scholarly journals Evaluation of Central Nervous System Acting Effects of Plant-Derived Essential Oils Using Ambulatory Activity in Mice

2013 ◽  
Vol 04 (02) ◽  
pp. 160-170 ◽  
Author(s):  
Toyoshi Umezu
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Essential Oils ◽  
Ambulatory Activity

Sedative Effect of Monoterpene Alcohols in Mice: A Preliminary Screening

2007 ◽  
Vol 62 (7-8) ◽  
pp. 563-566 ◽  
Author(s):  
Damião Pergentino de Sousa ◽  
Ellen Raphael ◽  
Ursula Brocksom ◽  
Timothy John Brocksom
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Essential Oils ◽  
Structural Characteristics ◽  
Sedative Effect ◽  
Depressant Effect ◽  
Preliminary Screening ◽  
The Central Nervous System ◽  
Pharmacological Potential ◽  
Sedative Drugs

Many essential oils and monoterpenes are used therapeutically as relaxing drugs and tranquilizers. In this study, ten structurally related monoterpene alcohols, present in many essential oils, were evaluated in mice to investigate their pharmacological potential in the central nervous system. Isopulegol (1), neoisopulegol (2), (±)-isopinocampheol (3), (-)-myrtenol (4), (-)-cis-myrtanol (5), (+)-p-menth-1-en-9-ol (6) and (±)-neomenthol (8) exhibited a depressant effect in the pentobarbital-induced sleep test, indicating a sedative property. (-)- Menthol (7), (+)-dihydrocarveol (9), and (±)-isoborneol (10) were ineffective in this test. The results show that these psychoactive monoterpenes have the profile of sedative drugs, and this pharmacological effect is influenced by the structural characteristics of the molecules

scholarly journals l-Menthol increases extracellular dopamine and c-Fos-like immunoreactivity in the dorsal striatum, and promotes ambulatory activity in mice

PLoS ONE ◽  
2021 ◽  
Vol 16 (11) ◽  
pp. e0260713
Author(s):  
Toyoshi Umezu ◽  
Tomoharu Sano ◽  
Junko Hayashi
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Motor Activity ◽  
Subcutaneous Administration ◽  
Dorsal Striatum ◽  
Dopamine Level ◽  
Ambulatory Activity ◽  
Extracellular Dopamine ◽  
The Central Nervous System ◽  
Motor Effects

Similar to psychostimulants, the peripheral administration of menthol promotes mouse motor activity, and the neurotransmitter dopamine has been suggested to be involved in this effect. The present study aimed to elucidate the effects of l-menthol on parts of the central nervous system that are involved in motor effects. The subcutaneous administration of l-menthol significantly increased the number of c-Fos-like immunoreactive nuclei in the dorsal striatum of the mice, and motor activity was promoted. It also increased the extracellular dopamine level in the dorsal striatum of the mice. These observations indicated that after subcutaneous administration, l-menthol enhances dopamine-mediated neurotransmission, and activates neuronal activity in the dorsal striatum, thereby promoting motor activity in mice.

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