scholarly journals Are extracellular matrix surface network components involved in signalling and protective function?

2008 ◽  
Vol 3 (9) ◽  
pp. 707-709 ◽  
Author(s):  
Marzena Popielarska-Konieczna ◽  
Małgorzata Kozieradzka-Kiszkurno ◽  
Joanna Świerczyńska ◽  
Grzegorz Góralski ◽  
Halina Ślesak ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Protective Function ◽  
Matrix Surface ◽  
Surface Network

scholarly journals Extracellular matrix surface network is associated with non-morphogenic calli of Helianthus tuberosus cv. Albik produced from various explants

2014 ◽  
Vol 83 (1) ◽  
pp. 67-73 ◽  
Author(s):  
Maria Pilarska ◽  
Marzena Popielarska-Konieczna ◽  
Halina Ślesak ◽  
Małgorzata Kozieradzka-Kiszkurno ◽  
Grzegorz Góralski ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
In Vitro Regeneration ◽  
Vascular Bundles ◽  
Helianthus Tuberosus ◽  
Important Species ◽  
Electron Microscopies ◽  
Transmission Electron ◽  
Matrix Surface ◽  
Surface Network

<em>Helianthus tuberosus</em> is economically important species. To improve characters of this energetic plant via genetic modification, production of callus tissue and plant regeneration are the first steps. A new, potentially energetic cultivar Albik was used in this study to test callus induction and regeneration. Callus was produced on leaves, petioles, apical meristems and stems from field-harvested plants but was totally non-morphogenic. Its induction started in the cortex and vascular bundles as confirmed by histological analysis. The surface of heterogeneous callus was partially covered with a membranous extracellular matrix surface network visible in scanning and transmission electron microscopies. The results clearly indicate that: (<strong><em>i</em></strong>) the morphogenic capacity of callus in topinambur is genotype dependent, (<strong><em>ii</em></strong>) cv. Albik of <em>H. tuberosus</em> proved recalcitrant in in vitro regeneration, and (<strong><em>iii</em></strong>) extracellular matrix surface network is not a morphogenic marker in this cultivar.

Ultrastructure and histochemical analysis of extracellular matrix surface network in kiwifruit endosperm-derived callus culture

2008 ◽  
Vol 27 (7) ◽  
pp. 1137-1145 ◽  
Author(s):  
M. Popielarska-Konieczna ◽  
M. Kozieradzka-Kiszkurno ◽  
J. Świerczyńska ◽  
G. Góralski ◽  
H. Ślesak ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Callus Culture ◽  
Histochemical Analysis ◽  
Matrix Surface ◽  
Surface Network

Extracellular Matrix Surface Network During Plant Regeneration in Wheat Anther Culture

2005 ◽  
Vol 83 (2) ◽  
pp. 201-208 ◽  
Author(s):  
R. Konieczny ◽  
J. Bohdanowicz ◽  
A.Z. Czaplicki ◽  
L. Przywara
Keyword(s):  
Extracellular Matrix ◽  
Plant Regeneration ◽  
Anther Culture ◽  
Matrix Surface ◽  
Surface Network

A fusion protein N-cadherin-Fc as an artificial extracellular matrix surface for maintenance of stem cell features

Biomaterials ◽  
2010 ◽  
Vol 31 (20) ◽  
pp. 5287-5296 ◽  
Author(s):  
Xiao-Shan Yue ◽  
Yuta Murakami ◽  
Toshiyuki Tamai ◽  
Masato Nagaoka ◽  
Chong-Su Cho ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Stem Cell ◽  
Fusion Protein ◽  
Matrix Surface ◽  
Artificial Extracellular Matrix

scholarly journals Cysteine Peptidases of Mammals: Their Biological Roles and Potential Effects in the Oral Cavity and Other Tissues in Health and Disease

2002 ◽  
Vol 13 (3) ◽  
pp. 238-275 ◽  
Author(s):  
D.P. Dickinson
Keyword(s):  
Extracellular Matrix ◽  
Oral Cavity ◽  
Cell Function ◽  
Human Saliva ◽  
Protective Function ◽  
Cysteine Peptidases ◽  
Genes Encoding ◽  
Foreign Proteins ◽  
Health And Disease

Cysteine peptidases (CPs) are phylogenetically ubiquitous enzymes that can be classified into clans of evolutionarily independent proteins based on the structural organization of the active site. In mammals, two of the major clans represented in the genome are: the CA clan, whose members share a structure and evolutionary history with papain; and the CD clan, which includes the legumains and caspases. This review focuses on the properties of these enzymes, with an emphasis on their potential roles in the oral cavity. The human genome encodes at least (but possibly no more than) 11 distinct enzymes, called cathepsins, that are members of the papain family C1A. Ten of these are present in rodents, which also carry additional genes encoding other cathepsins and cathepsin-like proteins. Human cathepsins are best known from the ubiquitously expressed lysosomal cathepsins B, H, and L, and dipeptidyl peptidase I (DPP I), which until recently were considered to mediate primarily “housekeeping” functions in the cell. However, mutations in DPP I have now been shown to underlie Papillon-Lefèvre syndrome and pre-pubertal periodontitis. Other cathepsins are involved in tissue-specific functions such as bone remodeling, but relatively little is known about the functions of several recently discovered enzymes. Collectively, CPs participate in multiple host systems that are active in health and in disease. They are involved in tissue remodeling and turnover of the extracellular matrix, immune system function, and modulation and alteration of cell function. Intracellularly, CPs function in diverse processes including normal protein turnover, antigen and proprotein processing, and apoptosis. Extracellularly, they can contribute directly to the degradation of foreign proteins and the extracellular matrix. However, CPs can also participate in proteolytic cascades that amplify the degradative capacity, potentially leading to pathological damage, and facilitating the penetration of tissues by cancer cells. We know relatively little regarding the role of human CPs in the oral cavity in health or disease. Most studies to date have focused on the potential use of the lysosomal enzymes as markers for periodontal disease activity. Human saliva contains high levels of cystatins, which are potent CP inhibitors. Although these proteins are presumed to serve a protective function, their in vivo targets are unknown, and it remains to be discovered whether they serve to control any human CP activity.

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