Cyclodextrin-covered gold nanoparticles for targeted delivery of an anti-cancer drug

2009 ◽  
Vol 19 (16) ◽  
pp. 2310 ◽  
Author(s):  
Chiyoung Park ◽  
Hyewon Youn ◽  
Hana Kim ◽  
Taiho Noh ◽  
Yeon Hee Kook ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Targeted Delivery ◽  
Cancer Drug ◽  
Anti Cancer

Synthesis of Polynucleotide Modified Gold Nanoparticles as a High Potent Anti-Cancer Drug Carrier

2009 ◽  
Vol 56 (4) ◽  
pp. 703-708 ◽  
Author(s):  
Ching-Ming Wu ◽  
Ping-Ching Wu ◽  
Yun-Han Wang ◽  
Tsung-Ju Li ◽  
Li-Xing Yang ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Drug Carrier ◽  
Cancer Drug ◽  
Anti Cancer

scholarly journals Magnetic Alginate / Chitosan Nanoparticles for Targeted Delivery of Curcumin into Human Breast Cancer Cells

2018 ◽  
Author(s):  
Wenxing Song ◽  
Xing Su ◽  
David Gregory ◽  
Wei Li ◽  
Zhiqiang Cai ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Therapy ◽  
Cancer Cells ◽  
Targeted Delivery ◽  
Breast Cancer Cells ◽  
Chitosan Nanoparticles ◽  
Cancer Drug ◽  
Uptake Efficiency ◽  
Anti Cancer ◽  
Hdf Cells

Curcumin is a promising anti-cancer drug but its applications in cancer therapy are limited due to its poor solubility, short half-life and low bioavailability. In this study, curcumin loaded magnetic alginate / chitosan nanoparticles were fabricated to improve the bioavailability, uptake efficiency and cytotoxicity of curcumin to MDA-MB-231 breast cancer cells. Alginate and chitosan were deposited on Fe3O4 magnetic nanoparticles based on their electrostatic properties. The sizes of the nanoparticles (120-200 nm) were within the optimum range for drug delivery. Sustained curcumin release was obtained use the nanoparticles with the ability to control the curcumin release rate by altering the number of chitosan and alginate layers. Confocal fluorescence microscopy results showed that targeted delivery of curcumin with the aid of magnetic field were achieved. The FACS assay indicated that MDA-MB-231 cells treated with curcumin loaded nanoparticles had a 3-6 folds uptake efficiency to those treated with free curcumin. MTT assay indicated that the curcumin loaded nanoparticles exhibited significantly higher cytotoxicity toward MDA-MB-231 cells than toward HDF cells. The sustained release profiles, enhanced uptake efficiency and cytotoxicity to cancer cells as well as the targeting potential make MACPs a promising candidate for cancer therapy.

scholarly journals Nuclear targeting of gold nanoparticles

2021 ◽  
Author(s):  
Celina Yang
Keyword(s):  
Cancer Research ◽  
Gold Nanoparticles ◽  
Therapy Response ◽  
Drug Carriers ◽  
Treatment Modalities ◽  
Cancer Drug ◽  
Nuclear Targeting ◽  
The Third ◽  
The Past ◽  
Anti Cancer

Gold nanoparticles (GNPs) have been extensively used in cancer research due to their abilities as anti-cancer drug carriers for chemotherapy and as dose enhancers in radiotherapy. Although most GNP research in the past involved cytoplasm localized GNPs, it is predicted that therapy response can be enhanced if GNPs can be effectively targeted into the nucleus. A strategy for designing a GNP-peptide complex for targeting the nucleus will be presented. Three different sequences of peptides (CKKKKKKGGAGDMFG, CGGRKKRRGRRRAP, CALNN) were conjugated onto GNPs. The first peptide was used to stabilize the complex, the second peptide to enhance uptake into the cell, while the third peptide was used to induce nuclear delivery. With nuclear targeting, more damage can be caused to the DNP of cancer cells upon irradiation. This research will establish a more successful NP-based platform that combines treatment modalities and more effectively approach cancer treatment.

Harnessing the self-assembly of peptides for the targeted delivery of anti-cancer agents

2020 ◽  
Vol 7 (8) ◽  
pp. 1996-2010 ◽  
Author(s):  
Stephanie J. Franks ◽  
Kate Firipis ◽  
Rita Ferreira ◽  
Katherine M. Hannan ◽  
Richard J. Williams ◽  
...  
Keyword(s):  
Self Assembly ◽  
Targeted Delivery ◽  
Drug Efficacy ◽  
The Self ◽  
Cancer Drug ◽  
Self Assembling ◽  
Anti Cancer ◽  
Therapeutic Molecules ◽  
Peptide Hydrogels

Self-assembling peptide hydrogels can effectively transport, hold and release therapeutic molecules in a spatially and temporally controlled manner and, in doing so, improve anti-cancer drug efficacy while reducing non-specific toxicity.

scholarly journals Nuclear targeting of gold nanoparticles

2021 ◽  
Author(s):  
Celina Yang
Keyword(s):  
Cancer Research ◽  
Gold Nanoparticles ◽  
Therapy Response ◽  
Drug Carriers ◽  
Treatment Modalities ◽  
Cancer Drug ◽  
Nuclear Targeting ◽  
The Third ◽  
The Past ◽  
Anti Cancer

Gold nanoparticles (GNPs) have been extensively used in cancer research due to their abilities as anti-cancer drug carriers for chemotherapy and as dose enhancers in radiotherapy. Although most GNP research in the past involved cytoplasm localized GNPs, it is predicted that therapy response can be enhanced if GNPs can be effectively targeted into the nucleus. A strategy for designing a GNP-peptide complex for targeting the nucleus will be presented. Three different sequences of peptides (CKKKKKKGGAGDMFG, CGGRKKRRGRRRAP, CALNN) were conjugated onto GNPs. The first peptide was used to stabilize the complex, the second peptide to enhance uptake into the cell, while the third peptide was used to induce nuclear delivery. With nuclear targeting, more damage can be caused to the DNP of cancer cells upon irradiation. This research will establish a more successful NP-based platform that combines treatment modalities and more effectively approach cancer treatment.

DNA and aptamer stabilized gold nanoparticles for targeted delivery of anticancer therapeutics

Nanoscale ◽  
2014 ◽  
Vol 6 (13) ◽  
pp. 7436-7442 ◽  
Author(s):  
Alfonso Latorre ◽  
Christian Posch ◽  
Yolanda Garcimartín ◽  
Anna Celli ◽  
Martina Sanlorenzo ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Targeted Delivery ◽  
Cancer Therapeutics ◽  
Malignant Cells ◽  
Anti Cancer ◽  
Anticancer Therapeutics

Aptamer modified gold nanoparticles target malignant cells. Anti-cancer therapeutics are released after cleavage of a self-immolative linker by intracellular triggers.

scholarly journals Bio fabrication of gold nanoparticles and their combination with chemotherapy and ultrasound for effective treatment of tumors

2020 ◽  
Vol 20 (2) ◽  
pp. 815-821
Author(s):  
Mingmei Li
Keyword(s):  
Gold Nanoparticles ◽  
Leaf Extract ◽  
New Combination ◽  
Cancer Drug ◽  
Pueraria Lobata ◽  
Au Nps ◽  
Biological Studies ◽  
Anti Cancer ◽  
The Impact ◽  
Anti Tumor Activity

Background and Objective: Chemotherapy is one of the important medical option for the cancer therapy, but still new combination of therapeutic treatment methods are needed to achieve efficient anti tumor activity. In this work, Pueraria lobata leaf extract was utilized as a bio reductant for the fabrication of the Gold nanoparticles (Au-NPs) by an ecological approach without using any harmful chemical. This work also evaluates whether the combined effect of chemotherapy along with Au-NPs and Ultrasound (US) is effective over the tumors or not. Materials and methods: About 10 mL of plant extract was added to 1mM of HAuCl4 solution (20.0 mL) and pH was maintained at 12 and allowed for stirring for half an hour. The change in solution color from yellow to purple signified the Au-NPs formation. Results: XRD results and TEM images confirmed the formation of crystalline Au-NPs with sizes ranging from 23-30 nm. Further, biological studies revealed that the combination of Au-NPs and US along with chemotherapy improved the impact of anti-cancer drug. Conclusion: In conclusion, Pueraria lobata leaf extract mediated synthesis of Au-NPs by an eco-friendly approach was reported in this work. The plant biomolecules of the extract were involved in the reduction and capping of the Au-NPs formed. The major conclusion is that addition of Au-NPs with chemotherapy and ultrasound has shown more effective anti-tumor activity. Keywords: Au-NPs; chemotherapy; ultrasound; plant bio-constituents.

Sign in / Sign up

Export Citation Format

Share Document