder was found in patients with local allergic rhinitis (p < 0.001).Conclusion. The obtained data showed promise for a new research trend in studying allergic rhinitis endotypes, namely: investigation of neuroimmune relationships in allergic tolerance disruption in the presence of this pathology.

scholarly journals Achievments of control of seasonal allergic rhinitis symptoms: the results of open, randomized comparative study of second generation antihistamines

2017 ◽  
Vol 14 (2) ◽  
pp. 37-46
Author(s):  
O S Bodnya ◽  
N M Nenasheva ◽  
G V Andrenova ◽  
D O Siniavkin ◽  
Y V Bodnya ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Seasonal Allergic Rhinitis ◽  
Second Generation ◽  
Day Treatment ◽  
Allergic Diseases ◽  
Adult Patients ◽  
Eosinophilic Cationic Protein ◽  
Cationic Protein ◽  
First Choice ◽  
Baseline Values

Seasonal allergic rhinitis (SAR) is one of the most common allergic diseases. The first choice for control of SAR symptoms is the second-generation antihistamines (AHP-II). The aim of this study was to evaluate the comparative efficacy of ebastine 20 mg/day, cetirizine 10 mg/day, and loratadine 10 mg/day in adult patients with mild symptoms of SAR due to pollen grass allergy. 30 patients aged 18 to 65 years who received treatment for 14 days took part in the study. The duration of the study for one patient varied from 25 to 28 days. As a result, the efficiency of all three AHP II in the control of mild symptoms of SAR was demonstrated. However, the analysis of the scales (TNSS and TNNSS) after the end of the 14-day treatment period revealed that compared to patients treated with loratadine and cetirizine (TNSS scale (p=0,0303), TNNSS (p=0,0091) the best results were observed in the group of patients taking ebastine. Moreover, patients who received the ebastine experienced a statistically insignificant but steady tendency to decrease the level of eosinophilic cationic protein (ECP) in nasal flushing (-37,9% of the baseline values), in contrast to loratadine and cetirizine. All drugs showed a high safety profile. To conclude, the investigated AHPs -II are effective and safe in control of mild symptoms of SAR in adult patients, though the rate of onset of the effect and its level for nasal and non nasal symptoms was significantly higher in patients receiving ebastine 20 mg compared to cetirizine 10 mg and loratadine 10 mg.

scholarly journals The level of free hemoglobin, eosinophilic cationic protein and eosinophils in nasal secret in patients with allergic and infectious rhinitis

2007 ◽  
Vol 4 (3) ◽  
pp. 20-24
Author(s):  
M A Mokronosova ◽  
Yu I Kochetova ◽  
E V Smol'nikova ◽  
P G Protasov ◽  
M A Mokronosova ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
International Standards ◽  
Diagnostic Efficiency ◽  
Local Inflammation ◽  
Eosinophilic Cationic Protein ◽  
Free Hemoglobin ◽  
Cationic Protein ◽  
Actual Problem ◽  
Severity Of Disease ◽  
Definition Of

Background. Allergic rhinitis manifestates as the local inflammation with minimum pathophysiological disorders. Revealing of local inflammatory markers in nasal secret is actual problem. The aim: to detect the levels of free hemoglobin, eosinophilic cationic protein and eosinophils in nasal secret in patients with allergic rhinitis and infectious rhinitis. Materials and methods. 60 patients with allergic rhinitis and 30 patients with infectious rhinitis were observed. The diagnosis and severity of disease were rated in conformity with international standards. Results. Mean level of free hemoglobin in patients with allergic rhinitis was significantly higher in comparison with the group of infectious rhinitis and had compiled 55,9 mkg/ml and 6,1 mkg/ml. The quantity of eosinophils more than 10% was observed in 43,9% of cases in patients with allergic rhinitis and in 11,1% in patients with infectious rhinitis. Frequency of elevated level of eosinophilic cationic protein in patients with allergic rhinitis has made 87,9%, in comparison with infectious rhinitis where it corresponded to 28%. The highest sensitivity (87,9%) was found in method of definition of eosinophilic cationic protein. Method of free hemoglobin's definition was characterized by high parameter of correct diagnosis's probability - 97,3%. Conclusion. Methods of definition of eosinophilic cationic protein and free hemoglobin in nasal secret had possessed with the highest diagnostic efficiency.

Medical algorithm: Diagnosis and treatment of local allergic rhinitis

Allergy ◽  
2021 ◽  
Author(s):  
Ibon Eguiluz‐Gracia ◽  
Almudena Testera‐Montes ◽  
Carmen Rondon
Keyword(s):  
Allergic Rhinitis ◽  
Diagnosis And Treatment ◽  
Local Allergic Rhinitis

scholarly journals Clinical Phenotype of Local Allergic Rhinitis Driven by Alternaria Alternata Allergen

2021 ◽  
Vol 147 (2) ◽  
pp. AB238
Author(s):  
Almudena Testera-Montes ◽  
Ibon Eguiluz-Gracia ◽  
Adriana Ariza Veguillas ◽  
Maria Salas Cassinello ◽  
Maria Torres ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Alternaria Alternata ◽  
Clinical Phenotype ◽  
Local Allergic Rhinitis

Eosinophilic Cationic Protein in Chronic Eosinophilic Pneumonia and Eosinophilic Granuloma

CHEST Journal ◽  
1994 ◽  
Vol 106 (5) ◽  
pp. 1481-1486 ◽  
Author(s):  
Noriharu Shijubo ◽  
Katsunori Shigehara ◽  
Michio Hirasawa ◽  
Manabu Inuzuka ◽  
Shosaku Abe
Keyword(s):  
Eosinophilic Granuloma ◽  
Eosinophilic Pneumonia ◽  
Eosinophilic Cationic Protein ◽  
Cationic Protein ◽  
Chronic Eosinophilic Pneumonia
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