scholarly journals DNA methylation changes associated with risk factors in tumors of the upper aerodigestive tract

Epigenetics ◽  
2012 ◽  
Vol 7 (3) ◽  
pp. 270-277 ◽  
Author(s):  
Samson Mani ◽  
Kasia Szymańska ◽  
Cyrille Cuenin ◽  
David Zaridze ◽  
Karen Balassiano ◽  
...  
Keyword(s):  
Risk Factors ◽  
Dna Methylation ◽  
Aerodigestive Tract ◽  
Upper Aerodigestive Tract

Risk factors for esophageal cancer and the multiple occurrence of carcinoma in the upper aerodigestive tract

Surgery ◽  
2002 ◽  
Vol 131 (1) ◽  
pp. S1-S6 ◽  
Author(s):  
Masaru Morita ◽  
Hiroshi Saeki ◽  
Masaki Mori ◽  
Hiroyuki Kuwano ◽  
Keizo Sugimachi
Keyword(s):  
Risk Factors ◽  
Esophageal Cancer ◽  
Aerodigestive Tract ◽  
Upper Aerodigestive Tract ◽  
Multiple Occurrence

scholarly journals Dietary risk factors for upper aerodigestive tract cancers

2002 ◽  
Vol 99 (2) ◽  
pp. 267-272 ◽  
Author(s):  
Christine M. Kasum ◽  
David R. Jacobs ◽  
Kristin Nicodemus ◽  
Aaron R. Folsom
Keyword(s):  
Risk Factors ◽  
Aerodigestive Tract ◽  
Upper Aerodigestive Tract ◽  
Dietary Risk Factors ◽  
Dietary Risk ◽  
Upper Aerodigestive Tract Cancers

Angioedema of the Upper Aerodigestive Tract: Risk Factors for Intubation and Review of Management Algorithm

2013 ◽  
Vol 149 (2_suppl) ◽  
pp. P46-P46
Author(s):  
Christopher Brook ◽  
Anand K. Devaiah ◽  
Elizabeth Mahoney
Keyword(s):  
Risk Factors ◽  
Aerodigestive Tract ◽  
Upper Aerodigestive Tract ◽  
Management Algorithm

scholarly journals Swallowing Outcomes in Elderly Patients following Microvascular Reconstruction of the Head and Neck

2018 ◽  
Vol 159 (2) ◽  
pp. 320-327 ◽  
Author(s):  
Mitchell L. Worley ◽  
Evan M. Graboyes ◽  
Julie Blair ◽  
Suhael Momin ◽  
Kent E. Armeson ◽  
...  
Keyword(s):  
Risk Factors ◽  
Elderly Patients ◽  
Academic Medical Center ◽  
Multivariable Analysis ◽  
Aerodigestive Tract ◽  
Microvascular Reconstruction ◽  
Upper Aerodigestive Tract ◽  
Swallowing Function ◽  
Swallowing Outcomes

Objective To describe swallowing outcomes in elderly patients undergoing microvascular reconstruction of the upper aerodigestive tract and identify risk factors for poor postoperative swallowing function. Study Design Case series with chart review. Setting Academic medical center. Subjects and Methods Sixty-six patients aged ≥70 years underwent microvascular reconstruction of the upper aerodigestive tract. The primary outcome measure was the Functional Oral Intake Scale (FOIS); preoperative and postoperative scores were dichotomized to define “good swallowing” and “poor swallowing.” Logistic regression was performed to identify risk factors for poor postoperative swallowing function. Results In total, 91% of reconstructions were performed for oncologic defects. The most common defect site was the oral cavity (67%), and the anterolateral thigh (29%) was the most frequently used donor site. At 3-year follow up, 75% of patients had good swallowing function with 95% of patients who achieved good swallowing function doing so within 6 months of surgery. On multivariable analysis, patients with pT4 tumors (odds ratio [OR], 5.2; 95% confidence interval [CI], 1.0-25.6) and those undergoing at least partial glossectomy (OR, 4.7; 95% CI, 1.1-20.7) were more likely to experience poor swallowing function at 6-month follow-up. Conclusion Approximately half of elderly patients achieve good swallowing function within 6 months following microvascular reconstruction of the upper aerodigestive tract. Elderly patients with pT4 tumors and those requiring glossectomy are at highest risk for poor swallowing outcomes. These data can be used to inform preoperative patient counseling and design interventions aimed at improving swallowing function in those at high risk for poor outcomes.

Soft palatal melanosis as a predictor for neoplasia in the upper aerodigestive tract.

2017 ◽  
Vol 35 (15_suppl) ◽  
pp. 1542-1542
Author(s):  
Kenro Hirata ◽  
Akira Yokoyama ◽  
Rieko Nakamura ◽  
Tai Omori ◽  
Hirofumi Kawakubo ◽  
...  
Keyword(s):  
Risk Factors ◽  
High Risk ◽  
Aerodigestive Tract ◽  
Upper Aerodigestive Tract ◽  
Endoscopic Screening ◽  
Logistic Analysis ◽  
Individual Number ◽  
New Strategy ◽  
Alcohol Flushing ◽  
The Individual

1542 Background: Squamous cell dysplasia and carcinoma in the upper aerodigestive tract (UAT) was frequently accompanied by melanosis in the UAT. Soft palatal melanosis can be detected by visual inspection during routine physical examination or even personally in a mirror. Methods: We reviewed digitalized records of high-quality endoscopic images of the soft palate of 1786 Japanese alcoholic men who underwent endoscopic screening combined with esophageal iodine staining and evaluated to what extent the presence of soft palatal melanosis combined with other risk factors can predict the risk of UAT neoplasia. Results: Soft palatal melanosis was observed in 381 (21·3%) of the subjects (mild, 15·0%; distinct, 6·3%). An older age, an inactive heterozygous aldehyde dehydrogenase-2 genotype, smoking, and a high mean corpuscular volume (MCV) were positively associated with the presence of soft palatal melanosis. The age-adjusted odds ratio (OR [95% CI]) for neoplasia in the UAT was 1·92 [1·40–2·64] in the group with melanosis and 2·51 (1·55–4·06) in the group with distinct melanosis, compared with the melanosis-free group. A multiple logistic analysis including the alcohol and aldehyde dehydrogenases genotypes and non-genetic risk factors showed that the presence of soft palatal melanosis was independently associated with a high risk of neoplasia in the UAT. We calculated the individual number of risk factors out of four easily identifiable and significant factors: age ≥55 years, current/former alcohol flushing, MCV ≥106 fl, and distinct soft palatal melanosis. Compared with the risk-factor-free condition, the OR (95% CI) values of UAT neoplasia for one, two, three and four risk factors were 1·49 (0·97–2·30), 3·14 (2·02–4·88), 4·80 (2·71–8·51) and 7·80 (2·17–28·1), respectively. Conclusions: Soft palatal melanosis combined with other simple risk assessments provides a simple new strategy for identifying heavy drinkers with a high risk for UAT neoplasia.

scholarly journals Upper Aerodigestive Tract Squamous Cell Carcinomas Show Distinct Overall DNA Methylation Profiles and Different Molecular Mechanisms behind WNT Signaling Disruption

Cancers ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 3014
Author(s):  
Sheila Coelho Soares-Lima ◽  
Hisham Mehanna ◽  
Diego Camuzi ◽  
Paulo Thiago de Souza-Santos ◽  
Tatiana de Almeida Simão ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Wnt Signaling ◽  
Signaling Pathways ◽  
Squamous Cell ◽  
Molecular Mechanisms ◽  
Genetic Alterations ◽  
Squamous Cell Carcinomas ◽  
Aerodigestive Tract ◽  
Upper Aerodigestive Tract ◽  
Genome Wide

Upper aerodigestive tract (UADT) tumors present different biological behavior and prognosis, suggesting specific molecular mechanisms underlying their development. However, they are rarely considered as single entities (particularly head and neck subsites) and share the most common genetic alterations. Therefore, there is a need for a better understanding of the global DNA methylation differences among UADT tumors. We performed a genome-wide DNA methylation analysis of esophageal (ESCC), laryngeal (LSCC), oral (OSCC) and oropharyngeal (OPSCC) squamous cell carcinomas, and their non-tumor counterparts. The unsupervised analysis showed that non-tumor tissues present markedly distinct DNA methylation profiles, while tumors are highly heterogeneous. Hypomethylation was more frequent in LSCC and OPSCC, while ESCC and OSCC presented mostly hypermethylation, with the latter showing a CpG island overrepresentation. Differentially methylated regions affected genes in 127 signaling pathways, with only 3.1% of these being common among different tumor subsites, but with different genes affected. The WNT signaling pathway, known to be dysregulated in different epithelial tumors, is a frequent hit for DNA methylation and gene expression alterations in ESCC and OPSCC, but mostly for genetic alterations in LSCC and OSCC. UADT tumor subsites present differences in genome-wide methylation regarding their profile, intensity, genomic regions and signaling pathways affected.

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