scholarly journals Cryptogenic organizing pneumonia after radiotherapy for breast cancer

2010 ◽  
Vol 5 ◽  
Author(s):  
Giorgio Fumagalli ◽  
Claudio M. Sanguinetti
Keyword(s):  
Breast Cancer ◽  
Bronchiolitis Obliterans ◽  
Hormone Treatment ◽  
Organizing Pneumonia ◽  
Disease Relapse ◽  
Cryptogenic Organizing Pneumonia ◽  
Bronchiolitis Obliterans Organizing Pneumonia ◽  
Radiation Fields ◽  
Bilateral Lung ◽  
Withdrawal Of Therapy

We report a case of fever, dyspnea, respiratory failure and migratory, recurrent and bilateral lung opacities 4 months after radiotherapy and hormone therapy following surgery for breast cancer. Computerized tomography (CT) scans showed infiltrates outside the radiation fields. Bronchoalveolar lavage revealed lymphocytic alveolitis, whereas laboratory analysis demonstrated a mild systemic inflammation. Systemic steroids resulted in clinical and radiological improvement, but a disease relapse was evident at withdrawal of therapy, with definitive clinical and radiological normalization after a second cycle of therapy. This is a case of cryptogenic organizing pneumonia (COP) (previously known as bronchiolitis obliterans organizing pneumonia) primed by radiotherapy, as in previously reported cases. It is extremely important to be aware of the possibility of this complication, in order to optimize radiation and hormone treatment of breast cancer.

scholarly journals A Case of Cryptogenic Organizing Pneumonia Occurring in Crohn’s Disease

2005 ◽  
Vol 12 (8) ◽  
pp. 437-439 ◽  
Author(s):  
Pierluigi Carratù ◽  
Silvano Dragonieri ◽  
Maria Cristina Nocerino ◽  
Senia Maria Rosaria Trabucco ◽  
Donato Lacedonia ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Bronchiolitis Obliterans ◽  
Clinical Findings ◽  
Organizing Pneumonia ◽  
Extraintestinal Manifestation ◽  
Cryptogenic Organizing Pneumonia ◽  
Bronchiolitis Obliterans Organizing Pneumonia ◽  
Lung Histology

A 29 year-old-man with Crohn's disease, who developed diffuse pulmonary infiltrates and hypoxemia two months following oral administration of mesalazine, was examined. Clinical findings and computed tomography were suggestive of, and lung histology was diagnostic of, bronchiolitis obliterans organizing pneumonia, also known as cryptogenic organizing pneumonia. Although the data did not allow for definitive conclusions, they did suggest that the pulmonary disease was an extraintestinal manifestation of Crohn's disease, rather than an adverse reaction to mesalazine. In fact, the patient showed clinical, radiological and functional improvements, despite the treatment with mesalazine and the withdrawal of steroid therapy.

Sign in / Sign up

Export Citation Format

Share Document