scholarly journals Bio fabrication of gold nanoparticles and their combination with chemotherapy and ultrasound for effective treatment of tumors

2020 ◽  
Vol 20 (2) ◽  
pp. 815-821
Author(s):  
Mingmei Li
Keyword(s):  
Gold Nanoparticles ◽  
Leaf Extract ◽  
New Combination ◽  
Cancer Drug ◽  
Pueraria Lobata ◽  
Au Nps ◽  
Biological Studies ◽  
Anti Cancer ◽  
The Impact ◽  
Anti Tumor Activity

Background and Objective: Chemotherapy is one of the important medical option for the cancer therapy, but still new combination of therapeutic treatment methods are needed to achieve efficient anti tumor activity. In this work, Pueraria lobata leaf extract was utilized as a bio reductant for the fabrication of the Gold nanoparticles (Au-NPs) by an ecological approach without using any harmful chemical. This work also evaluates whether the combined effect of chemotherapy along with Au-NPs and Ultrasound (US) is effective over the tumors or not. Materials and methods: About 10 mL of plant extract was added to 1mM of HAuCl4 solution (20.0 mL) and pH was maintained at 12 and allowed for stirring for half an hour. The change in solution color from yellow to purple signified the Au-NPs formation. Results: XRD results and TEM images confirmed the formation of crystalline Au-NPs with sizes ranging from 23-30 nm. Further, biological studies revealed that the combination of Au-NPs and US along with chemotherapy improved the impact of anti-cancer drug. Conclusion: In conclusion, Pueraria lobata leaf extract mediated synthesis of Au-NPs by an eco-friendly approach was reported in this work. The plant biomolecules of the extract were involved in the reduction and capping of the Au-NPs formed. The major conclusion is that addition of Au-NPs with chemotherapy and ultrasound has shown more effective anti-tumor activity. Keywords: Au-NPs; chemotherapy; ultrasound; plant bio-constituents.

Synthesis of Polynucleotide Modified Gold Nanoparticles as a High Potent Anti-Cancer Drug Carrier

2009 ◽  
Vol 56 (4) ◽  
pp. 703-708 ◽  
Author(s):  
Ching-Ming Wu ◽  
Ping-Ching Wu ◽  
Yun-Han Wang ◽  
Tsung-Ju Li ◽  
Li-Xing Yang ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Drug Carrier ◽  
Cancer Drug ◽  
Anti Cancer

Molecular hydrogen alleviates nephrotoxicity induced by an anti-cancer drug cisplatin without compromising anti-tumor activity in mice

2009 ◽  
Vol 64 (4) ◽  
pp. 753-761 ◽  
Author(s):  
Naomi Nakashima-Kamimura ◽  
Takashi Mori ◽  
Ikuroh Ohsawa ◽  
Sadamitsu Asoh ◽  
Shigeo Ohta
Keyword(s):  
Molecular Hydrogen ◽  
Cancer Drug ◽  
Anti Cancer ◽  
Anti Tumor Activity

Cyclodextrin-covered gold nanoparticles for targeted delivery of an anti-cancer drug

2009 ◽  
Vol 19 (16) ◽  
pp. 2310 ◽  
Author(s):  
Chiyoung Park ◽  
Hyewon Youn ◽  
Hana Kim ◽  
Taiho Noh ◽  
Yeon Hee Kook ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Targeted Delivery ◽  
Cancer Drug ◽  
Anti Cancer

scholarly journals Nuclear targeting of gold nanoparticles

2021 ◽  
Author(s):  
Celina Yang
Keyword(s):  
Cancer Research ◽  
Gold Nanoparticles ◽  
Therapy Response ◽  
Drug Carriers ◽  
Treatment Modalities ◽  
Cancer Drug ◽  
Nuclear Targeting ◽  
The Third ◽  
The Past ◽  
Anti Cancer

Gold nanoparticles (GNPs) have been extensively used in cancer research due to their abilities as anti-cancer drug carriers for chemotherapy and as dose enhancers in radiotherapy. Although most GNP research in the past involved cytoplasm localized GNPs, it is predicted that therapy response can be enhanced if GNPs can be effectively targeted into the nucleus. A strategy for designing a GNP-peptide complex for targeting the nucleus will be presented. Three different sequences of peptides (CKKKKKKGGAGDMFG, CGGRKKRRGRRRAP, CALNN) were conjugated onto GNPs. The first peptide was used to stabilize the complex, the second peptide to enhance uptake into the cell, while the third peptide was used to induce nuclear delivery. With nuclear targeting, more damage can be caused to the DNP of cancer cells upon irradiation. This research will establish a more successful NP-based platform that combines treatment modalities and more effectively approach cancer treatment.

scholarly journals Morinda citrifolia edible leaf extract enhanced immune response against lung cancer

2016 ◽  
Vol 7 (2) ◽  
pp. 741-751 ◽  
Author(s):  
Swee-Ling Lim ◽  
Yong-Meng Goh ◽  
M. Mustapha Noordin ◽  
Heshu S. Rahman ◽  
Hemn H. Othman ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Immune Response ◽  
Leaf Extract ◽  
Complementary Therapies ◽  
Functional Foods ◽  
Morinda Citrifolia ◽  
Cancer Drug ◽  
Anti Cancer

In the search for functional foods as complementary therapies against lung cancer, the immuno-stimulatory properties of the vegetable Morinda citrifolia leaves were investigated and compared with the anti-cancer drug erlotinib.

scholarly journals Acetylenic Synthetic Betulin Derivatives Inhibit Akt and Erk Kinases Activity, Trigger Apoptosis and Suppress Proliferation of Neuroblastoma and Rhabdomyosarcoma Cell Lines

2021 ◽  
Vol 22 (22) ◽  
pp. 12299
Author(s):  
Sylwia K. Król ◽  
Ewa Bębenek ◽  
Magdalena Dmoszyńska-Graniczka ◽  
Adrianna Sławińska-Brych ◽  
Stanisław Boryczka ◽  
...  
Keyword(s):  
Cell Cycle Progression ◽  
Cancer Drug ◽  
Drug Candidate ◽  
Cycle Progression ◽  
Oncological Treatment ◽  
Anti Cancer ◽  
New Compounds ◽  
Anti Tumor Activity ◽  
Reduced Activity

Neuroblastoma (NB) and rhabdomyosarcoma (RMS), the most common pediatric extracranial solid tumors, still represent an important clinical challenge since no effective treatment is available for metastatic and recurrent disease. Hence, there is an urgent need for the development of new chemotherapeutics to improve the outcome of patients. Betulin (Bet), a triterpenoid from the bark of birches, demonstrated interesting anti-cancer potential. The modification of natural phytochemicals with evidenced anti-tumor activity, including Bet, is one of the methods of receiving new compounds for potential implementation in oncological treatment. Here, we showed that two acetylenic synthetic Bet derivatives (ASBDs), EB5 and EB25/1, reduced the viability and proliferation of SK-N-AS and TE671 cells, as measured by MTT and BrdU tests, respectively. Moreover, ASBDs were also more cytotoxic than temozolomide (TMZ) and cisplatin (cis-diaminedichloroplatinum [II], CDDP) in vitro, and the combination of EB5 with CDDP enhanced anti-cancer effects. We also showed the slowdown of cell cycle progression at S/G2 phases mediated by EB5 using FACS flow cytometry. The decreased viability and proliferation of pediatric cancers cells after treatment with ASBDs was linked to the reduced activity of kinases Akt, Erk1/2 and p38 and the induction of apoptosis, as investigated using Western blotting and FACS. In addition, in silico analyses of the ADMET profile found EB5 to be a promising anti-cancer drug candidate that would benefit from further investigation.

scholarly journals Nuclear targeting of gold nanoparticles

2021 ◽  
Author(s):  
Celina Yang
Keyword(s):  
Cancer Research ◽  
Gold Nanoparticles ◽  
Therapy Response ◽  
Drug Carriers ◽  
Treatment Modalities ◽  
Cancer Drug ◽  
Nuclear Targeting ◽  
The Third ◽  
The Past ◽  
Anti Cancer

Gold nanoparticles (GNPs) have been extensively used in cancer research due to their abilities as anti-cancer drug carriers for chemotherapy and as dose enhancers in radiotherapy. Although most GNP research in the past involved cytoplasm localized GNPs, it is predicted that therapy response can be enhanced if GNPs can be effectively targeted into the nucleus. A strategy for designing a GNP-peptide complex for targeting the nucleus will be presented. Three different sequences of peptides (CKKKKKKGGAGDMFG, CGGRKKRRGRRRAP, CALNN) were conjugated onto GNPs. The first peptide was used to stabilize the complex, the second peptide to enhance uptake into the cell, while the third peptide was used to induce nuclear delivery. With nuclear targeting, more damage can be caused to the DNP of cancer cells upon irradiation. This research will establish a more successful NP-based platform that combines treatment modalities and more effectively approach cancer treatment.

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