scholarly journals The level of free hemoglobin, eosinophilic cationic protein and eosinophils in nasal secret in patients with allergic and infectious rhinitis

2007 ◽  
Vol 4 (3) ◽  
pp. 20-24
Author(s):  
M A Mokronosova ◽  
Yu I Kochetova ◽  
E V Smol'nikova ◽  
P G Protasov ◽  
M A Mokronosova ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
International Standards ◽  
Diagnostic Efficiency ◽  
Local Inflammation ◽  
Eosinophilic Cationic Protein ◽  
Free Hemoglobin ◽  
Cationic Protein ◽  
Actual Problem ◽  
Severity Of Disease ◽  
Definition Of

Background. Allergic rhinitis manifestates as the local inflammation with minimum pathophysiological disorders. Revealing of local inflammatory markers in nasal secret is actual problem. The aim: to detect the levels of free hemoglobin, eosinophilic cationic protein and eosinophils in nasal secret in patients with allergic rhinitis and infectious rhinitis. Materials and methods. 60 patients with allergic rhinitis and 30 patients with infectious rhinitis were observed. The diagnosis and severity of disease were rated in conformity with international standards. Results. Mean level of free hemoglobin in patients with allergic rhinitis was significantly higher in comparison with the group of infectious rhinitis and had compiled 55,9 mkg/ml and 6,1 mkg/ml. The quantity of eosinophils more than 10% was observed in 43,9% of cases in patients with allergic rhinitis and in 11,1% in patients with infectious rhinitis. Frequency of elevated level of eosinophilic cationic protein in patients with allergic rhinitis has made 87,9%, in comparison with infectious rhinitis where it corresponded to 28%. The highest sensitivity (87,9%) was found in method of definition of eosinophilic cationic protein. Method of free hemoglobin's definition was characterized by high parameter of correct diagnosis's probability - 97,3%. Conclusion. Methods of definition of eosinophilic cationic protein and free hemoglobin in nasal secret had possessed with the highest diagnostic efficiency.

scholarly journals Achievments of control of seasonal allergic rhinitis symptoms: the results of open, randomized comparative study of second generation antihistamines

2017 ◽  
Vol 14 (2) ◽  
pp. 37-46
Author(s):  
O S Bodnya ◽  
N M Nenasheva ◽  
G V Andrenova ◽  
D O Siniavkin ◽  
Y V Bodnya ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Seasonal Allergic Rhinitis ◽  
Second Generation ◽  
Day Treatment ◽  
Allergic Diseases ◽  
Adult Patients ◽  
Eosinophilic Cationic Protein ◽  
Cationic Protein ◽  
First Choice ◽  
Baseline Values

Seasonal allergic rhinitis (SAR) is one of the most common allergic diseases. The first choice for control of SAR symptoms is the second-generation antihistamines (AHP-II). The aim of this study was to evaluate the comparative efficacy of ebastine 20 mg/day, cetirizine 10 mg/day, and loratadine 10 mg/day in adult patients with mild symptoms of SAR due to pollen grass allergy. 30 patients aged 18 to 65 years who received treatment for 14 days took part in the study. The duration of the study for one patient varied from 25 to 28 days. As a result, the efficiency of all three AHP II in the control of mild symptoms of SAR was demonstrated. However, the analysis of the scales (TNSS and TNNSS) after the end of the 14-day treatment period revealed that compared to patients treated with loratadine and cetirizine (TNSS scale (p=0,0303), TNNSS (p=0,0091) the best results were observed in the group of patients taking ebastine. Moreover, patients who received the ebastine experienced a statistically insignificant but steady tendency to decrease the level of eosinophilic cationic protein (ECP) in nasal flushing (-37,9% of the baseline values), in contrast to loratadine and cetirizine. All drugs showed a high safety profile. To conclude, the investigated AHPs -II are effective and safe in control of mild symptoms of SAR in adult patients, though the rate of onset of the effect and its level for nasal and non nasal symptoms was significantly higher in patients receiving ebastine 20 mg compared to cetirizine 10 mg and loratadine 10 mg.

scholarly journals Rubinstein-Taybi Syndrome: A Model of Epigenetic Disorder

Genes ◽  
2021 ◽  
Vol 12 (7) ◽  
pp. 968
Author(s):  
Julien Van Gils ◽  
Frederique Magdinier ◽  
Patricia Fergelot ◽  
Didier Lacombe
Keyword(s):  
Chromatin Remodeling ◽  
Developmental Disorder ◽  
Facial Dysmorphism ◽  
Diagnostic Efficiency ◽  
Mendelian Disorders ◽  
Pathogenic Variants ◽  
Epigenetic Machinery ◽  
Lysine Acetyltransferase ◽  
Definition Of ◽  
Crebbp Gene

The Rubinstein-Taybi syndrome (RSTS) is a rare congenital developmental disorder characterized by a typical facial dysmorphism, distal limb abnormalities, intellectual disability, and many additional phenotypical features. It occurs at between 1/100,000 and 1/125,000 births. Two genes are currently known to cause RSTS, CREBBP and EP300, mutated in around 55% and 8% of clinically diagnosed cases, respectively. To date, 500 pathogenic variants have been reported for the CREBBP gene and 118 for EP300. These two genes encode paralogs acting as lysine acetyltransferase involved in transcriptional regulation and chromatin remodeling with a key role in neuronal plasticity and cognition. Because of the clinical heterogeneity of this syndrome ranging from the typical clinical diagnosis to features overlapping with other Mendelian disorders of the epigenetic machinery, phenotype/genotype correlations remain difficult to establish. In this context, the deciphering of the patho-physiological process underlying these diseases and the definition of a specific episignature will likely improve the diagnostic efficiency but also open novel therapeutic perspectives. This review summarizes the current clinical and molecular knowledge and highlights the epigenetic regulation of RSTS as a model of chromatinopathy.

scholarly journals Infecting dose and severity of typhoid: analysis of volunteer data and examination of the influence of the definition of illness used

1995 ◽  
Vol 115 (1) ◽  
pp. 23-30 ◽  
Author(s):  
J. R. Glynn ◽  
R. B. Hornick ◽  
M. M. Levine ◽  
D. J. Bradley
Keyword(s):  
Symptom Score ◽  
Salmonella Typhi ◽  
Peak Temperature ◽  
Challenge Dose ◽  
Severity Of Disease ◽  
Definition Of ◽  
The Relationship

SummaryData from volunteers challenged with Salmonella typhi were reanalysed to explore the relationship between challenge dose and severity of disease. Among 120 ill volunteers who received between 105 and 109 organisms, dose was weakly correlated with peak temperature (r = 0·22, 95% CI 0·04–0·39), duration of temperature above 103 °F (39·4 °C: r = 0·13, 95% CI –0·03 to 0·55) and symptom score (r = 0·27, 95% CI 0·09–0·43). The association with symptom score was lost after adjusting for year, and the findings depended on the definition of illness used: with stricter definitions the associations with temperature were also lost. The study shows the need for caution in interpreting the relationship between dose and severity of disease.

Eosinophilic Cationic Protein in Chronic Eosinophilic Pneumonia and Eosinophilic Granuloma

CHEST Journal ◽  
1994 ◽  
Vol 106 (5) ◽  
pp. 1481-1486 ◽  
Author(s):  
Noriharu Shijubo ◽  
Katsunori Shigehara ◽  
Michio Hirasawa ◽  
Manabu Inuzuka ◽  
Shosaku Abe
Keyword(s):  
Eosinophilic Granuloma ◽  
Eosinophilic Pneumonia ◽  
Eosinophilic Cationic Protein ◽  
Cationic Protein ◽  
Chronic Eosinophilic Pneumonia

POTENTIAL OF BANK CURRENCY TRANSACTIONS WITH CRYPTOCURRENCY IN RUSSIA

2021 ◽  
Author(s):  
Юлия Борисовна Арон ◽  
Елена Валерьевна Жегалова
Keyword(s):  
Russian Federation ◽  
Banking System ◽  
Legal Regulation ◽  
Actual Problem ◽  
Digital Currency ◽  
Russian Economy ◽  
The Russian Federation ◽  
Definition Of

В статье рассматривается актуальная проблема интеграции крипто-валюты в банковскую систему РФ. Авторами предлагается определение криптовалюты, обосновывается востребованность использования цифровой валюты в экономике. Рассматривается специфика современного правового регулирования операций с криптовалютой и перспективы его развития в российской экономике. The article deals with the actual problem of integrating cryptocurrency into the banking system of the Russian Federation. The authors propose a definition of cryptocurrency, substantiate the demand for the use of digital currency in the economy. The article considers the specifics of modern legal regulation of cryptocurrency transactions and the prospects for its development in the Russian economy.

EFFECTIVE STEPS ON THE WAY TO MODERNIZATION OF CIVIL SERVICE IN THE SYSTEM OF JUDICIARY BODIES: INTRODUCTION OF ELEMENTS OF GAME THEORY

2018 ◽  
Author(s):  
Olena Hladunova ◽  
Keyword(s):  
Game Theory ◽  
Justice System ◽  
Civil Service ◽  
Civil Servants ◽  
International Standards ◽  
Scientific Article ◽  
Basic Principles ◽  
Conflict Situations ◽  
Definition Of ◽  
The Right

In this scientific article the main elements of game theory are analyzed, the achievements of domestic and foreign scientists devoted to the consideration of such theory are investigated. The expediency of involving in the practical activity of the civil service in the system of judicial authorities effective methods used in the field of business and consisting in the use of game technologies, which have proven their effectiveness in terms of providing quality services. It is focused on the fact that game theory can play a key role in the decision-making process, however, it is important to strictly adhere to the limits of its application. Possible conflict situations in the work of civil servants of the justice system are formulated and it is investigated that in conflict conditions each so-called participant of the game makes his course, i.e. chooses his strategy, as a result of which the relevant conflict situation is outlined and a set of strategies of all players. Some examples of the use of elements of game theory are given and the content of certain types of strategies is revealed. In particular, a strategy is described, which is denoted by the term "screening". Taking into account the definition of ways to modernize the civil service, the need to include in standardized training programs for civil servants of the justice system category "B" training course, which will include the basic principles of game theory for their active use in conflict, skills to compromise in relationships with visitors to the court - recipients of court services, selection of the right strategy, consideration of theoretical and game modeling of personnel management tasks, focusing on the ability to obtain and timely provide the necessary information to create a new civil service in the judiciary that meets international standards.

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