scholarly journals Post-Breast Cancer Radiotherapy Bronchiolitis Obliterans Organizing Pneumonia

2019 ◽  
Vol 65 (5) ◽  
pp. 686-692
Author(s):  
Gary R Epler ◽  
Eileen M Kelly
Keyword(s):  
Breast Cancer ◽  
Bronchiolitis Obliterans ◽  
Organizing Pneumonia ◽  
Cancer Radiotherapy ◽  
Bronchiolitis Obliterans Organizing Pneumonia ◽  
Breast Cancer Radiotherapy

scholarly journals Bronchiolitis Obliterans Organizing Pneumonia after Breast Cancer Radiotherapy and letrozole: A Case Report and Literature Review

2021 ◽  
Vol 4 (3) ◽  
pp. 01-05
Author(s):  
Alati Aurélia ◽  
Clavère Pierre ◽  
Leobon Sophie
Keyword(s):  
Conservative Treatment ◽  
Bronchiolitis Obliterans ◽  
Radiation Treatment ◽  
Ductal Carcinoma ◽  
New Drugs ◽  
Imaging Features ◽  
Organizing Pneumonia ◽  
Bronchiolitis Obliterans Organizing Pneumonia ◽  
Breast Cancer Radiotherapy ◽  
Imaging Results

Objectives: Bronchiolitis obliterans organizing pneumonia occurs with prevalence rate 1–3% after breast conservative treatment in series. In response to radiation of a lung or surrounding tissues, an inflammatory reaction can affect both lungs and is located within the radiation field. Characteristic imaging features include multiple alveolar opacities and diffuse ground-glass shadows. Letrozole may induce iatrogenic organizing pneumonia. Materials and methods: we report the case of a 76-year-old female who underwent conservative treatment for an invasive ductal carcinoma of the left breast. Hypofractionated radiotherapy was delivered with a total dose of 42.5 Gy in 16 sessions of 2.65 Gy using a three-dimensional technique. After the radiotherapy ended letrozole was indicated. Results: Several weeks after the radiotherapy ended and letrozole was introduced, she described a flu-like syndrome. Samples were negative, and there was no improvement after four courses of antibiotics. Imaging suggested bronchiolitis obliterans organizing pneumonia. Her symptomatology lessened after the letrozole was discontinued, and 11 months after radiotherapy finished, her imaging results were clear. Conclusion: Physicians must consider bronchiolitis obliterans organizing pneumonia. Cases may increase with hypofractionated radiation treatment and new drugs. Letrozole may potentiate the risk. Dosimetry may be adapted to the lung and subpleural areas for patients with risk factors and taking adjuvant or concurrent drugs with potential pneumotoxicity.

scholarly journals Bronchiolitis Obliterans Organizing Pneumonia after Breast Cancer Radiotherapy and letrozole: A Case Report and Literature Review

2021 ◽  
Vol 4 (3) ◽  
pp. 01-05
Author(s):  
Alati Aurélia ◽  
Clavère Pierre ◽  
Leobon Sophie
Keyword(s):  
Conservative Treatment ◽  
Bronchiolitis Obliterans ◽  
Radiation Treatment ◽  
Ductal Carcinoma ◽  
New Drugs ◽  
Imaging Features ◽  
Organizing Pneumonia ◽  
Bronchiolitis Obliterans Organizing Pneumonia ◽  
Breast Cancer Radiotherapy ◽  
Imaging Results

Objectives: Bronchiolitis obliterans organizing pneumonia occurs with prevalence rate 1–3% after breast conservative treatment in series. In response to radiation of a lung or surrounding tissues, an inflammatory reaction can affect both lungs and is located within the radiation field. Characteristic imaging features include multiple alveolar opacities and diffuse ground-glass shadows. Letrozole may induce iatrogenic organizing pneumonia. Materials and methods: we report the case of a 76-year-old female who underwent conservative treatment for an invasive ductal carcinoma of the left breast. Hypofractionated radiotherapy was delivered with a total dose of 42.5 Gy in 16 sessions of 2.65 Gy using a three-dimensional technique. After the radiotherapy ended letrozole was indicated. Results: Several weeks after the radiotherapy ended and letrozole was introduced, she described a flu-like syndrome. Samples were negative, and there was no improvement after four courses of antibiotics. Imaging suggested bronchiolitis obliterans organizing pneumonia. Her symptomatology lessened after the letrozole was discontinued, and 11 months after radiotherapy finished, her imaging results were clear. Conclusion: Physicians must consider bronchiolitis obliterans organizing pneumonia. Cases may increase with hypofractionated radiation treatment and new drugs. Letrozole may potentiate the risk. Dosimetry may be adapted to the lung and subpleural areas for patients with risk factors and taking adjuvant or concurrent drugs with potential pneumotoxicity.

scholarly journals Cryptogenic organizing pneumonia after radiotherapy for breast cancer

2010 ◽  
Vol 5 ◽  
Author(s):  
Giorgio Fumagalli ◽  
Claudio M. Sanguinetti
Keyword(s):  
Breast Cancer ◽  
Bronchiolitis Obliterans ◽  
Hormone Treatment ◽  
Organizing Pneumonia ◽  
Disease Relapse ◽  
Cryptogenic Organizing Pneumonia ◽  
Bronchiolitis Obliterans Organizing Pneumonia ◽  
Radiation Fields ◽  
Bilateral Lung ◽  
Withdrawal Of Therapy

We report a case of fever, dyspnea, respiratory failure and migratory, recurrent and bilateral lung opacities 4 months after radiotherapy and hormone therapy following surgery for breast cancer. Computerized tomography (CT) scans showed infiltrates outside the radiation fields. Bronchoalveolar lavage revealed lymphocytic alveolitis, whereas laboratory analysis demonstrated a mild systemic inflammation. Systemic steroids resulted in clinical and radiological improvement, but a disease relapse was evident at withdrawal of therapy, with definitive clinical and radiological normalization after a second cycle of therapy. This is a case of cryptogenic organizing pneumonia (COP) (previously known as bronchiolitis obliterans organizing pneumonia) primed by radiotherapy, as in previously reported cases. It is extremely important to be aware of the possibility of this complication, in order to optimize radiation and hormone treatment of breast cancer.

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