scholarly journals A Comparative Study on the Efficacy of Some Artemisinin Combination Therapies on <i>Plasmodium berghei</i> in Swiss Albino Mice

2012 ◽  
Vol 03 (01) ◽  
pp. 109-112 ◽  
Author(s):  
U. O. Georgewill ◽  
O. O. Ebong
Keyword(s):  
Comparative Study ◽  
Plasmodium Berghei ◽  
Combination Therapies ◽  
Swiss Albino Mice ◽  
Albino Mice ◽  
Artemisinin Combination Therapies

scholarly journals Evaluation of Antiplasmodial Activity of Hydroalcoholic Crude Extract and Solvent Fractions of Zehneria scabra Roots Against Plasmodium berghei in Swiss Albino Mice

2021 ◽  
Vol Volume 14 ◽  
pp. 2583-2596
Author(s):  
Dejen Nureye ◽  
Eyob Tekalign ◽  
Nebeyi Fisseha ◽  
Tarekegn Tesfaye ◽  
Workineh Woldeselassie Hammeso
Keyword(s):  
Crude Extract ◽  
Plasmodium Berghei ◽  
Antiplasmodial Activity ◽  
Swiss Albino Mice ◽  
Albino Mice

scholarly journals Comparative study of subchronic toxicities of mosquito repellents (coils, mats and liquids) on vital organs in Swiss albino mice

2019 ◽  
Vol 27 (3) ◽  
pp. 348-353 ◽  
Author(s):  
Mamuna Naz ◽  
Najeeb Rehman ◽  
Mohd Nazam Ansari ◽  
Mehnaz Kamal ◽  
Majid A. Ganaie ◽  
...  
Keyword(s):  
Comparative Study ◽  
Swiss Albino Mice ◽  
Mosquito Repellents ◽  
Albino Mice

scholarly journals Hematological and Histopathological Profiles of Swiss Albino Mice Infected with Plasmodium berghei upon Treatment with Cooked Tetracarpidium conophorum Seed Ethanol Extract

2021 ◽  
pp. 22-37
Author(s):  
Dada Ebenezer ◽  
Oladipo Faith Temiloluwa
Keyword(s):  
Body Weight ◽  
Plasmodium Berghei ◽  
Hematological Parameters ◽  
Haemoglobin Concentration ◽  
Ethanol Extract ◽  
Seed Extract ◽  
Mean Corpuscular Hemoglobin ◽  
Swiss Albino Mice ◽  
Albino Mice ◽  
Group 5

Aim: This study was conducted to verify the hematological and histopathological outcome of cooked ethanol seed extract of Tetracarpidium conophorum in swiss albino mice infected with Plasmodium berghei (NK65). Study Design: Descriptive study. Methodology: Standard methods were conducted to determine the phyto-chemical profile of cooked T. conophorum seed ethanol extract, hematological, histopathological indices and biochemical assay. Mice were assembled into five groups (1, 2, 3, 4 and 5) of seven each. The mice in group 4 were treated with a customary antimalarial drug (chloroquine as positive control) at a dose of 5 mg/kg body weight, while mice in groups 3, 2 and 1 was administered with increasing dosages (200, 400, 800 mg/kg body weight) of seed extracts for four consecutive days respectively. Results: The qualitative phytochemical screening of T. conophorum seed extract revealed the presence of bioactive components such as saponin, tannins, flavonoid, terpenoid. Saponin (16.82 mg/100 g) was the highest occurring phytochemical followed by terpenoid (10.39 mg/100 g), glycoside (5.9 mg/100 g), tannin (2.8 mg/100 g) and flavonoid (1.17 mg/100 g), while steroid only had a trace presence. Hematological parameters revealed mice in all groups do not possess significantly different mean corpuscular haemoglobin concentration (MCHC), mean corpuscular hemoglobin (MCH) and mean corpuscular volume (MCV). Mice in group 5 (infected and not treated) demonstrated lowest values of hemoglobin, platelet, and packed cell volume with a significantly lower % eosin. There was considerable decrease in the levels of alanine transaminase and aspartate transaminase in group 5 compared to mice in groups 1, 2, and 3. Conclusion: Ameliorative effects of seed extract were observed on the liver and kidney of mice at dose levels (200 mg/kg) used, but the 400 mg/kg restored the kidney but had adverse effect on the liver. This study therefore shows that cooked T. conophorum is generally less effective and could not be employed for treatment of malaria.

scholarly journals Antiplasmodial and haematological effects of Senna occidentalis leaf ethanolic extracts on Swiss albino mice infected with Plasmodium berghei

2021 ◽  
Vol 12 (2) ◽  
pp. 122-128
Author(s):  
S.M. Babangida ◽  
G.J. Sow ◽  
D.M. Shehu
Keyword(s):  
Plasmodium Berghei ◽  
Blood Cells ◽  
Leaf Extract ◽  
White Blood Cells ◽  
Control Group ◽  
Phytochemical Analysis ◽  
Leaf Extracts ◽  
Swiss Albino Mice ◽  
Ethanolic Extracts ◽  
Albino Mice

A research was conducted to investigate the haematological effects of ethanolic leaf extracts of Senna occidentalis on Swiss albino mice infected with 0.2 ml of Plasmodium berghei infected blood. Fifteen (15) mice weighing between 140-260g were assigned into five study groups of three mice each. The first group is treated with 0.2 mL of normal saline (drug free control). Group 2, 3, 4 were treated with 100, 200, and 400mg/kg of theethanolic leaf extract respectively while group 5 received 10mg/kg of chloroquine phosphate. All doses were administered orally. The results obtained were analyzed using Analysis of Variance with Duncan’s Multiple Range Test to separate the means. The result of the preliminary phytochemical analysis revealed the presence of alkaloids, saponins, cardiac glycosides, diterpenoids, flavonoids, steroids, tannins, Triterpenoids, carbohydrates and proteins. The level of parasite suppression ranges from 35% to 75% and the activity increased with increase in concentration of the extracts (dose dependent). The extracts were found to increase the level of some haematological parameters such as Red Blood Cells, White Blood Cells and Haemoglobin. The effect is concentration dependent, increases with increase in concentration. Thus, the anti plasmodial efficacy of the leaf extract of S. occidentalis on P. berghei is confirmed. It is recommended that , 400 mg/kg leaf ethanolic extracts of S. occidentalis couldbe use in the treatment of malarial fever.

A comparative study of spermiogenesis in wild-type and T:t-bearing mice

Development ◽  
1978 ◽  
Vol 44 (1) ◽  
pp. 243-261
Author(s):  
Nina Hillman ◽  
Mary Nadijcka
Keyword(s):  
Comparative Study ◽  
Ultrastructural Study ◽  
Wild Type ◽  
Transmission Frequency ◽  
Swiss Albino Mice ◽  
Albino Mice

The results of a comparative ultrastructural study of spermiogenesis in T/tx, +/tx, +/T, C57BL/6J, BALB/c and randomly breeding Swiss Albino mice are reported. The observations show that aberrant spermiogenesis occurs in males of all strains and genotypes and that the same specific types of abnormal spermatids are found in all of the males examined. No unique morphological defect which could be correlated with the increased transmission frequency of tx-bearing gametes can be found in males heterozygous for the tx allele.

Sign in / Sign up

Export Citation Format

Share Document