scholarly journals Primary sinonasal malignant melanoma: a nationwide study of the Swedish population, 1960–2000

2013 ◽  
Vol 51 (1) ◽  
pp. 22-30 ◽  
Author(s):  
M. Jangard ◽  
J. Hansson ◽  
B. Ragnarsson-Olding
Keyword(s):  
Malignant Melanoma ◽  
Swedish Population ◽  
Nationwide Study ◽  
Sinonasal Malignant Melanoma

scholarly journals Primary sinonasal malignant melanoma: a nationwide study of the Swedish population, 1960-2000

2013 ◽  
Vol 51 (1) ◽  
pp. 22-30
Author(s):  
M. Jangard ◽  
J. Hansson ◽  
B. Ragnarsson-Olding
Keyword(s):  
Malignant Melanoma ◽  
Therapeutic Strategy ◽  
Survival Rates ◽  
Primary Treatment ◽  
Population Based ◽  
Cutaneous Malignant Melanoma ◽  
Mucosal Melanoma ◽  
Swedish Population ◽  
Gender And Age ◽  
Sinonasal Malignant Melanoma

Objective: To establish population-based trends for sinonasal mucosal melanoma (SNMM) in Sweden. Methods: We identified 186 patients from the Swedish National Cancer Registry diagnosed with primary melanomas arising from the nasal cavity, paranasal sinuses, or both, during the period 1960 through 2000. Incidence, gender and age, primary anatomical sites, geographic distribution, treatment and survival were investigated. Results: The age-standardized incidence of SNMM increased significantly during the 41-year-period, with a higher overall incidence for females than males, but with a more rapid increase for males than for females. The incidence increased with age, peaking after the eightieth year in both genders. About 70 % of the cases were clinically amelanotic. The most common primary treatment was surgery. Five-year, disease-specific survival rates were poor for all these patients, but women had a significantly better survival time than men. For both genders the survival rate lengthened during the study period, irrespective of therapeutic strategy. Conclusion: SNMM is a rare disease, but the incidence in Sweden has increased significantly from 1960 through 2000, although not at the same pace as that of cutaneous malignant melanoma. Both the incidence and the survival were significantly higher in females than in males, but the reason for these gender differences is unknown.

scholarly journals Sinonasal malignancies in Sweden 1960-2010; a nationwide study of the Swedish population

2015 ◽  
Vol 53 (1) ◽  
pp. 75-80
Author(s):  
A. Elliot ◽  
M. Jangard ◽  
L. Marklund ◽  
N. Hakansson ◽  
P. Dickman ◽  
...  
Keyword(s):  
Nasal Cavity ◽  
Relative Survival ◽  
Population Based ◽  
Undifferentiated Carcinoma ◽  
Swedish Population ◽  
Nationwide Study ◽  
Adenoid Cystic ◽  
Sinonasal Malignancies ◽  
Gender And Age ◽  
Sinonasal Malignant Melanoma

Introduction: Sinonasal malignancies (SNM) are rare and the prognosis is generally poor. Recently, a change in incidence for SNM has been reported. In this study, we investigated population-based trends for SNM in Sweden. Methods: We identified 3,221 patients from the Swedish National Cancer Registry diagnosed with primary malignancies arising from the nasal cavity, paranasal sinuses, or both, during the period 1960 through 2010. Incidence, gender and age, anatomical sites and relative survival were investigated. Results: The incidence for SNM decreased except for sinonasal malignant melanoma (SNMM) and adenoid cystic cancer (even though a very small group) during the study period. More than 50 % of the malignancies involved the nasal cavity. The five-year relative survival was highest for adenoid cystic cancer followed by adenocarcinoma. SNMM and undifferentiated carcinoma had the poorest prognosis. Conclusion: We found that the incidence for SNM has decreased during the study period 1960 through 2010, except for SNMM that has increased.

Local control in sinonasal malignant melanoma: Comparing conventional to hypofractionated radiotherapy

Head & Neck ◽  
2017 ◽  
Vol 40 (1) ◽  
pp. 86-93 ◽  
Author(s):  
Jules Lansu ◽  
Willem Martin Klop ◽  
Wilma Heemsbergen ◽  
Arash Navran ◽  
Abrahim Al-Mamgani ◽  
...  
Keyword(s):  
Malignant Melanoma ◽  
Local Control ◽  
Hypofractionated Radiotherapy ◽  
Sinonasal Malignant Melanoma

Malignant melanoma arising in the frontal sinuses

1997 ◽  
Vol 111 (4) ◽  
pp. 376-378 ◽  
Author(s):  
Samuel M. Jayaraj ◽  
Jonathan D. Hern ◽  
George Mochloulis ◽  
Graham C. Porter
Keyword(s):  
Malignant Melanoma ◽  
Natural History ◽  
Nasal Cavity ◽  
Paranasal Sinuses ◽  
Frontal Sinus ◽  
Poor Prognosis ◽  
Review Of The Literature ◽  
History Of ◽  
Frontal Sinuses ◽  
Sinonasal Malignant Melanoma

AbstractSinonasal malignant melanoma is rare and usually occurs in the nasal cavity. Presentation is often varied and occurs late in the natural history of the disease, resulting in a poor prognosis. A case is reported of a patient with malignant melanoma arising from the frontal sinus who presented with a forehead swelling and progressive confusion. A review of the literature on malignant melanoma in the nasal cavity and paranasal sinuses regarding its presentation, site of origin and principles of management is discussed.

scholarly journals Risk of Stroke in Patients With Atrial Fibrillation Is Associated With Stroke in Siblings: A Nationwide Study

2020 ◽  
Vol 9 (3) ◽  
Author(s):  
John Berntsson ◽  
Xinjun Li ◽  
Bengt Zöller ◽  
Andreas Martinsson ◽  
Pontus Andell ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Ischemic Stroke ◽  
Hazard Ratio ◽  
Swedish Population ◽  
Total Study Population ◽  
Nationwide Study ◽  
Increased Risk ◽  
Study Population ◽  
Traditional Risk Factors ◽  
Swedish Patient

Background It remains unclear whether heritable factors can contribute to risk stratification for ischemic stroke in patients with atrial fibrillation (AF). We examined whether having a sibling with ischemic stroke was associated with increased risk of ischemic stroke and mortality in patients with AF . Methods and Results In this nationwide study of the Swedish population, patients with AF and their siblings were identified from the Swedish patient registers and the Swedish MGR (Multi‐Generation Register). Ischemic stroke events were retrieved from the Swedish patient registers and CDR (Cause of Death Register). Risk of ischemic stroke was compared between patients with AF with and without a sibling affected by ischemic stroke, AF , or both ischemic stroke and AF . The total study population comprised 113 988 subjects (mean age, 60±12 years) diagnosed with AF between 1989 and 2012. In total, 11 709 of them were diagnosed with a first ischemic stroke and 20 097 died during a mean follow‐up time of 5.5 years for ischemic stroke and 5.9 years for mortality. After adjustment for covariates having a sibling with ischemic stroke, or both ischemic stroke and AF , was associated with increased risk of ischemic stroke (hazard ratio, 1.31; 95% CI, 1.23–1.40 or hazard ratio, 1.36; 95% CI , 1.24–1.49, respectively). Furthermore, ischemic stroke in a sibling was associated with all‐cause mortality (hazard ratio, 1.09; 95% CI , 1.05–1.14). In contrast, the risk of stroke was only marginally increased for patients with AF with a spouse affected by ischemic stroke. Conclusions Having a sibling affected by ischemic stroke confers an increased risk of ischemic stroke and death independently of traditional risk factors in patients with AF.

scholarly journals Primary Sinonasal Malignant Melanoma: Effect of Clinical and Histopathologic Prognostic Factors on Survival

2017 ◽  
Vol 34 (3) ◽  
pp. 255-262 ◽  
Author(s):  
Sercan Göde ◽  
Göksel Turhal ◽  
Ceyda Tarhan ◽  
Banu Yaman ◽  
Gülşen Kandiloğlu ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Malignant Melanoma ◽  
Sinonasal Malignant Melanoma
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